Conserved Protein Domain Family
GCK
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pfam07802: GCK 
GCK domain
This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways (such as pfam00071) indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this family; this may indicate that these domains are able to interact with one another, raising the possibility that this domain mediates heterodimerization.
Links
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Statistics
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PSSM-Id: 429666
Aligned: 27 rows
Threshold Bit Score: 72.3636
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9LZL1        76 EDQKFVEFMKGGGCKESFTAWnDDCNfteEEAEK-NK---DLVTKCAGLFGTFSKCMDTHSDY--YHPILAVKKTTEEHL 149 thale cress
XP_009120280  53 EECSFCTYIKAGECKESWIEL-EKCL---DEAKKkDGe--SDVTKCKEARKMFKTCIYDNPVH--YEPVIAAETYMFAKM 124
Q9FKK9        82 GECPLCQFIKGGECKEAFTEL-ENCC---DEAKK-NNe--DHVSKCKEARLIFKTCMYDNPVY--YEPLLAGEARAMAKM 152 thale cress
Q9FKL7        51 GECRLCRFIKGGECKESFIAL-EQCV---DEAEEsGEe--SDFTKCKEVRAKFKTCMYENPVY--YEPILAGEARAIAKM 122 thale cress
XP_002892703 104 kakqVSEFMRD-PCRESIRSF-RR-----RDAEYtRNnntLTFHRKLEAFDTVYKCMEAHSDYnqYQAFLASMKRRYEYY 176
EFH69247      74 ieLRVSEFMIKGACKESFTAL-KDCV---DEAK-------SHPKKCDEFFPRLNKCMHAHSDY--YQPILALVKASEEMM 140
XP_002890572 104 RDEMFTKFMIRGDCKEAFMAW-NDFC---KEAKKnNKs--CLHTPTMD---TLFKCMKAHSDY--YHPLLTVFKNAEEHF 172
EFH66834     102 rDELLGKFITRGGCKEAFMAW-RDSY---EEAKK-NKg--SLYTPALN---TLSKCMEAHSDY--YQPLLAVVKNYEEHY 169
XP_002889961 121 lEEKVLAFMKGGGCEEQCTAW-RDCF---EEAEK-NKe--DVDIKCAGVHAMWFNCMDAHSDY--FHPFLAPLKTAGEDF 191
XP_002892784 178 EEERLLAMLKGGGCKESFMAW-LDCS---EEAEK-NKq--DFITKCAGVSAKLDKCLDAHSEY--YQPYFAVVKTAEEHM 248

Q9LZL1       150 EKE 152 thale cress
XP_009120280 125 LSD 127
Q9FKK9       153 LSE 155 thale cress
Q9FKL7       123 LNG 125 thale cress
XP_002892703 177 DKE 179
EFH69247     141 KKE 143
XP_002890572 173 KKE 175
EFH66834     170 SKE 172
XP_002889961 192 EKK 194
XP_002892784 249 ENE 251
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