Conserved Protein Domain Family
TMEM95

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pfam15203: TMEM95 
TMEM95 family
TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are typically between 102 and 231 amino acids in length and they have a conserved LGG sequence motif. TMEM95 is a sperm membrane protein required for sperm-oocyte fusion and is essential for mammalian fertilization.
Statistics
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PSSM-Id: 464560
Aligned: 9 rows
Threshold Bit Score: 233.136
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001128271  17 CVFCRLPAHALPSRLAQLNKQTEP--QEKECa---SSSSFLSISTDEVSMNQITEKTHRVLRVIEIKRSISLLPLYWQWL 91 
XP_017204366  17 CIFCRLPDRDLSGRLARLCSQMEA--QWKEW----ASPDFSAFALDEVTMNKVTEKTHRVLRVIEIKRSLSSLPPYWQWL 90 
P0DJF3        17 CIFCRLQDHALANRLAQLNNQTKPkwKWKEW----ASPDFSAFALDEVSMKQVTEKTHRVLRVIEKKGSTSLIPLYWQWL 92  house mouse
2_pfamImport   1 CIFCRLPDHGLSGRLHQLCSQMEA--QWKDCe---ASWNFPAFALDDTSMNKVTEKTHRVLRVVEIKGSLSPLPAYWRWL 75 
XP_010594872  17 CVFCRLPAHDLLSRLDRLCSQMEV--QWEACe---ASRDFSAFALDEVSMNKITEKTHRVLRVMEIKGSFSSLPLYWEWL 91 
XP_007483257  17 CIFCRLPSRDLSGRVAHLCDQISS--EWENCk---TSWNFSAFALDDVSMNRITEKTHRVLSIFEIKGSVFSLSSYWHWL 91 
XP_014345104  25 CVFCSLKYKNVENRFHQLCSGYMKtyNKTRCskymENTDFDDFAFHENKVIQITEKTHRVFRVLEINRSLADLPQYWDWL 104
XP_006105579  17 CLFCRLPAHGLSGRLARLCSQIEA--QWKDCe---ASWNFSTFALDEVSLNKVTEKTHRVLRVMEIKRSFSSLPLYWQWL 91  little brown bat
XP_023048975  59 CVFCRLPAHDLSGRLARLCNQMEA--GQKECg---ASPDFSAFALDEVSMNKVTEKTHRVLRVMEIKEALSSLPSYWSWL 133 Ugandan red Col...
NP_001128271  92 RKTKIPQYTREA-------L-CAPVCplfl----------lspaGGSTILYNCSTCEGKEESCWPQKRCFPGSHDLWDAR 153
XP_017204366  91 QKTLIPQYTREA-------L-CAPACllrp----------lspaGGSTILYNCSTCRSAEVSCWPRKRCSPGSHDLWEAR 152
P0DJF3        93 QKTRIPQYTREA-------L-CAPVC------------------RGSTILYNCSTCEGKEESCWPQKHCYPDSHDLWDAR 146 house mouse
2_pfamImport  76 QKTKLPEYNREA-------L-CAPACplvp----------lspaGGSTTLYNCSTCEGFEVHCWPRKRCFPGSHDLWEAR 137
XP_010594872  92 HNTKLPEYTREA-------L-CAPAC------------------RGSTTLYNCSTCEGVDVHCWPRKLCFPGSHDLWEAR 145
XP_007483257  92 QETKLPESVRQA-------L-CPPAC------------------RGITTLYNCSTCKAVEVQCWALKRCFPGRQDLREAR 145
XP_014345104 105 FEKKLVEYTHQV-------L-CPPTC------------------RGFVRTVNCTTCQREKVDCWDFKRCYPEKLSLQESV 158
XP_006105579  92 QETKFPEYNREA-------L-CSPACcevesglplpssvplspaGGSTILYNCSTCEGFEVLCWPQKRCFPGSHDLREAR 163 little brown bat
XP_023048975 134 RKIKLPEYTREAlcppacpLpLLSPA------------------GGSTTLYNCSTCKGMEVSCWPRKRCFPGSQDLWEAK 195 Ugandan red Col...
NP_001128271 154 ILLLCIFGIVLLLGALSLQVEY 175
XP_017204366 153 ILLLCVSGAALLLGVLSLLVES 174
P0DJF3       147 ILLLCIFGIVLLSGVVSLQVEY 168 house mouse
2_pfamImport 138 ILLLSVSGTVLLLGFLSLSVEY 159
XP_010594872 146 ILLFSVFVAVLLLSVLSLVVES 167
XP_007483257 146 ILLLSLSAALLILGFISCIIES 167
XP_014345104 159 YLLIIISVACFAIGTFSFFSEY 180
XP_006105579 164 ILLLCVFGTILLLGVLSLVVK- 184 little brown bat
XP_023048975 196 ILLLSVFGAVLLLGVLSLLVES 217 Ugandan red Colobus
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