1MRO


Conserved Protein Domain Family
MCR_gamma

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pfam02240: MCR_gamma 
Methyl-coenzyme M reductase gamma subunit
Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (pfam02249), 2 beta (pfam02241), and 2 gamma (this family) subunits with two identical nickel porphinoid active sites.
Statistics
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PSSM-Id: 396698
Aligned: 19 rows
Threshold Bit Score: 452.189
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1MRO_C           1 AQYYPGTTKVAQNRRNFCNPEYELEKLREISDEDVVKILGHRAPGEEYPSVHPPLEEMDEPEDAIREMVEPIDGAKAGDR 80 
jgi:Mpal_2308    5 PQYGPGTSVVAENRRKYMDPGHKLEKVRDITDEDIVLIMGHRAPGSAYPTAHPPLAEQQEPNCPVRKLVTPTEGAKAGDR 84 
WP_015284893     6 PQYGPGTSVVAANRRKQMDPGQVLTKMRSITDEDIVLLLGHRAPGERFRNVHPPVTEQTEPACPMRKLVRPTEGAKNGDR 85  Methanoregula...
WP_013329919     4 PQYGPGTSVVAQNRRNQMNPEYELSKIRSVTDEDIILILGHRAPGQAYPSAHPPLAEQQEPDDPMRKLVKPTEGAKAGDR 83  Methanolacini...
Q2FSN1           5 PQYGPGQSIVAENRRKQMNPNVKLEKIRNVTDEDIVLILGHRAPGQAYPTAHPPLAEQGEPDCPIRKIVTPTDGAKAGDR 84  Methanospiril...
Q0W340           5 PQFYPGKTSVAQNRKKFMDPSYKMEKLRSLSDDDIVIMLGHRAPGSAYKTIHPPLTESNEPDCPIRKLVEPTPGAKAGDR 84  uncultured me...
jgi:Mzhil_0856   5 PQFYPGNTIVAENRRKHM--SGKLEKLREISDEDLTLILGHRAPGSDYPSTHPPLAEMGEPECSIRELVEPTEGAKAGDR 82 
Q49173           5 PQFNPGETKIAENRRKHMNPNYELKKLREIADEDIVRVLGHRSPGESFKTVHPPLEEMDFEEDPMKDIVEPIEGAKQGTR 84  Methanothermu...
P21112           5 AQYTPGETQIAENRRKHMDPDYEFRKLREVSDEDLVKVLGHRNPGESYKSVHPPLDEMDFEEDIVRDMVEPIQGAKEGVR 84  Methanothermo...
Q2NHZ9           5 vQYYPGESVIAENRKKHMNPDHELKKLRNIADDDIVKLLSHRNPGEGYKTVHPPLDEMDFEEDTMKDFVEPIDGAKKGIR 84  Methanosphaer...
1MRO_C          81 VRYIQFTDSMYFAPAQPYVRSRAYLCRYRGADAGTLSGRQIIETRERDLEKISKELLETEFFDPARSGVRGKSVHGHSLR 160
jgi:Mpal_2308   85 VRYIQFADSMFNAPSQPYERTYLEMYRFRAIDPGTLSGRQIVECRERDLEKYAKELLNTELFDPARVGVRGATVHGHSLR 164
WP_015284893    86 VRYVQFADSMFNAPCQPYQRTYAEMYRFRGIDPGTLSGRQIVECRERDLEQYCRLLIETEMFDPALVSLRGATVHGHSLR 165 Methanoregula...
WP_013329919    84 VRYIQFADSMFNAPCQPYQRTYMEMYRFRAIDPGTLSGRQIVECRERDLEQYSKILIETEVFDPATVSCRGATVHGHSLR 163 Methanolacini...
Q2FSN1          85 VRYIQFADSMFNAPSQPYQRTYTECYRYRGIDPGTLSGRQIVECRERDLEKISADLINTNLFDPARVGIRGATVHGHSLR 164 Methanospiril...
Q0W340          85 IRYNQYADSMYFAPMVPYLRSWMAVTRYRGVDPGTLSGRQIIEARERDLEKITKETFETEMFDPARTSLRGCTVHGHSLR 164 uncultured me...
jgi:Mzhil_0856  83 VRYVQFVDSMYNAPATPYFRSYFAAINFRGVDPGTLSGRQVVEARERDMENVAKVSLETEISCPALSGLRGATVHGHSLR 162
Q49173          85 IRYIQFADSMYNAPAQPYDRARTYMWRFRGVDTGTLSGRQVIEMRELDLEKVSKILLETEIFDPARCGIRGATVHGHSLR 164 Methanothermu...
P21112          85 VRYIQFADSMYNAPAQPYDRARTYMWRYRGVDTGTLSGRQVIEMRELDLEGVSKELVETELFDPATTGIRGATVHGHSLR 164 Methanothermo...
Q2NHZ9          85 IRYIQFADSMYNAPAQPYDRARSYMRRFRGVDTGTLSGRQVIEMRESDLEETSKLLLESEFFDSAKTGLRGATVHGHSLR 164 Methanosphaer...
1MRO_C         161 LDEDGMMFDMLRRQIYNKDTGRVEMVKNQIGDELDEPVDLGEPLDEETLMEKTTIYR-VDGEAYRDDVEAVEIMQRIHVL 239
jgi:Mpal_2308  165 LDEDGMMFDMLQRCVFDKKDGIVKYVKNQIGEPLDRAVPVGKPMDEKWLKAHSTIFHsLDGVAFRDDPEYVEYIQRIHSL 244
WP_015284893   166 LAEDGMQFDALQRCVLG-TDGMVRYVKDQIGLPLNRPVEVGKPLGQPWLKEHSTIFHcLVGTALRDDAEYVEYLKRIHTL 244 Methanoregula...
WP_013329919   164 LAEDGLMFDALQRCILA-EDGNVCYVKDQIGIPLDRPVYVGKPMDEEWLREKSTIFHsLVGTALRDDKEYVKYIQRIHSL 242 Methanolacini...
Q2FSN1         165 LAEDGMMFDMLQRCIL--EGGTVKYVKDQIGTPLDKKVDVGKPMDDAWLKANTTMFHsLVGTPYRSDAEYIEYIQRIHSL 242 Methanospiril...
Q0W340         165 LNENGMMFDMLQRQVLD-KDGTVKAVKDQVGDPLDRKVNLGKPMSEAELKKRTTIYR-IDGVSFRSDDEVVGWVQRIFTL 242 uncultured me...
jgi:Mzhil_0856 163 LQEDGVMFDMLDRRRL--ENGTIIMDKDQVGRPLDKKVDLGKPMSEDEAAKRTTIFR-ADNVAFRDDEEVVEWVHRVWSQ 239
Q49173         165 FDENGLMFDALQRYIYDEDSGHVVYVKDQVGRPLDQPVDMGEPLPEDELKEITTIYR-KDNIGMREDEELLEVVNKIHEA 243 Methanothermu...
P21112         165 LDENGLMFDALQRYVFDEEKGHVVYVKDQVGRPLDEPVDMGQPLGEDELKKITTIYR-KDNIAMRDDKEAIEVVENIHTG 243 Methanothermo...
Q2NHZ9         165 LDEDGLMFDALQRYVFDKETGHVVYVKDQVGVELDEPIDVGEPLPEDELKKITTIYR-SDNVSLRDDEEVIKVVEAIHFA 243 Methanosphaer...
1MRO_C         240 RSQGGFN 246
jgi:Mpal_2308  245 RTKYGFM 251
WP_015284893   245 RTRYGFM 251 Methanoregula formicica
WP_013329919   243 RTKYGFM 249 Methanolacinia petrolearia
Q2FSN1         243 RTKYGFM 249 Methanospirillum hungatei JF-1
Q0W340         243 RTKCGFY 249 uncultured methanogenic archaeon
jgi:Mzhil_0856 240 RTKYGFQ 246
Q49173         244 RTIGGFG 250 Methanothermus fervidus DSM 2088
P21112         244 RTMGGFG 250 Methanothermobacter thermautotrophicus str. Delta H
Q2NHZ9         244 RTDGGYG 250 Methanosphaera stadtmanae DSM 3091
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