Conserved Protein Domain Family
Mei5

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pfam10376: Mei5 
Double-strand recombination repair protein
Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologs, Rad51 and Dmc1. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

pfam10376 is classified as a model that may span more than one domain.
pfam10376 is the only member of the superfamily cl28769
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006630886  13 FCTPD--S----------TLNSTPHGLSVKQPMSASLKERLKRTRRSFHSPFTVAKRLKIDppEAEDDSKVQEVSPKSER 80 
XP_008268702  50 PSTPQacA----------NPPSSLARSSGKQPMSATLRERLRKTRVSFNSCYSVVKRLKVD--NEENDQNLSEKPPSATE 117
XP_004749372  12 PSTPRacA----------SPPSPRTSSLRKQPMSATLRERLRKTRSSFNSHYNVVKRLKVE--NEENDQTFPEKPASSTE 79 
Q86XK3        25 PSTPQasA----------NPSSPYTNSSRKQPMSATLRERLRKTRFSFNSSYNVVKRLKVE--SEENDQTFSEKPASSTE 92  human
XP_010587307  11 PSTPQacE----------IPSSPCTYSSGKQPMSATLRERLRKTRSSFNSCSSVVKRLKVE--NEESDPIFSEKPVSSME 78 
XP_007479134  12 PATPKasE----------TVAVSQSHSSGKQLMSATLRERLKKTRSSFNSCYALAKRVKGD--TEENNSTVSKRATSSSD 79 
XP_003218562  13 CSTPEtsD----------QKSCS---SSEKQPMSSTLRERLKKARRSFHSTLIVPKRLKID--EENNCSSTCKEESLPKG 77 
Q9USV1        71 ALTPDlrDtkihtslpitTPFSKKRAREAKNILLKPFKSPLRQTASPQVADTNLKPSLAVTnlNSDETNTSSEPVTSPLR 150 Schizosaccharom...
P32489        15 VNEEEntC----------INHSYTKKDTNNYRVGKSGIKDLKKPTNQ--------KEIAIK-----NRELTKQLTLLRQE 71  Saccharomyces c...
EDO15526      21 VNDPDkrP----------LLT-----DLGKSSINKG-FNKVNANDSS--------KELRIL-----NNELSKELAEVSKK 71 
XP_006630886  81 DLDSaGGNTVSINKGRPWESPEV---TDTSRQWDVCRTGTEsgneaaqssSSRERADPPAQI------------DLLQLR 145
XP_008268702 118 ENCLeFQESFKRIDSELEESTHL---KNTFQNVSACEATSLdtg----scSVLQNDFMKENLpi---------qGLKEER 181
XP_004749372  80 ENCLeLQENFKHKDGEFKESTYL---KNTFKNISACESKSLdte----scSDLQSDFVNEELpk---------qGLSEER 143
Q86XK3        93 ENCLeFQESFKHIDSEFEENTNL---KNTLKNLNVCESQSLdsg----scSALQNEFVSEKLpk---------qRLNAEK 156 human
XP_010587307  79 ENHLeFQGSFKHTDSESEKSTYL---KNTFKNISACESKSLdtg----scSALQNDFASENLpk---------qELKEEK 142
XP_007479134  80 GSCSgSSENCKNMEKA-EESLCL---KDPLKDVDVYRSE------------SLELSGLPDNLpvvseghsigkkELLEEK 143
XP_003218562  78 ESYCiSQSKDEDLEKVPDETSHL---KSTIQERDLCMSECTgysknaqgsTEVLLLGKDDRLw-----------ELMEEK 143
Q9USV1       151 TT----PNSIK------RQKRLF---KSPISNCLNPKSDpe-------------------------------itQLLSRR 186 Schizosaccharom...
P32489        72 NNHL--QQACKILS----ENKIIenrKSIEKWRTICEME-----------LSFILNSTLIKInrmggykdflekEMEAKK 134 Saccharomyces c...
EDO15526      72 IDQL--KQSIKILNRYEEQDKNL---KLIEKWRGVSKAG-----------MSYIFNSLRFRIdkmggyeefrrkEIEAEK 135
XP_006630886 146 DRLKKEVGE----------KEEMLRRLKMVRMYRTKNDLDKLQFLINKWRGSSQAVLYELKSAFC--------------- 200
XP_008268702 182 AKLVKQVQE----------KEDLLRRLKLVKMYRSKNDLSQLQSLIKKWRNCSQLLLHELHSAMS--------------- 236
XP_004749372 144 TKLMKQIEE----------KEDLLRRLKLVKMYRSKNDLSQLQLLIQKWRSCSQLLLYELQSAMS--------------- 198
Q86XK3       157 AKLVKQVQE----------KEDLLRRLKLVKMYRSKNDLSQLQLLIKKWRSCSQLLLYELQSAVS--------------- 211 human
XP_010587307 143 AKLVKQVQE----------KEDFLRRLKLVKMYRSKNDLSQLQLLIKKWRNCSQQLLYELQSAMS--------------- 197
XP_007479134 144 MKLLKQVQE----------KEELLRRLKLTKMYRSKNDLSHLQSLIKKWRNSSQLLLFELQSTLS--------------- 198
XP_003218562 144 ATLVKQVQE----------KEELLRRLKLVKMYRSKNNPTELQSLISKWRSSSQMMLYELQMALA--------------- 198
Q9USV1       187 LKLEKEVRN----------LQEQLITAETARKVEAKNEDKDLQTLIQKWKNAAQQAAEVLFKPMAerirlaggvtqsfri 256 Schizosaccharom...
P32489       135 RRLEYQIDNgmedqiceikESDDFRQLSEVEKQEWESQMNE---QLKELEKKKIAELEKLNKVLH--------------- 196 Saccharomyces c...
EDO15526     136 RKIEYQFDDglqneidnilDSEEFKALPIDDQIEYKEKMDE---KIQQAEEYKLKQFEKFDKELA--------------- 197
XP_006630886 201 -T-DGR--------QLSLTQLIDHYGLDDRILHYN 225
XP_008268702 237 -E-ENK--------KLSLTQLVDHYGLDDKLIHYN 261
XP_004749372 199 -A-ENR--------KLSLTQLIDHYGLDDKLLHYN 223
Q86XK3       212 -E-ENK--------KLSLTQLIDHYGLDDKLLHYN 236 human
XP_010587307 198 -E-ENK--------KLSLTELIDYYGLDDKLLHYN 222
XP_007479134 199 -V-ENK--------KLSLTQLIDSYGLEDQLLHYN 223
XP_003218562 199 -T-DNQ--------KLSITQLIDNFGLDDQLLHYN 223
Q9USV1       257 eEgENKgqiqevrtEFTMSMFLNQFGVPVHLMSFD 291 Schizosaccharomyces pombe 972h-
P32489       197 -DsEGK--------DFGMAELCTRLKLDYSLIFPQ 222 Saccharomyces cerevisiae S288C
EDO15526     198 -NaSNK--------ELTMEELADRLKVEYKLIFSS 223
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