3QBW,3QBX,3CQY,4MO5,4MO4


Conserved Protein Domain Family
ASKHA_NBD_ANMK
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cd24050: ASKHA_NBD_ANMK 
nucleotide-binding domain (NBD) of anhydro-N-acetylmuramic acid kinase (ANMK) and similar proteins
ANMK (EC 2.7.1.170), also called AnhMurNAc kinase, catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. It is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
Links
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Statistics
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PSSM-Id: 466900
Aligned: 59 rows
Threshold Bit Score: 428.105
Created: 21-Dec-2022
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is located in a cleft between domains I and II of N-terminal domain (NTD) of ANMK.
  • Structure:4MO5; Pseudomonas aeruginosa ANMK in complex with AMPPCP and anhMurNAc, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   #    #                                                                  
3QBW_A      4 YLGLMSGTSLDGMDIVLIeqg-----drTTLLASHYLPmpaGLREDILALcvpgpdEIARAAEVEQRWVALAAQGVRELL 78  Pseudomonas aerugi...
4MO5_B      4 YLGLMSGTSLDGMDIVLIeqg-----drTTLLASHYLPmpaGLREDILALcvpgpdEIARAAEVEQRWVALAAQGVRELL 78  Pseudomonas aerugi...
Q9F7Q9      6 YIGAMTGTSHDAIDISFLsig-----tkIHLEYFHSIKfpkSLRLKVKKLiennesSLSDLGTINKEIGFLFSKSINEAI 80  uncultured marine ...
Q31IS6      9 YIGLMSGTSLDGVDAALVsiq----ngeLELKAFQTFPytdNLKKQLHHLnqtphvDLKALCDMEYQVANAFSEATQQLL 84  Hydrogenovibrio cr...
ACR79589   16 VLGLMSGTSADGLDIALVkvsgktqdlrFSLEFFKSIPypkDLREKIIRAynpnvsTVKDITELNFALAREHVKMIKGLG 95  Kosmotoga olearia ...
CDE91822    9 VIALMSGTSCDSIDAGLCevyp---dmtVKLIQGINYKypeHIRAKIFQLfrg-eaSVKDICQMNFAIGKCFAEACKVLI 84  Fusobacterium sp. ...
KXK01609   11 VLGILSGTSADAVDIALIkikgg-eklqLNVEKFDSYPinkELKDYLLLCsskdkiQTDLICKLNFAVGNLFSDCILSFL 89  Chlorobi bacterium...
OLA09638    3 VIGLMSGTSLDGCDVALVeie----kdnYKLIDYLLYPysdEFKEKIKRNlsddtaKLSEICSLNFELPHVFKKAVDSLL 78  Coprobacillus sp. ...
RLC66307    3 VMGLMSGTSCDGCDVSIIeie----egrPKLLFFYSKEypeKLRKRIRRCmdrekgTVDLITQVNFEIGHFFGEVAKEAM 78  Chloroflexi bacterium
RYF26824   19 IIGLMSGTSMDGLDIALCkckgsgtdtaVELVNFVTIPyqdDFRADVKSIfskrdaDLEKVTLLNEKIGLIHAEMILEAL 98  Flavobacteriales b...

Feature 1                    #  #  #                                    #          ####       
3QBW_A     79 LqqqmspdevRAIGSHGQTIRHEPa--------rHFTVQIGnPALLAELTgIDVVADFRRRDVAAGgqgAPLVPAFHQAL 150 Pseudomonas aerugi...
4MO5_B     79 LqqqmspdevRAIGSHGQTIRHEPa--------rHFTVQIGnPALLAELTgIDVVADFRRRDVAAGgqgAPLVPAFHQAL 150 Pseudomonas aerugi...
Q9F7Q9     81 GfskikkssiECVAISGQTIRHEInk------rfPFSMQIGdPNIVAKETgLLVVSDFRNMHIALGgegAPLVPEFHNQL 154 uncultured marine ...
Q31IS6     85 DncdhvasdiRAIGSHGQTIFHAPd--------iPMSLQIGhPAFIAKNTgITTVADFRIDDMANNgqgAPLAPAFHQKL 156 Hydrogenovibrio cr...
ACR79589   96 Lq-------fDLIGYHGQTVYHMPe--------aGATLQLGeADVLAVELgVPVVHSFRTKDMALGgqgAPIVSYFDWVV 160 Kosmotoga olearia ...
CDE91822   85 Sefg----kpDFISSHGQTIYHYPfdkkidginlKSTLQIGeSSVIAQETnCLTISNFREADMAQGgqgAPLVCFADEKW 160 Fusobacterium sp. ...
KXK01609   90 HnynidasdiYCIGSHGQTIHHIPtienflnyngRSTLQIGePCLIAKKTgIDTVADFRTADIAIGghgAPLVPYLDYIL 169 Chlorobi bacterium...
OLA09638   79 EknnlsykdiELIASHGQTIWHCPhggk---nqvPSTLQIGsGQVLSTLTqVKVVSNFRLSDVALGgegAPLVPEFEYLY 155 Coprobacillus sp. ...
RLC66307   79 Vksg---itpHLIASHGQTIYHIPrpdqnkgektKSTFQIGeAACIVEKTgIPVISDFRVQDVAAGgdgAPLVPMADFIM 155 Chloroflexi bacterium
RYF26824   99 QqwnvepnevDVIASHGQTIFHAPkslhgkadypNATLQIGdGDHIAVKTgVITLADFRQKHLAAGgegAPLAVYGDYLV 178 Flavobacteriales b...

Feature 1                  ##                        #   #           ####                     
3QBW_A    151 FgdddTSRAVLNIGGFSNVSLLSpg---kpVRGFDCGPGNVLMDAWIHHQrg-eHFDRDGAWAASGqvnHALLASLLADE 226 Pseudomonas aerugi...
4MO5_B    151 FgdddTSRAVLNIGGFSNVSLLSpg---kpVRGFDCGPGNVLMDAWIHHQrg-eHFDRDGAWAASGqvnHALLASLLADE 226 Pseudomonas aerugi...
Q9F7Q9    155 FykarNPRIILNIGGISNYSFVKnr---ndIWGTDVGPGNAILDAYCSDFlq-iPFDKNGAIAAKGkvdHIELGRLLQNN 230 uncultured marine ...
Q31IS6    157 Fgn-tVGTAVVNIGGISNITFLDqq----kTLGFDTGPGNGLMDEYCEQFfn-cSYDADGKMAQTGqvnMALLSDLMQEP 230 Hydrogenovibrio cr...
ACR79589  161 Fgr-eSGTATLNIGGIANLTYLSkkr--enVIAFDTGPGNCLIDVVVNKYys-qPFDIDGKIAKKGkirDDVIELLMMKD 236 Kosmotoga olearia ...
CDE91822  161 FknkgKNFAIQNIGGISNVTVVSkd---fdTFGFDTGLGNIMIDYCMNKYfs-lPYDKDGEIAKEGtisDSWLACLLQDE 236 Fusobacterium sp. ...
KXK01609  170 Fks-eNPRVLLNIGGIANLTYLKkdcevedVIAFDCGPGNMIIDSVSEALfn-lEFDQNGEIASKGkvsEILFEYIKSLD 247 Chlorobi bacterium...
OLA09638  156 FkddqKNVVLQNIGGMGNLTYIPkkaseddIIAFDTGPGNVMIDHFMKKYyn-kDYDENGEIALKGsiiLPIFNELIKDS 234 Coprobacillus sp. ...
RLC66307  156 FrdknKSISIHNIGGISNLTYIPkganpedVIAFDTGPGNVLINQLTRELfn-mEYDSEGKIAKEGkihMEIVNKLLEHP 234 Chloroflexi bacterium
RYF26824  179 FskadESRIMLNIGGIANFTYLPgdldaskVFSTDVGPGNTLMDQFIQQQrpgrYYDENASMAKSGtlnSALLSELLNDE 258 Flavobacteriales b...

Feature 1                                                                            ##  ##   
3QBW_A    227 FFaa--rgPKSTGRERFNLPWLQEHLarhp--alpAADIQATLLELSARSISESLLDAqp---dcEEVLVCGGGAFNTAL 299 Pseudomonas aerugi...
4MO5_B    227 FFaa--rgPKSTGRERFNLPWLQEHLarhp--alpAADIQATLLELSARSISESLLDAqp---dcEEVLVCGGGAFNTAL 299 Pseudomonas aerugi...
Q9F7Q9    231 FFkr--kcPKSTGKELFNIKILSKKFlk-----kkAEDILCTLVEFSAKSIINSIHKNgh---nnCDIVICGGGAHNKYL 300 uncultured marine ...
Q31IS6    231 YFrl--paPKTTGKDLFNSDWLNPFLakys--nvsKKDILSTLNQLTVDTIIQGLNTLps---qpKRLLICGGGAENKTL 303 Hydrogenovibrio cr...
ACR79589  237 ADyiekspPKTTGRERYNEEFLDGIKc-------pPKDLVRTLTRFTALSIHLNIKKHvp---ktKKLIVTGGGAFNPVL 306 Kosmotoga olearia ...
CDE91822  237 YYfm--npPKSTGREYFSPKYIENTLkfa---pqnPKDIIATVTALTAKTIADSYERFiypnvgiHEAVICGGGAYNKTL 311 Fusobacterium sp. ...
KXK01609  248 DFinq-ppPKSTGRELYGKEFVEQILnfsydnnitPVDIIATVSEYTVYGITNGVSYVlkd-tneFEFLISGGGANNNYL 325 Chlorobi bacterium...
OLA09638  235 FFeq--mpPKSTGREKYSFEALELLAdkysfdmyaKEDIITTITEITVYSISLNYRKFlk---giDKIVISGGGVHNQYI 309 Coprobacillus sp. ...
RLC66307  235 YFnl--npPKSTGPEEFNIDLLREYIhr-----vpGKDLLASVTFFTAKSIAMAYKRYvip-lglDEILVAGGGAYNRTL 306 Chloroflexi bacterium
RYF26824  259 FFki--dfPKTTGPELFNLAYLQHAQqrsgtvnlaPEDVMATLCHFSANGIIDAIKRTvns-salPKILMSGGGMHNPLL 335 Flavobacteriales b...

Feature 1                                 #                                    
3QBW_A    300 MKRLAMLMp-eARVASTDEYGIpp-awMEGMAFAWLAHRFLErlpgNCPDVTGALGPrTLGALYP 362 Pseudomonas aeruginosa
4MO5_B    300 MKRLAMLMp-eARVASTDEYGIpp-awMEGMAFAWLAHRFLErlpgNCPDVTGALGPrTLGALYP 362 Pseudomonas aeruginosa
Q9F7Q9    301 VKRISEMAs--NDIVLSSDLGHdv-faIESMAFAWMGYKRVSnealIVQTSSKNVKG-LLGSITK 361 uncultured marine gamma proteobac...
Q31IS6    304 ISRLQAQLs--YPVKTTQSVGVpp-haIEAMMCAWLAEQRLNntpiALQHITGATKDsVLGAVWH 365 Hydrogenovibrio crunogenus XCL-2
ACR79589  307 TDDIRSFG---YEVEIPDKTFVe---aKEAIAIAVLANEFLNgvttNIPNVTGAEREaTLGKLSL 365 Kosmotoga olearia TBF 19.5.1
CDE91822  312 MKYLRTYLpsyIDLKTCEDYGIsn-nfKEVMAFALLGYCTYYgipnNLPCCTGAKKRvVMGKLTY 375 Fusobacterium sp. CAG:815
KXK01609  326 IDRLGKEFs--DAKFVCDFPGNvtaenKEAVLFGLLAYQTLKgvknNIPSATGAIKKtILGKICP 388 Chlorobi bacterium OLB4
OLA09638  310 IKRLKEEFp--GIVYSLDECGLns-daKEAFAFAVLGYLTLNgkhgNVTKATGARKKvVLGELSY 371 Coprobacillus sp. 28_7
RLC66307  307 IEWLKAELk-gIPVYTFEEKGVns-kaRESMAFAILGYLAWNkkpnNLPQVTGARHPvIMGKISF 369 Chloroflexi bacterium
RYF26824  336 VSLLKQALp-dATFSTTDELAInp-daKEAVLFALLANETLAgnpiNFGDREGVPSV-CMGKISL 397 Flavobacteriales bacterium

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