Conserved Protein Domain Family
Pat_PNPLA_like
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cd07204: Pat_PNPLA_like 
Patatin-like phospholipase domain containing protein family
Members of this family share a patain domain, initially discovered in potato tubers. PNPLA protein members show non-specific hydrolase activity with a variety of substrates such as triacylglycerol, phospholipids, and retinylesters. It contains the lipase consensus sequence (Gly-X-Ser-X-Gly). Nomenclature of PNPLA family could be misleading as some of the mammalian members of this family show hydrolase, but no phospholipase activity.
Links
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Statistics
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PSSM-Id: 132843
Aligned: 10 rows
Threshold Bit Score: 319.297
Created: 2-Jan-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ## #                               #                                      
P41247         5 NLSFAACGFLGIYHLGAASALCRHGKKLVkdv---kaFAGASAGSLVASVLLTapekieecnqftykfaeEIRRQSFGAV 81  human
Q7Z6Z6        11 NLSFSGAGYLGAHHVGATECLRQRAPRLLqga---rrIYGSSSGALNAVSIVCgksvdfcc-shllgmvgQLERLSLSIL 86  human
ABN08447     148 GFSFSAAGLLFPYHLGVAHFLIQNGYIKEtt-----pLAGSSAGAIVCAVVASgasmeea---liatkilAEDCRKGGTA 219 barrel medic
CAG30362       9 SLSFAGCGFLGFYHVGATRCLSEHAPHLLrda---rmLFGASAGALHCVGVLSgipleqtl-qvlsdlvrKARSRNIGIF 84  human
Q96AD5         9 NISFAGCGFLGVYYVGVASCLREHAPFLVana---thIYGASAGALTATALVTgvclgeag-akfievskEARKRFLGPL 84  human
XP_970721      2 NLSFAGCGFLGIYHVGVACCFRKYAPHLLln-----kISGASAGAIAACCLLLdlplgett-sdilrvatEARRRSLGPF 75  red flour beetle
Q8N8W4        15 SISFSGSGFLSFYQAGAVDALRDLAPRMLeta---hrFAGTSAGAVIAALAICgiemdeyl-rvlnvgvaEVKKSFLGPL 90  human
EEC05448       2 NLSFSGCGFLGIYHVGVARIFLLPSPVIVyqgrlkcsVAMSIAAGPDAVLVVAgestty-----vlriavRARQRALGPL 76  black-legged tick
NP_741195     12 NLSFSGCGFLCVYHAGVAAAIKEYAPELLqn-----kILGASAGSIVACGLITgvcishat-stilkvvsQARSRTFGPL 85  Caenorhabditis ...
XP_001900538  20 SLSLSGCGFLSIYHAGVCAAIKEYAPQLLqn-----rISGASAGSIIAAGVICnvcishaa-rfflsvvsEIRSYTFGVL 93  Brugia malayi

Feature 1                                                                                        
P41247        82 TPGYDFMArlrsgMESILPPSAHElaqNRLHVSITNAKTR-ENHLVSTFSSREDLIKVLLASSFVPIYAGlkl-veYKGQ 159 human
Q7Z6Z6        87 HPAYAPIEhvkqqLQDALPPDAHVlasQRLGISLTRWPDG-RNFLVTDFATCDELIQALVCTLYFPFYCGlip-peFRGE 164 human
ABN08447     220 FRLGAVLRd---iLQKFLPDDVHIrsnGRVRVAVTQLLWRpRGLLVDQFDSKEDLINAVFTSSFIPGYLApkpatmFRNR 296 barrel medic
CAG30362      85 HPSFNLSKflrqgLCKCLPANVHQlisGKIGISLTRVSDG-ENVLVSDFRSKDEVVDALVCSCFIPFYSGlip-psFRGV 162 human
Q96AD5        85 HPSFNLVKiirsfLLKVLPADSHEhasGRLGISLTRVSDG-ENVIISHFNSKDELIQANVCSGFIPVYCGlip-psLQGV 162 human
XP_970721     76 NPSFNIHSlllegLEKFLPDDAHIrvsGKLHISLTRVHDG-KNVIVSQFDSREELIQALLATAFIPIFSGiip-pkFKGV 153 red flour beetle
Q8N8W4        91 SPSCKMVQmmrqfLYRVLPEDSYKvttGKLHVSLTRLTDG-ENVVVSEFTSKEELIEALYCSCFVPVYCGlip-ptYRGV 168 human
EEC05448      77 HPGFDINSiihdgLVKLLPDNAHLmcnGRLHVSLTRVSDG-KNVLLSHFDSREDLIQALKCSCFIPFYSGlrp-pkINGV 154 black-legged tick
NP_741195     86 HPEFNLLGivrdeLEVILPPNAYEmctGRLVISLTRWSDH-ENVIIDEYRSNADLIDAIMCSCFIPLYCGitp-pkFRGV 163 Caenorhabditis ...
XP_001900538  94 NRDFDLMKmvrtkLNAILPANAHElctGRLRISVTRFRDM-ENVILDEFCTKDELIDAICCSCFIPVYGGfvy-ptFRDE 171 Brugia malayi

Feature 1           #                                                                            
P41247       160 KWVDGGLTNALPilpvgRTVTISPFSGRLDIspqdkgqldly-vniakqdimlsLANLVRLNQALFPPSkrkmeslyqcG 238 human
Q7Z6Z6       165 RYIDGALSNNLPfadcpSTITVSPFHGTVDIcpqstspnlhe-lnvfnfsfqisTENFFLGLICLIPPSlevvadncrqG 243 human
ABN08447     297 LCIDGGLTLFMPptsaaQTVRVCAFPAGRMGlqgigisp--------dcnpenaSSPRQLLNWALEPAEdvildrlfefG 368 barrel medic
CAG30362     163 RYVDGGVSDNVPfidakTTITVSPFYGEYDIcpkvkstnflh-vditklslrlcTGNLYLLSRAFVPPDlkvlgeiclrG 241 human
Q96AD5       163 RYVDGGISDNLPlyelkNTITVSPFSGESDIcpqdsstnihe-lrvtntsiqfnLRNLYRLSKALFPPEplvlremckqG 241 human
XP_970721    154 RYMDGGYSDNLPtl-deNTITVSPFCGESDIcprddssqlfh-iniantsielsKHNIYRIMRILFPPNpevlsnmckqG 231 red flour beetle
Q8N8W4       169 RYIDGGFTGMQPcafwtDAITISTFSGQQDIcprdcpaifhd-frmfncsfqfsLENIARMTHALFPPDlvilhdyyyrG 247 human
EEC05448     155 AYMDGGFSDNLPml-deNTLTVSPFAGDSDIcpiddsfnlmq-infsntsitlcPGNLYRASRIFFPPHpeilsrmcqqG 232 black-legged tick
NP_741195    164 QYIDGGVSDNQPiy-deHTVTVSPFSGESDIcppdwdsgsmlgvdfngtsirftTRNMFRLMACLWPRStddlsrmclqG 242 Caenorhabditis ...
XP_001900538 172 IYIDGGASDNQPvt-dtDTITVSPFSGESDIcptdeesaslfewnfagtsirltANNLYRAALCLFPPSaeecasmcrsG 250 Brugia malayi

Feature 1                  
P41247       239 FDDTVKFLLK 248 human
Q7Z6Z6       244 YLDALRFLER 253 human
ABN08447     369 YLDAAVWAKE 378 barrel medic
CAG30362     242 YLDAFRFLEE 251 human
Q96AD5       242 YRDGLRFLQR 251 human
XP_970721    232 FDDALRFLHR 241 red flour beetle
Q8N8W4       248 YEDAVLYLRR 257 human
EEC05448     233 FDDAVRFLQK 242 black-legged tick
NP_741195    243 FGDALRFLTK 252 Caenorhabditis elegans
XP_001900538 251 FNDALKFLVN 260 Brugia malayi

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