Conserved Protein Domain Family
GPS2_interact
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pfam15784: GPS2_interact 
G-protein pathway suppressor 2-interacting domain
GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.
Links
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Statistics
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PSSM-Id: 464868
Aligned: 9 rows
Threshold Bit Score: 109.178
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_015793204   11 YYPGVEAISPALPS-EESQPdysstfrTSKDELLQNIDKIDREISQTETQISELKERKKQLELKAVSRdsvKDVRENVDN 89  
EKC21189      241 YNPQVEAISPTLPP-DETSP-------SSKDQLLQAISKVDREISKVDKDIQKLKKKQEQLELEKCKP---PEEKQKVKD 309 
EFN66084      133 YTPQTEAISPTLPE-PNTQEda---lrSTKDELLQQIGKVDREIAKRENQLNMLRKRIKELEEAANKPleaTGLKRNIEE 208 
XP_028032656  156 TYNTVEVLSPNPPSeTSGEDqt---lrTTKDVLLKQISKVDREMALVETSLAKLKRKQEELQQSASKP---ARAEEPEEA 229 
XP_027988036  149 FGGKHEAPSSPISGqPCGDDqnaspskLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKP---PEPEKPVSP 225 
PNJ81989       62 LTGKLEPVSPPSPP-HTDPElelvpprLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKP---PEPEKPVSP 137 
PNJ81989       62 LTGKLEPVSPPSPP-HTDPElelvpprLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKP---PEPEKPVSP 137 
NP_001007033  140 SIGKIEPISPVSPV-PMEADldlvpsrLSKEELIQNMDRVDREITMVEQQISKLRKKQQQLEEEAAKP---QEPERTISP 215 
XP_014287577  191 YNPQVEAISPTLPS-EA--LqedanfrSTKDDLLHGIAKVDREITKTELQISKLKRKQQELEEAAKKPaikKEEEEVPQP 267  brown marmora...

XP_015793204   90 S--SETRQLSIAQH 101 
EKC21189      310 IvvTETKHQSIAQI 323 
EFN66084      209 Qs-QQPKHQSLAQK 221 
XP_028032656  230 P----SRHRSLAQC 239 
XP_027988036  226 Pp-VEQKHRSIVQI 238 
PNJ81989      138 Pp-IESKHRSLVQI 150 
PNJ81989      138 Pp-IESKHRSLVQI 150 
NP_001007033  216 Pp-SEAKHRSLVQI 228 
XP_014287577  268 K------HQSPAQK 275  brown marmorated stink bug
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