Conserved Protein Domain Family
MDM1

?
pfam15501: MDM1 
Nuclear protein MDM1
This family of proteins is present in the nucleus. The function of MDM1 is not known.
Statistics
?
PSSM-Id: 464751
Aligned: 20 rows
Threshold Bit Score: 317.547
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_008254986    9 SEYQRNFLWKKSylSESCNSSGGQRHPWAGLRSDQLGITKEPSFISKRRVPYHDPQISKSLEWNGAI-TENKVVASPEPE 87  
XP_015137163    9 SEYKRNFRWKTP---ELCSPSQEQKSPWAGLRSDQLGITREPNFISKRRVPYHNPQISKSFEWTGDCdSDD----PVETE 81  
XP_027311832   48 SEYKRNFRWKTP---ELCSPDQEQKSQWAGLRSDQLGITREPNFISKRRVPYHNPQISKSFEWTADCdLDD----PLETE 120 
NP_001123739    9 SEYDRNYTWKNH----EDLEQEPTCSRWAGLRSDELGISKEPRFPSKRRVPYYKAQISKSFQWKE---PRDNGYNISESI 81  
EEN57775      604 SEYDTNYKWLESrkSAAYQPTREELAREAGLRSAELGILHEPQMQAKKRVGTYAPTVPFALEWEDPLqPPDVVISKDPPV 683 
EDO38986        9 SEYHANFKP------------------------FEVQLNKEPKF------------------------------------ 28  
EKC42562      177 AALRQKFSKLD----------------------REGGRKTAPSALRQSKEQYSK-------------------------- 208 
XP_009298418    9 SEYRSKYKGRTS---RSRSDSPHRRMRLAGLRSDQSGITQEPQFISKRRVPFYPSQVSSSFRWEGRDhSQQQLEKSRSPA 85  
XP_015208393   28 TEYKKRYGWKDS----GSPVSPDLRAPGAGLRSDQLGITKEPSFTSKKRVPFYRPLISRSFQWEQGDgSERSQPAAAEER 103  spotted gar
XP_008114801    9 SEYKRSFKWRKPdkSKPCSPILEEKCQWAGLRSDEFGISREPKFLSKRRVPYHNTQVSKSFEWNGGNdSEKD---TAEPE 85   green anole
XP_008254986   88 APETP-------------KPQEVE---GVSQQGVL------PLEAPRVSKRTRSHSADSRAEGSSDVVDDNEGVKRDHEL 145 
XP_015137163   82 ALKTA-------------ES-LAEhsnDVNQENTE------TPEGPRLPPKVRSHSSDSGVETALALAGNSMKKTPPVAP 141 
XP_027311832  121 VLKTA-------------ELH-ADrnnDVNQEKIE------TPEGPRLPPKVRSHSADSRVETAPALPENNMKRSPTVPP 180 
NP_001123739   82 MEEPV-------------QLRLDLdreSLAEEKLH------TPDAPRLSEKANNYAVSSKM---VKDVGSTVKKTAIEAP 139 
EEN57775      684 TEKVReslekmktykiekKLREKEkrrREEKRRLEekydppTPPAPR-PDKTRERPREEPRERPRERPREERGPERKPTK 762 
EDO38986       29 -----------------------------------------SPAKPKVQETK---------------------------- 39  
EKC42562      209 -----------------------------------------TIDDNRMESAVKSWVKDKNVGSMNEFAQTNLDK------ 241 
XP_009298418   86 VSPVL-------------RATSA--------ERQV------TPLAPRDPPE-----------------GTTAPSQPPQAE 121 
XP_015208393  104 PLSP---------------------------ERTE------TPPAPRVPRLPRSPSEDLNPQPFPVANGKNLPSSDPD-- 148  spotted gar
XP_008114801   86 LHLSL-------------ESHSSEsrdDTTQEKIK------TPDAPRIPEKLHSSSPGSRSELAVALAKS--KRSPPITP 144  green anole
XP_008254986  146 VT-----------EHEELELSTK-LPSENVDNRLDRLLRKKAGL--TVVPAHNALRNSEYQRQFVWKTSKD-TAPVFPAH 210 
XP_015137163  142 PN-----------QKEAFVSPKK--EAEKVNNGLHRVLQRKGGM--NTPHLSTFPRNSEYQSQFVWKSPHE-KSPILAAE 205 
XP_027311832  181 PN-----------KNEAFVSSKK--ESEKMDNGLHRVLQRKAGM--NIPRLNTFPRNSEYQSQFVWKSPHE-KSPILAAE 244 
NP_001123739  140 ED-----------NRETVAPSKK-VNSQAKANGVHRVLKKKAGL--STAPLQHPLKMSEYRRQFERKTPTE-NSPMLAAE 204 
EEN57775      763 ERgqgdkarqkqgDKKEEKGGKKdEGKEEKKEKRNRALEMKAGV--KGERRKIPTMLSEYQRQFYEQQKLKdESPVMAAD 840 
EDO38986       40 -------------VAETLHKSSH-NTHNHEDDKENRALEYKAGLapAMPRTKKQRYVSEYQKQFYWKKPVGrEAPILSAE 105 
EKC42562      242 -------------GIADSAPEAP----------ADYALRYKTGV---SVPRPRRHKFSEYQKSFSWKDGAK-ASPVLAAE 294 
XP_009298418  122 AA-----------QTSTFAVQKQ----KQALNGINHALRMKAGL--RSEHQRNGL-NSEYQRQFMWKTPVA-ESPLLAAH 182 
XP_015208393  149 -------------KHCPTRTAAAaERSDAGLDGVHRVMQKKAGL--KSTVRRSAAQNSEYQRQFSWKTAPV-SSPLLAAE 212  spotted gar
XP_008114801  145 VK-----------EKRTITPTEK--DLEKINKGLKRVLQRKAGM--DIPRSCSFPRSSEYQRQFVWKTPQK-LSPVLAAD 208  green anole
XP_008254986  211 QVFHSKSK-FVPQFKGN--SVIHETEYKRNFKGLS--PVKEPKLRTDLKENG-------------------IRETLSPek 266 
XP_015137163  206 EALYNVSK-PVPPLKSP--AITSETENVRNLKGSP--AAKGPQEKCS-EEKE-------------------FLVHEQ--- 257 
XP_027311832  245 EVICNMSK-SIPPFKSP--AITSETEHERNFKDSP--PAKSPQERCCSEEKE-------------------FLVCEQ--- 297 
NP_001123739  205 QVIYNKNK-SIPPFNVD--ALKTETEYKSRFKGSP--PAKGPVLRKDWEEKH-------------------VPKYEPEdp 260 
EEN57775      841 QMVYNSNP-AMAPYRSD--LIPRATEYNRQFKVPK--RVAVAESVSSDRSRD-------------------RRKKSKSsk 896 
EDO38986      106 KVVFSSQD-NLPPAKPVkiSMPTKSEYQLQFVKYP--LVTTLRDDECAGSQG-------------------KEKEAGA-- 161 
EKC42562      295 QVVYNSNPaLVPPQK----SFVKDSEYAAQFKQYNamPVSSDDLKAIPRAEK-------------------PRSKVKRsk 351 
XP_009298418  183 QMLYSNNR-AIPPFKTN--PVIMESEYKRSFKGSP--LPRPPRLRRDVEQYE-------------------VPEFLTEsk 238 
XP_015208393  213 QVIYNRNR-DVPPFKSD--AVVLESEYKKNFKGLV--LPKGPRLRRDVEEREavlyepenispdktpkskkNKKGGST-- 285  spotted gar
XP_008114801  209 KFIHSTSP-SIPPFKSP--VIIPETEYERSFKASS--PAKEEKQQNSLEERE-------------------RPAAEPVea 264  green anole
XP_008254986  267 ---kcNKT---DTPLKL-EAEMASKDSNQPKKKLTPWRH----Qr-----------lGKVNSEYRAKFLSPAQYFYKAGV 324 
XP_015137163  258 -----TKR---EELIQK-PAEDASKQEKSEQKHPKRKNK----QhisqkplslhthrGKMNTEYRSKFLSPAQYFYKDGA 324 
XP_027311832  298 -----RKR---EEPLHK-PAEDASKQGKAEQKHPKQKNK----QhinqkplslrtnrGKMNTEYRSKFLSPAQYFYKDGA 364 
NP_001123739  261 sikrkEKRiqiNEAICS-PPKNDKSETEAKQRIHARKHK----EkviqqlkhsskscRRIKSEYTSNFLSPSEYLYKDGA 335 
EEN57775      897 ----kERRarsLSPERLpPAGKPTEFMPVVWNDPRPIKNfgylKksphkldnphpknWNWRSEYHSNYKSPTSFEYRGGT 972 
EDO38986      162 -----NKKaelQPPAGV-ASSPDKQQTPLPLAPEVPYKP------------------MKFQSEYHTNFQPPSMFDYIDGA 217 
EKC42562      352 stgalRVD---KRPAAGsGPLITPDNKRQTIESELQGEP----QdapssppihqgnlKRPRSEYTSNFRSPTKFQY-DGA 423 
XP_009298418  239 tpeksKRKkkkKERPHSrKSSPEQEVAYLQQQEVKSPHNlkdps---------pkvmRKGKTEYRSNFHSPLQYSYKDGA 309 
XP_015208393  286 -----KHNntsSVPHPRrERERQVSRKQNPKRPFFPHRGc-----------------GKQKSEYSANFRSPLLYRYKDGA 343  spotted gar
XP_008114801  265 ssgekCEK---TEVFSK-ATEDPSKQSKSEKKQKQPKQK----Hkplcl----hrsfRKMNTEYRSNFLSPAKYLYKDGA 332  green anole
XP_008254986  325 WTRVKENVPNQG-------------------SLNAMWYAEVKELREKAEFYRKRVQGTHFSRDHLNQIVSDNNRCWDV-- 383 
XP_015137163  325 WSRIRSKVPNQAsq----------------nPLNSMWYMEVRELRARAKAYRQRIEGTHFSRYHLNQLLSDNNSLWDV-- 386 
XP_027311832  365 WSRIRSKVPNQAsq----------------nPLNSMWYMEVRELRARAKAYRQRIEGTHFSRYHLNQILSDNNSLWDV-- 426 
NP_001123739  336 WVRAKKQMHEQ-----------------------------INELREKADYYRRREQGTHFSRNHLNQILSVNNKFWDV-- 384 
EEN57775      973 WRGADPPHLQPR---------------------------KVMELRKKADDYRRRSHGTHFSRDHLLQLMARQNDMWDQ-- 1023
EDO38986      218 WVGADPPHLYPLekps-----------ddvhPVTLSWFKQVTELRNKAQSYKTRARGDSQFLGILKSLEEQQSITLEK-- 284 
EKC42562      424 WHGADPPHLQPTrepekekpvkksgpvedsaPALSNWFAEVIELRRKAAEYKKRAQGTHFSREHLVQLIAQQNQAWDNls 503 
XP_009298418  310 WLKIKSAKEEGC-------------------DGFHEWYHEVKELRERAEAYKKRAWGTHFSRQHLNQILSDQNWMWEP-- 368 
XP_015208393  344 W--IKSPCVGE----------------------------EVKELRERAEAYKKRAWGTHFSREHLSQILSEQNRLWEVn- 392  spotted gar
XP_008114801  333 WIRIKRNMPDQ-----------------------------VKELREKAEAYRQRVRGTHFSRDHLNQILSENNKLWDL-- 381  green anole
XP_008254986  384 --SSTT-SS------EGTISSNIRALDLA-------------------------GEPTVPKTLQ------KCPSTKLEEK 423 
XP_015137163  387 --SSNS-SS------EEGISNDIRALDLA-------------------------GVSE-----K------ETAPRPKMLQ 421 
XP_027311832  427 --SSSS-SS------EEGISNDIRALDLA-------------------------GVAE-----K------ETAPRPKMLQ 461 
NP_001123739  385 --SSNS-SS------EEQVSHNIKALDLA-------------------------G--------F------QAHSKKENVH 416 
EEN57775     1024 --SESK-ST-------------VSALSLA-------------------------SDPVDKGHAR------RHQPPKRSAH 1056
EDO38986      285 --ANKR-TPsaqhrlRDDEANRVPDMRIEclee-----------------rqekAQPVSDHMIR------KAETGNQEKR 338 
EKC42562      504 taRSGS-STlsalslESGASAKLRAQKIElsekpllkienidtnnetldnelckGVRKSNDKMQ------QLKADPVVME 576 
XP_009298418  369 --SSGTsSSsieseaCRSTSHIIEALDLA-------------------------RAGSVRESSS------PGHSASVVVS 415 
XP_015208393  393 --SSST-VT------EDTVSDTVNALDL-----------------------------ARARDVKrspspvSPGSLSPVGN 434  spotted gar
XP_008114801  382 --SSNS-SV------EDVISNNVRALDLA-------------------------GVPE-----E------KLSPGPKFMP 416  green anole
XP_008254986  424 GQILEEQPQTNTTEQLGMSGAPTIPV---------RRRLAWD-AED---TGEDKQKQPRGEKEEEEEEeeeekekekekg 490 
XP_015137163  422 QPGSREQSHQDDTEKKGLSDAPTVPV---------KRRLVWGeQEG---TAEKDSQQLTEEEEKENEQ------------ 477 
XP_027311832  462 EPNAREESHENGPEKKDMSNASTVPV---------KRRLVWDeQEA---TEEKENQQSTEEEEKENEK------------ 517 
NP_001123739  417 KSSIEE---NEDTGTLGISDVPTVPV---------RRRLAWD-ENN---NSELAQERAALTVEDKNVEt----------- 469 
EEN57775     1057 P---AEKPRPRHRSISSSPEEEKRPV---------QRKLAWD-EQG---GGDRASSIGSIPSQGRGSH------------ 1108
EDO38986      339 NEFSG----KNNNNEHGIHLVPTDDRasidqgsghRKREAWAePGP---IYPRAAIPPYGVSESLPTS------------ 399 
EKC42562      577 TKFNNKLRLETKKENTNHRNVKTKSK---------KVEMANKiEDDvslMAHEGSDEEQGKPDFVPEKhmdlttkqrykk 647 
XP_009298418  416 R--------RSSSGEVGLPEEPTLPV---------QRKLAWDeEEQ---LGEREEIVQDRLTDKEGKT------------ 463 
XP_015208393  435 AKSRTE-----ETEQAGLHSRPTLPV---------QRRLAWEqEDRgpeSKGEEQGEHTGDLGRQEEEq----------- 489  spotted gar
XP_008114801  417 QPELSAEFQENSTGKLGMSDAATLPV---------KRRLVWGePDN---GEQLEHQTPVLGGGGNDEEk----------- 473  green anole
XP_008254986  491 grDKQVYSGHLEKLDAQ---------EK-SKADKIKEG-------------SDSSSeSSSG---TGGRLPTPKLRELGG- 543 
XP_015137163  478 ------AAVVTQNLEKN---------NEgINEDNRIEGentcll-nspaavSESSS-VSSE---PGGRLPTPKLRALGR- 536 
XP_027311832  518 ------AAVVVQNLEEN---------NKeTNEDNKVEGenalll--nsaavSDSSS-VSSE---PGGRLPTPKLRALGR- 575 
NP_001123739  470 --TDADVVEDAEEMHAI---------SEeVKRPDRLHStttnp----svdgLECIS-LPSE---EGGRLPTPKLKEFGL- 529 
EEN57775     1109 ------------ASASY---------SEnTSTATLIEG---------------------DD---DDGRVATPELKQVHAp 1143
EDO38986      400 --RSASSIGSDSMSDVT---------LTdDLMNERPRS--------------------TPD---DKMRKPTTGLGDVA-- 443 
EKC42562      648 sqSRKKAWQEMDESRDYrqddlslmvQEgSERRAKSRGrkkhrsrrarrreQEEASeVTPDfpsDTGRIPTPKMRSKSA- 726 
XP_009298418  464 --RNENGMERNERLNSL----------EsESLSSAEEG-------------SEASV--------NGGRLPTPKLKTMQT- 509 
XP_015208393  490 --ADGNKKGDDAQAGQQ---------QKeVKATEQRSSsrss------sdvTAGSSeTSSD---GGGRLPTPKMKTSGV- 548  spotted gar
XP_008114801  474 --ENKQESEDIKEPDKN-------------STGNDHQGenvns---psanrADCSSgSCRG------RLTTPELKAHGG- 528  green anole
XP_008254986  544 IQRTHHDLTTPAVGGAVLV-SPSKVK 568 
XP_015137163  537 AQRTHHDLTTPAVGGAVLV-SPPKFK 561 
XP_027311832  576 AQRTHHDLTTPAVGGAVLV-SPPKLR 600 
NP_001123739  530 SQRTHHDRTTPSTGGALLV-SPMKEH 554 
EEN57775     1144 VRRHHYDRTTPAIGGALLVkSPPPAR 1169
EDO38986      444 IQHAQGE-------GAVGI-DPPRVS 461 
EKC42562      727 GARHHLDRTTPVVGGAMLS-SPPRPE 751 
XP_009298418  510 VQRTHHDRTTPSIDFNLHY-IAKAAN 534 
XP_015208393  549 AQRTHHDLTTPATGGAILV-SPPKQK 573  spotted gar
XP_008114801  529 AQRTHLDLTTPATGGAILV-SPSKVR 553  green anole
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap