Conserved Protein Domain Family
bHLH_SOHLH1_2
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cd18908: bHLH_SOHLH1_2 
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family
The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation.
Links
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Statistics
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PSSM-Id: 381478
Aligned: 12 rows
Threshold Bit Score: 82.7728
Created: 24-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Saccharomyces cerevisiae bHLH domain of PHO4 (1AOA) binds DNA.
  • Citation:PMID 9303313
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ######  ## ##                        ##                     
Q9NX45       201 KISLLHSSKEKLRRERIKYCCEQLRTLLPYv--kGRKNDAASVLEATVDYVKYIREKISPA 259  human
Q5JUK2        53 SCLRRNVISERERRKRMSLSCERLRALLPQf--dGRREDMASVLEMSVQFLRLASALGPSQ 111  human
XP_007900979  96 KTDKINVIKERDRRKRIKTSCDHLRDLLPNf--eGRKNDMASVLEMTVKYLELVQVLIPPQ 154  elephant shark
ESP04910     314 CMAADHTIKEKMRRERIKDSCDQLRVLLPYi--rGRKTDMASILEMTVDYLKLITSSLPPD 372  owl limpet
XP_014352701  85 LKAQLHSKKEKMRRDRIKDCCDQLRTLLPYv--kGRKNDAASILEMTVDYIRFIRDRIPQM 143  coelacanth
KII69718      27 IGNIRHNSKEKHRRERIKNSCIIMRQMLPQdiqqSVKLDMASVLELIVQYLSYIQRSIPHY 87   Thelohanellus kitauei
KXJ18712     449 DDLSKHSSKERIRRERIKESCDRLRYLLPNi--sGKKTDMASILEMTVKFVKLINDRIPPA 507  Exaiptasia pallida
XP_012555209 323 DDVTKHSTKERLRRERIKECCDQMRDMLPRysghTRKIDMATVLELTVLYIRVIQMHSPAV 383  Hydra vulgaris
XP_015197336 165 NEAFLHSRKEQKRRLQIKKCCNHLRDLLPFl--tKKRVDTASVLEMTVKYIKYLQCRVPEE 223  spotted gar
XP_007889452 193 VDALVHSTKERMRRERIKACCVQLQALLPHv--kGRQTDVASILEMTVEYIRYICERIPKP 251  elephant shark
KKF12762     359 MKTSSCVLLERRRRKRITQSCSTLRQLVPTi--hGVHVDMVTVLETTVAFLKTVQEVVQAE 417  large yellow croaker
ABK25719      68 SSKESQTLAEQLRRKRMKSLCTQLESLLPAt---PAKLDRCGLFEETINYIRKLEENIHRL 125  Sitka spruce

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