Conserved Protein Domain Family
bHLH_TS_musculin
?
cd19703: bHLH_TS_musculin 
basic helix-loop-helix (bHLH) domain found in musculin and similar proteins
Musculin, also termed activated B-cell factor 1 (ABF-1), or Class A basic helix-loop-helix protein 22 (bHLHa22), is a bHLH transcription factor expressed in activated B lymphocytes. It acts as a transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. Musculin may play a role in regulating antigen-dependent B-cell differentiation. The mouse homolog, musculin, is suggested to be a repressor of myogenesis that is expressed in developing muscle and in the spleen. Musculin heterodimerizes with products of the E2A gene.
Links
?
Statistics
?
PSSM-Id: 381546
Aligned: 5 rows
Threshold Bit Score: 119.866
Created: 3-Aug-2018
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1            #   # ### #    #                 ####                         
O60682       105 KQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYEN 170 human
XP_418293    100 KQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYEN 165
POI22064      98 KQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYEN 163 Chinese bamboo-partridge
XP_021419942  81 RQMQRNVANARERARMRVLSKAFSRLKTSLPWVPADTKLSKLDTLRLASSYISHLRQLLQENHFES 146 rainbow trout
XP_018417834  78 KQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYDN 143 Nanorana parkeri

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap