1EY2


Conserved Protein Domain Family
hmgA

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TIGR01015: hmgA 
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homogentisate 1,2-dioxygenase
Missing in human disease alkaptonuria. [Energy metabolism, Amino acids and amines]
Statistics
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PSSM-Id: 273395
Aligned: 8 rows
Threshold Bit Score: 799.737
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1EY2_A        30 LKYISGFGNECSS--EdpRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSWLYRILPSVSHKpFESIDe--G 105 human
CAB50930      12 LAYLSGFGNEHAS--E--AVAGALPEGRNSPQRAPLGLYAEQLSGTAFTEPRAHNRRSWLYRIRPSAAHP-AFTRSgngT 86  Streptomyces co...
Q9X4F5        19 AGYMPGFGNDFET--E--SLPGALPQGQNSPQKCNYGLYAEQLSGSPFTAPRGTNERSWLYRIRPSVRHTgRFRRVdypH 94  Sinorhizobium m...
AAF36489       4 YKYLSGFGSHFSSedE--RYPNSLPVGQNSPQVCPYKLYAEQLSGSAFTAPRTENMRTWLYRKLPSAAHLpFQPFKg-aE 80  fruit fly
AAF61419       7 LKYLTGFGNEHATsdP--RVPDALPVGQNSPQKCSHGLYAEQLSGTAFTAPRSQNQRSWLYRIRPSVIHRpFEAMKendQ 84  Caenorhabditis ...
Q00667        12 YTYQNGFDSYHES--E--AIEGALPVGHNSPQKAPYGLYAEKLSGTAFTAPRHENKQTWVYRILPAAAHEnFVEEDassY 87  Aspergillus nid...
WP_010920389   3 LRYQTGFGSYFET--E--AHPGALPVGRNSPQKVPFGLYAEQLSGSAFTAPRHENRRTWLYRLRPSAGHEaYQPYAq--D 76  Caulobacter vib...
O09173         4 LKYISGFGNECASedP--RCPGSLPKGQNNPQVCPYNLYAEQLSGSAFTCPRNTNKRSWLYRILPSVSHKpFESIDq--G 79  house mouse
1EY2_A       106 HVTHNWDeVDP-DPNQLRWKPFEIPkaSqKKVDFVSGLHTLCGAGDIKSNNGLAIHIFLCNTSXeNRCFYNSDGDFLIVP 184 human
CAB50930      87 IRTAPFN-QAVpDPNRLRWNPLPVP--G-PATDFVEGLWTLGGNGDATQRTGMAVHLYHATASM-DRVFSDADGELLIVP 161 Streptomyces co...
Q9X4F5        95 WKTAPHVgEHSlALGQLRWSPLPAP--S-EALDFLQGIRTMTTAGDALTQAGMAAHAYAFNADMvDDYFFNADGELLIVP 171 Sinorhizobium m...
AAF36489      81 YFSQNWDeQPP-NPN--Q---------DgKNVNFVEGLHTVCGAGDPRSRHGLAIHIYSCNGSMdNSAFYNSDGDFLIVP 148 fruit fly
AAF61419      85 HWTNNFSsIPP-NPNQYRWNPFPLP--TkEGVTFVDNLYTVCGGGDVISRTGLAIHQFSCNASMeHTAMYNSDGDFLIVP 161 Caenorhabditis ...
Q00667        88 HTLSDAKkLQH-IPNQLRWDPFDLd----ETVDWVHGLHLVAGSGDPTVKQGLGILLYAAGKDMgKEAFYSADGDFLIVA 162 Aspergillus nid...
WP_010920389  77 KLVSAFPgPAT--PNRLRWSPLEIPa---APTDFVDGLVSLAGNADAATLGGIAAHVYLVNVSMkNRVFYNADGEMLIVP 151 Caulobacter vib...
O09173        80 HVTHNWDeVGP-DPNQLRWKPFEIPkaSeKKVDFVSGLYTLCGAGDIKSNNGLAVHIFLCNSSMeNRCFYNSDGDFLIVP 158 house mouse
1EY2_A       185 QKGNLLIYTEFGKXLVQPNEICVIQRGXRFSIDVF-EE--TRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYE 261 human
CAB50930     162 ERGGLLLRTEFGLLHAEPGHVALIPRGVRFRVQLLdED--ARGYVCENYGAPFQLPDLGPIGANGLANARDFRAPVAAYE 239 Streptomyces co...
Q9X4F5       172 ETGAIQVFTELGRMDVEPSEICLIPRGMMFKVTRLgEEkvWRGYICENYGAKFTLPDRGPIGANCLANPRDFKTPVAAYE 251 Sinorhizobium m...
AAF36489     149 QQGVLDITTEFGRMSVAPNEICVIPQGIRFAVNVD-SP--SRGYILEVYDDHFVLPDLGPIGANGLANPRDFETPVAWFD 225 fruit fly
AAF61419     162 QQGALEITTEFGRLLVNPQEIAVIPQGIRFSVAVR-GP--SRGYILEVYGTHFQLPDLGPIGANGLANPRDFEAPVAWFE 238 Caenorhabditis ...
Q00667       163 QHGVLDIQTELGRLLVRPNEICVIPRGVRYRVTLPdGP--VRGYICELYQGHYQLPELGPIGSNGLANARDFQAPVAAFD 240 Aspergillus nid...
WP_010920389 152 QMGELTLVTEMGVLKAGPGHIAVIPRGVRFRVEVE-GP--ARGYVCENYGAAFRLPELGPIGANGLANPRDFEAPVAAFE 228 Caulobacter vib...
O09173       159 QKGKLLIYTEFGKMSLQPNEICVIQRGMRFSVDVF-EE--TRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPVAWYE 235 house mouse
1EY2_A       262 DRQVPG-GYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFXVINSVAFDHADPSIFTVLTAKSVRPGVAIAD 340 human
CAB50930     240 DDESTPgPVEVVNKFCGNLWTAEYDHSPLDVVAWHGNHVPYVYDLRRFNVIGSISYDHPDPSIFTVLTSPSDTPGLAGVD 319 Streptomyces co...
Q9X4F5       252 DKET---PCRVQVKWCGSFHMVEIGHSPLDVVAWHGNYAPYKYDLKTFSPVGAILFDHPDPSIFTVLTAPSGEEGTANVD 328 Sinorhizobium m...
AAF36489     226 DRDVKD--FQVISKFQGRLFVAKQNHTVFDVVAWHGNYVPFKYDLSKFMVINSVSFDHCDPSIFTVLTCPSLRAGTAIAD 303 fruit fly
AAF61419     239 DLDV---EFTIINKYQGSWFQAKQGHSPFDVVGWHGNYVPYKYDLKKFMVINTVSFDHCDPSIFTVLTAPSVKHGTAIAD 315 Caenorhabditis ...
Q00667       241 DEEGPT-EYRLYSKFNNHLFSARQDHTPFDIVAWHGNYYPYKYDLGRFNTMGSVSFDHPDPSIYTVLTGPSDHVGTAIAD 319 Aspergillus nid...
WP_010920389 229 DIDT---PTQVIQKFQGALWAATWDHSPLDVVAWHGNLTPYRYDLSRFNTINTVSYDHPDPSIFTVLTSPSDTPGTANCD 305 Caulobacter vib...
O09173       236 DRRVPG-GYTVINKFQGKLFACKQDVSPFNVVAWHGNYTPYKYNLENFMVINAVAFDHADPSIFTVLTAKSLRPGVAIAD 314 house mouse
1EY2_A       341 FVIFPPRWGVADKTFRPPYYHRNCXSEFXGLIRGHYEAKQGG-FLPGGGSLHSTXTPHGPDADCFEKASKVKLAPERIAD 419 human
CAB50930     320 FVVFAPRWLVGEDTFRPPYFHRNVMSEYMGLIEGAYDAKAEG-FVPGGGSLHNMMSAHGPDRETFDRASAAELKPQRIDD 398 Streptomyces co...
Q9X4F5       329 FVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLIYGRYDAKEEG-FVPGGMSLHNMMLAHGPDFSGFEKASNGELKPVKLDN 407 Sinorhizobium m...
AAF36489     304 FVIFPPRWSVQEHTFRPPYYHRNCMSEFMGLILGKYEAKEDG-FAAGGATLHSMMTPHGPDVKCFEGASNAKLVPERVAE 382 fruit fly
AAF61419     316 FVIFPPRWGCADNTFRPPYYHRNCMSEYMGLITGCYEAKEGG-FKPGGGSLHSMMTPHGPDFNCFEMASNADLKPQRVAE 394 Caenorhabditis ...
Q00667       320 FVIFPPRWLVAEKTFRPPWYHRNTMSEFMGLITGNYDAKTGGgFQPAGASLHNIMSAHGPDMHAFEGASNADLKPTKIGD 399 Aspergillus nid...
WP_010920389 306 FVIFPPRWMVAEDTFRPPWFHRNVMSEFMGLIHGAYDAKAGG-FVPGGASLHNCMSDHGPDVASHKKATEVVLAPHKIDG 384 Caulobacter vib...
O09173       315 FVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIKGHYEAKQGG-FLPGGGSLHSAMTPHGPDADCFEKASKAKLEPERIAD 393 house mouse
1EY2_A       420 gTXAFXFESSLSLAVTKWG-LKASrCLDENYHKC-WEPLKSHF 460 human
CAB50930     399 -GLAFMFETRWPVTLTPQA-ARAE-HLQPGYDDV-WQGLERHF 437 Streptomyces coelicolor A3(2)
Q9X4F5       408 -TMAFMFETRFPQQLTTFA-AELD-TLQDDYMDC-WSGLERKF 446 Sinorhizobium meliloti 1021
AAF36489     383 gTQAFMFESSLSLAVTKWGeETCQ-KLDAAYYEC-WQALKNNF 423 fruit fly
AAF61419     395 gTMSFMFESSLNMAITNW--AVYQ-NVDKDYYKD-WQPLKKHF 433 Caenorhabditis elegans
Q00667       400 gSMAFMFESSLMVGVSEWGlKTCQ-KVQEEYNEHsWQPLKRHF 441 Aspergillus nidulans FGSC A4
WP_010920389 385 -TMAFMFESRWVFRPTHLA-LESA-ALQSDYDAC-WTGFPKAR 423 Caulobacter vibrioides
O09173       394 gTMAFMFESSLSLAVTKWGlKTCS-CLDENYYKC-WEPLRSHF 434 house mouse
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