4EUK,3MM4,2R25,2AYX,5KBX,1DCF,4XLT,3M6M,3I42,3GRC


Conserved Protein Domain Family
REC_hyHK_CKI1_RcsC-like

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cd17546: REC_hyHK_CKI1_RcsC-like 
Click on image for an interactive view with Cn3D
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC
This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.
Statistics
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PSSM-Id: 381099
Aligned: 198 rows
Threshold Bit Score: 70.1909
Created: 9-Nov-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:[ED] [ED] [ED]Click to see conserved feature residue pattern help
Evidence:
  • Structure:4EUK: Arabidopsis thaliana AHK5 REC domain binds Mg2+
  • Comment:also based on metal binding site of other family members
  • Comment:signal transduction in two-component systems is mediated by metal ion dependent phosphorelay reactions between protein histidine kinases and phosphoaccepting receiver domains in response regulator proteins
  • Comment:for many receivers, Mg2+ is the preferred metal ion, but other divalent ions such as Mn2+ are also used

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ##                                                              #           
4EUK_A         11 ILLVEDNkINIMVAKSMMKQLGh--------TMDIANNGVEAITAins------------ssYDLVLMDVCMpvldgLKA 70   thale cress
EJY66801      518 ILVVDDNhFNIIAMNLMLEEAFkimkiekapEIDSAVDGLDGLEKmalkski----nccnmpYKLVLIDLNMpnmggLQM 593  Oxytricha tri...
CAK74206      680 ILIVDDEqINILALSILLEQLGl--------NTDQVFNGKECVDLiyskqkktycgkcsdrqYQLIFMDINMplmdgWEA 751  Paramecium te...
EJY73310      896 IMIVDDSmFNLIPLELMLQNINn-------lQVIKAYNGLEAVNLykerlqk----tccnnkFKLIFMDLNMpimdgYQA 964  Oxytricha tri...
EJY73329     1193 ILIVDDSmFNLITLELILSQMFq-------vKCDKAFNGLEAVNLyqknlem----dccdkkYKLVLMDLNMpimdgYES 1261 Oxytricha tri...
Q9M8Y4         24 VLIVDDDpLNRRLHEMIIKTIGg--------ISQTAKNGEEAVILhrdg----------easFDLILMDKEMperdgVST 85   thale cress
F4JZT3         20 ALVVDDSfVNQTIHQKLLNRLGi--------KNDVVTNGKEAVDVycs-----------ggnYDLILMDMDMpimngIQA 80   thale cress
Q7XN30         12 ALLVEDIkVNRMILSQMLRKFQv--------ETTVVQNGKEAVELflg-----------getFDIVLTDNLMpimtgPEA 72   Japanese rice
XP_014627219   31 ALIVDDDaIIRKIHKTMLERLFn-------iEAKTVRDGKEAVDLcrs-----------genFDIIFMDKEMpimdgHEA 92   soybean
WP_015132476   12 VLIVEDDhINRAVFSKQMEQMQy--------DVASVKNGKEAAEYcsn------------ncVDIILMDCAMpvmngYEA 71   Leptolyngbya ...
Feature 1                                                                                        
4EUK_A         71 TRLIRSyeetgnwnaaieagvdistseneqvcmrptnRLPIIAMTANtlaess-eecyanGMDSFISKPVTLQKLRECL 148  thale cress
EJY66801      594 MKNIRAklddgg-------------------lmskykDTIFVLCTAQnennty--pykeaGFDYFLEKPIDLKVLESIL 651  Oxytricha trif...
CAK74206      752 SRQIKKw-----------------------------fSIAIIACTAFtdnetk-eqcyqnGLDYYLSKPVKRESLIQVL 800  Paramecium tet...
EJY73310      965 TQNIIQlfnekyqk----------------gsynngdQLNIVAITAFvneeni-nhcyavGMKEVLHKPVDQDSLKEVI 1026 Oxytricha trif...
EJY73329     1262 TKQIFElfkkkysa----------------kkypngdALTIVAITAFvndeni-nncykvGMEEVMNKPVNQDKLLSVL 1323 Oxytricha trif...
Q9M8Y4         86 TKKLREmk----------------------------vTSMIVGVTSVadqeeerkafmeaGLNHCLEKPLTKAKIFPLI 136  thale cress
F4JZT3         81 TKRLREmg----------------------------iESKIAGVTTRanegek-kefmeaGLNDFQEKPLTISKLLSIL 130  thale cress
Q7XN30         73 ISKIRAmg---------------------------atDVMIVGVSVDansme---efkdaGADLCVPKLKLEILEHILQ 121  Japanese rice
XP_014627219   93 TKHLRAmg----------------------------vKSIIVGITTRadgkdk-eeflasGSNHCFEKPLDQAKVEKVL 142  soybean
WP_015132476   72 ATKIRQeqye------------------------qshSPVIIGITAYampgdr-qkclaaGMDDYLAKPVYIKDLKTML 125  Leptolyngbya s...

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