2ZX2,2ZX0,2ZX0,2ZX2


Conserved Protein Domain Family
Gal_Rha_Lectin_CSL3_rpt1_rpt2-like
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cd22832: Gal_Rha_Lectin_CSL3_rpt1_rpt2-like 
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first and second galactose/rhamnose binding lectin domain found in Oncorhynchus keta L-rhamnose-binding lectin CSL3 and similar proteins
The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1-3. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. CSL3 has hemagglutinating activity towards rabbit erythrocytes, human type A erythrocytes, human type B erythrocytes, human type O erythrocytes, and sheep erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. Members in this family contain two tandem galactose-binding lectin domains. This model corresponds to the first and second galactose/rhamnose-binding lectin domains found in Oncorhynchus keta CSL3, as well as the second galactose/rhamnose-binding lectin domain found in Oncorhynchus keta CSL2.
Links
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Statistics
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PSSM-Id: 438689
Aligned: 10 rows
Threshold Bit Score: 152.645
Created: 4-Jan-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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rhamnosehomodimer
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:rhamnose binding site [polypeptide binding site]
Evidence:
  • Structure:2ZX2; Oncorhynchus keta CSL3 in complex with rhamnose; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                                                                   #    #
2ZX2_A       101 ISSIICEGSDSQLLCDRGEIRIQRANYGRRQHDVCSIGRPHQQLkNTNCLSQs-tTSKMAERCDGKRQCIVKVSNsVFGD 179 chum salmon
2ZX0_A         1 AISITCEGSDALLQCDGAKIHIKRANYGRRQHDVCSIGRPDNQLtDTNCLSQs-sTSKMAERCGGKSECIVPASNfVFGD 79  chum salmon
2ZX0_A       101 ISSIICEGSDSQLLCDRGEIRIQRANYGRRQHDVCSIGRPHQQLkNTNCLSQs-tTSKMAERCDGKRQCIVKVSNsVFGD 179 chum salmon
2ZX2_A         1 AISITCEGSDALLQCDGAKIHIKRANYGRRQHDVCSIGRPDNQLtDTNCLSQs-sTSKMAERCGGKSECIVPASNfVFGD 79  chum salmon
P86178       100 TRSITCEGSDAPLECDEGTIQIHSANYGRRDQLVCSFNRPANQLaNTNCLSQsitTSKSAERCNRKSQCDVPASNsLYGD 179 chum salmon
P86179       101 ISSIICEGSDSQLLCDRGEIRIQRANYGRRQHDVCSIGRPHQQLkNTNCLSQs-tTSKMAERCDGKRQCIVSVSNsVFGD 179 chum salmon
P86179         1 AISITCEGSDALLQCDGAKIHIKRANYGRRQHDVCSIGRPDNQLtDTNCLSQs-sTSKMAERCGGKSECIVPASNfVFGD 79  chum salmon
XP_015195188 104 ERSVTCEGGTAELDCGDKAIRIENANYGRRDRYLCSSGRPADQLtNVQCVLSg-tLGLLRKRCDGNTQCTVPATNdVFSD 182 spotted gar
XP_019712615 130 MTVVACQGAMAHLDCGLGHVTIDGAAYGRRDQTTCSEGRPFDQRqNVNCLEPs--TSLVVKMCKGKSTCSVPASNaMFTN 207 tiger tail seah...
XP_028970030 124 KSSIACEGSNIQLECGKGKIHIQTANYGRSNTHVCSSGRPSNQIlNINCVNKp-tTSKMVQSCNGKAQCVVEASKsVFGD 202 northern pike

Feature 1         ######        
2ZX2_A       180 PCVGTYKYLDVAYTC 194 chum salmon
2ZX0_A        80 PCVGTYKYLDTKYSC 94  chum salmon
2ZX0_A       180 PCVGTYKYLDVAYTC 194 chum salmon
2ZX2_A        80 PCVGTYKYLDTKYSC 94  chum salmon
P86178       180 PCVGTYKYLDVAYTC 194 chum salmon
P86179       180 PCVGTYKYLDVAYTC 194 chum salmon
P86179        80 PCVGTYKYLDTKYSC 94  chum salmon
XP_015195188 183 PCVGTYKYLDVTYTC 197 spotted gar
XP_019712615 208 PCQGTYKYLEISYVC 222 tiger tail seahorse
XP_028970030 203 PCYGTYKYLEVTYTC 217 northern pike

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