3PBL


Conserved Protein Domain Family
7tmA_D2-like_dopamine_R
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cd15053: 7tmA_D2-like_dopamine_R 
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D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.
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Statistics
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PSSM-Id: 320181
Aligned: 11 rows
Threshold Bit Score: 305.039
Created: 13-Nov-2008
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:3PBL: Human dopamine D3 receptor in complex with a D2/D3 selective antagonist (eticlopride), contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                    #   
3PBL_A        39 AYYALSYCALILAIVFGNGLVCMAVLKERAlqttTNYLVVSLAVADLLVATLVMPWVVYLEVtggvWNFSricCDVFVTL 118
XP_001087197  31 AAALVGGVLLIGAVLAGNSLVCVSVATERAlqtpTNSFIVSLAAADLLLALLVLPLFVYSEVqggaWLLSprlCDALMAM 110 Rhesus monkey
EMC78343      45 NYYAMLLTLLIFVIVFGNVLVCMAVSREKAlqttTNYLIVSLAVADLLVATLVMPWVVYLEVvg-eWRFSrihCDIFVTL 123 domestic pigeon
XP_002731088  31 NYWSLFIILFSLVTVFGNVLVCLAVFREKSlrniTNYFIVSLAVADLSVGLLVMPVAIYVEInggfWYLGhtlCDFWVTM 110 Saccoglossus ko...
CCD58583      71 QYWAMILLIFPLFTVFGNVLVVLSVFRDQSlhtaTNYFIVSLAIADISLAIVVMPVASWVEAnngkWRLGtvlCDIFIMF 150 Schistosoma man...
Q8IS44        77 NYWALILILFPILTLFGNILVILSVCRERSlqtvTNYFIVSLAIADLLVAVVVMPFAVYFLVng-aWALPdvvCDFYIAM 155 fruit fly
ABI64137     123 NYWTLLLLLFPVFTVFGNILVLMSVYRERSlqtvTNYFIVSLALADLLLASIVMPFAVYYLLmcgyWGLGpivCDLYIAM 202 California spin...
Q6RYS9        22 VAAGVFLPLVPTMAVFGNVLVIMSVFRERSlqtvTNMLIVSLAVSDFMVAIGVMSFGVYYEWndfkWGLGsffCHVYQAL 101 nematode
NP_001024048  38 NYAGLSLIVIPLITLLGNLLVIISVLRYRAlqsaINFLILGLAVADLLVAIIVMPYAVYVYVtngdWYLGnlmCDIYMAS 117 nematode
AFC88981     111 VYWALMLVILPFLAVFGNILIILSVYKERSlqtaTNYFIVSLAFADLLVAAAVMPFAVYVLVnv-dWELSetlCDFYIAV 189 southern cattle...
EFV59979      39 HFYALALLIIPSLTIFGNVLVIASVCRFRNlqcpINYFIFGLAIADLMVAVLVMPFAVYVEFnnrkWELGallCDLYCAA 118 Trichinella spi...

Feature 1        ##  #                                                                          #
3PBL_A       119 DVMMCTASIWNLCAISIDRYTAVVMPvhyqhgtgqssCRRVALMITAVWVLAFAVSCPLLFGFnttg------dptVCSI 192
XP_001087197 111 DVMLCTASIFNLCAISVDRFVAVAVPlryn---rqggSHRQLLLIGATWLLSAAVAAPVLCGLndvrg----rdpaVCRL 183 Rhesus monkey
EMC78343     124 DVMMCTASILNLCAISIDRYTAVAMPmlynt--ryssKRRVTVMIAVVWVLSFAISCPLLFGLnnt-------denECII 194 domestic pigeon
XP_002731088 111 DVMSCTASIFNLCAISLDRLYAVSKPlqya---rqrsTQRALVTIAIVWMISFIISCPVLFGVnnvpn----rvpeLCIL 183 Saccoglossus ko...
CCD58583     151 DVLLCTASILNLAAISMDRYVAVTRPitya---qhskNVRVGITITVTWILSFVIALPIACGLnnapy----rnleICVM 223 Schistosoma man...
Q8IS44       156 DVICSTSSIFNLVAISIDRYIAVTQPikya---khknSRRVCLTILLVWAISAAIGSPIVLGLnntpn----repdVCAF 228 fruit fly
ABI64137     203 DVVCSTSSIFNLVAISIDRYIAVTQPikya---qsknNKRIVFTIAIIWVVSAAIGIPLFFVNqwdvakrqdvltnDCNF 279 California spin...
Q6RYS9       102 DVACSTASILNLLAISLDRYIAIGHPisyaq--ygarGGRAMISITIVWGVSVAVALPLLLGVnpmee----ndlqECEL 175 nematode
NP_001024048 118 DVCCSTASILLLAVISFDRYRAVSLPiqysr--qsqnVKRVWTLIAVIWLVSLTLASPMVFGVnvrpp---danpyECRF 192 nematode
AFC88981     190 DVTCSTASIFNLVAISIDRFIAVTQPikys---khknSKRVALTIVIVWVVSAAIGSPIMLGLntspq----rvphLCIF 262 southern cattle...
EFV59979     119 DVVCSTASIILLTVIGFDRYIAANHPiryvt--npknVKYVVTINISVWAVSALIACPLVLGLnnvey----reekECRF 192 Trichinella spi...

Feature 1             #  ##                                                                      
3PBL_A       193 sNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLkqrrrknifemlrideglrlkiykdtegyytigighlltkspslnaak 272
XP_001087197 184 eDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLrrwevarraklhgraprrpsgpgppslvprlpqdpcgpdcappaprlp 263 Rhesus monkey
EMC78343     195 aNPAFVVYSSIVSFYVPFIVTLLVYVQIYIVLrkrrkrvntkrsshgldsdtqaplkdkcthpedvklctvivksngsfq 274 domestic pigeon
XP_002731088 184 fNGPYMVWSSVFSFVIPAFIMSIVYILVYVAIknrvtrigiggttmakhnrtevsdlpqsdeptqdtvhepdpt------ 257 Saccoglossus ko...
CCD58583     224 yIPEYIIASSIGSFYVPCTIMIVLYYQVFKAIklrtkrsklisirnqvqnyakrcetvnqtsvipikdkevnifssleni 303 Schistosoma man...
Q8IS44       229 yNADFILYSSLSSFYIPCIIMVFLYWNIFKALrsrarkqraarkphlseltggsvieniaqtrrlaetaldssrhasril 308 fruit fly
ABI64137     280 lNADFILYSSISSFYIPCIAMIYLYYRIFKALkerakmkkpkvseikagsvienvaqtrmlaettlgtevalpptkssal 359 California spin...
Q6RYS9       176 aNPYFNMISSIFSFFIPCIAMIILYTIIFRRLrqrerarslrqaqrsendkissallggaqiarqmgkhfknrtdqille 255 nematode
NP_001024048 193 yNAEFSILSSMISFVIPCFLVLFVYIRIIIALkkrekaakmrrekntiahgltmrpdtgeeqvdeeaagrivagpvvnvm 272 nematode
AFC88981     263 yNSDFILYSSLSSFYIPCLVMVFLYYKIFRVIherarkavgkkearlkglvleggpppianntahhgvvtlavgagggat 342 southern cattle...
EFV59979     193 yNADFIIYSSIISFWIPMIVMLYFFACTYLQIrrqsklaqrrrrgvrqalqrqdcvreqrfismkkrlqlafvekngqnd 272 Trichinella spi...

Feature 1                                                                                        
3PBL_A       273 seldkaigrntngvitkdeaeklfnqdvdaavrgilr------------------------------------------- 309
XP_001087197 264 qdpcgpdcappapgppqg-------------------------------------------------------------- 281 Rhesus monkey
EMC78343     275 vnkrkveveshieememvsstsplektt---------------------------------------------------- 302 domestic pigeon
XP_002731088     --------------------------------------------------------------------------------     Saccoglossus ko...
CCD58583     304 tyltafnpqvcdcqssgigtyidsshitnmsyctenhhsykandindqyltdfngtsnlssncspniysetisnsvepse 383 Schistosoma man...
Q8IS44       309 pdeaatntasgsneeedenaispdiddchvivn----------------------------------------------- 341 fruit fly
ABI64137     360 idedkntnntsnsqdeeeeegedvmglggeenchiiknpkpeelnlaplkegete------------------------- 414 California spin...
Q6RYS9       256 isfqtssfptmsessedastispminsfnnflpkktpypstsipaipecgsmpnltiierpeaekekeisimdlrdtvem 335 nematode
NP_001024048 273 maalpsmtrrmrqferhrraielagdeeweedeldvmdeccggddagdddddyhadngqgvveasaprttsmlrriinaa 352 nematode
AFC88981     343 ggqpaqggqpslgdnrngnkslqvssmvpeadpltantgsgsqpdedefddlpteaggdkw------------------- 403 southern cattle...
EFV59979     273 agtnnnntatnnnslrfspnslellkrrtdhlpedslaeysfamsgdsvvtvdpqssgsppsgkaalqitcdakstescs 352 Trichinella spi...

Feature 1                                                                                        
3PBL_A           --------------------------------------------------------------------------------    
XP_001087197     --------------------------------------------------------------------------------     Rhesus monkey
EMC78343         --------------------------------------------------------------------------------     domestic pigeon
XP_002731088     --------------------------------------------------------------------------------     Saccoglossus ko...
CCD58583     384 tnklqptliltdaeclknyfepqiplptltqaytkvtsnnvnit------------------------------------ 427 Schistosoma man...
Q8IS44           --------------------------------------------------------------------------------     fruit fly
ABI64137         --------------------------------------------------------------------------------     California spin...
Q6RYS9       336 lddkyssailtsfqtsrsfgeeleeil----------------------------------------------------- 362 nematode
NP_001024048 353 svgtanstaqsvasasgmpaffaqnisttspsssscartttttsaipkasderefgnsstprssleslsenvnvitndfv 432 nematode
AFC88981         --------------------------------------------------------------------------------     southern cattle...
EFV59979     353 skptdfesttmevgsssetttlfts------------------------------------------------------- 377 Trichinella spi...

Feature 1                                                                                        
3PBL_A           --------------------------------------------------------------------------------    
XP_001087197     --------------------------------------------------------------------------------     Rhesus monkey
EMC78343         --------------------------------------------------------------------------------     domestic pigeon
XP_002731088     --------------------------------------------------------------------------------     Saccoglossus ko...
CCD58583         --------------------------------------------------------------------------------     Schistosoma man...
Q8IS44           --------------------------------------------------------------------------------     fruit fly
ABI64137         --------------------------------------------------------------------------------     California spin...
Q6RYS9           --------------------------------------------------------------------------------     nematode
NP_001024048 433 sencttfsrrssyaddsqptssqtssgdgrsysikgqkrfrnlsrnystkhhrkvvkvnrgnsrnnsrtasitnqsddal 512 nematode
AFC88981         --------------------------------------------------------------------------------     southern cattle...
EFV59979         --------------------------------------------------------------------------------     Trichinella spi...

Feature 1                                                                                        
3PBL_A           --------------------------------------------------------------------------------    
XP_001087197     --------------------------------------------------------------------------------     Rhesus monkey
EMC78343         --------------------------------------------------------------------------------     domestic pigeon
XP_002731088     --------------------------------------------------------------------------------     Saccoglossus ko...
CCD58583     428 ---------------------------------------------------------tttttittttitttttnnnnnip 450 Schistosoma man...
Q8IS44           --------------------------------------------------------------------------------     fruit fly
ABI64137         --------------------------------------------------------------------------------     California spin...
Q6RYS9       363 --------------------------------------------------------------------------pfidgs 368 nematode
NP_001024048 513 ipaiirtisrksprlfrrdktdikkhsmilanpiteppkeyrrvsmpihptnsqtetetisasrdienlptttisrstta 592 nematode
AFC88981         --------------------------------------------------------------------------------     southern cattle...
EFV59979     378 -----------------------------------------------------------------------------apt 380 Trichinella spi...

Feature 1                                                                                        
3PBL_A       310 -----------------------------------------------------------------naklkpvydsldavr 324
XP_001087197     --------------------------------------------------------------------------------     Rhesus monkey
EMC78343     303 -------------------------------------------------------------------------ikpaaps 309 domestic pigeon
XP_002731088     --------------------------------------------------------------------------------     Saccoglossus ko...
CCD58583     451 ssqpefknmddfrkhlknrikrakrsslsmlttnvfaglsskqvyalntntdvkksttyrfksslsskrqirrmkslipy 530 Schistosoma man...
Q8IS44       342 --------------------------------------------------------------------dkstefmlatvv 353 fruit fly
ABI64137     415 -----------------------------------------------ssegrgatpfvqsarngaaeavkgaeggnvgqp 447 California spin...
Q6RYS9       369 nsvkhsreqlhttrsntsttrlldvkpelrsisvpsiqdekklsqksndlpfshqngthkqkllpnpgilmksksttllk 448 nematode
NP_001024048 593 nsaellgspddfekfpalitetvledvlaetregcfmqptvsfaltvremegnalnnlkgcsvessrrvsqvdpplaiqi 672 nematode
AFC88981     404 ----------------------------------------aecdeeeasflaaqsatsgsdppshathnrnhdsgyvdsn 443 southern cattle...
EFV59979     381 spnlkllqadvcepkmqtsllvnnetaqqakrrnttcsveidhlppnnrapclkqycfpkrsqqqtnnfrlnfrwshsdi 460 Trichinella spi...

Feature 1                                                                                        
3PBL_A       325 raalinmvfqmgetgvagftnslrmlqqkrwdeaavnlaksrwynqtpnrakrvittfrtgtwdaygvpLREKKATQMVA 404
XP_001087197 282 ---pcgpdrappapglpqglrgpncappvpglppdscdsncappdavraaalppqtppqtrrrrrakitGRERKAMRVLP 358 Rhesus monkey
EMC78343     310 nhrlvvpiastqgtnstlqapldspgkaeknghaketpriakvfeiqsmpngklrtsllkamnrrklsqQKEKKATQMLA 389 domestic pigeon
XP_002731088 258 ---------------------------gqiqnntdgtggnatlqrpqnalgrqhsrstfpnvkpnkfsmRRERKATKTLA 310 Saccoglossus ko...
CCD58583     531 dtskshneqtneqlvkkpifkkrkslisrevkneqlnpkvnssnsimnmnyfltnnsgsninlkeslaaKREKKATKTLA 610 Schistosoma man...
Q8IS44       354 eetgnvamkplsfvrygvqeamtlarndstlsttsktssrkdkknsqasrftiykvhkaskkkrekssaKKERKATKTLA 433 fruit fly
ABI64137     448 easprqallvkqkkvklqskrngsanssratasesgellekkdkkassarftiykvnkaskkkrekssaKKERKATKTLA 527 California spin...
Q6RYS9       449 tngymdtdslnrnshkksladllandefsfsdsmrvyknrlfkslsratsgwnkprpsrhmvkkatkqmRREHKATVTLA 528 nematode
NP_001024048 673 ltrpslphldlqrmdsigttcssktradslrsvdskgskksnrngiavklvkraikhehslkrkvskaqRKEKRATKTLG 752 nematode
AFC88981     444 vdevhfsrqerpnkefkkngtvmplltvsvvggptlgasiedgparkksrfnlgrkhkssrkkrekasaKRERKATKTLA 523 southern cattle...
EFV59979     461 rcnvpnkideldkqaiakeiiraemrraelsrdkansttaqmpnqhpddqtkldnylirrvtmklskaeRNEKKATKTLS 540 Trichinella spi...

Feature 1                    ##  #                        #   #   #                     
3PBL_A       405 IVLGAFIVCWLPFFLTHVLNthcq---------tchvSPELYSATTWLGYVNSALNPVIYTTFNieFRKAF 466
XP_001087197 359 VVVGAFLLCWTPFFVVHITQalcp---------acsvPPRLVSAVTWLGYVNSALNPVIYTVFNaeFRNVF 420 Rhesus monkey
EMC78343     390 IVLGVFIICWLPFFITHILNmhcd----------cniPPAMYSAFTWLGYVNSAVNPIIYTTFNieFRKAF 450 domestic pigeon
XP_002731088 311 IVLGVFLICWIPFFTLNILFgvcp----------tctAPHTSSRALFLGYINSTMNPIIYTVFNneFRRAF 371 Saccoglossus kowalevskii
CCD58583     611 IVLGVFLFCWMPFFTNNIIQafcfkyqllqqsqlchmPDCITSICVWLGYVNSVLNPIIYTIFNveFRKAF 681 Schistosoma mansoni
Q8IS44       434 IVLGVFLFCWLPFFSCNIMDamcakf-----kkdcrpGLTAYMMTTWLGYINSFVNPVIYTIFNpeFRKAF 499 fruit fly
ABI64137     528 IVLGAFLVCWVPFFTCNIVNaiskktq----npslepGMAIFVLTTWIGYMNSFLNPVIYTIFNpeFRKAF 594 California spiny lobster
Q6RYS9       529 VVLAVFLFCWLPFFVLHLSNsicliid----ensacvGFLPLYLATWLGYLNSSLNPLIYTVFDqrFRNAF 595 nematode
NP_001024048 753 VVVGVFLVCWVPFFVINILNavcilln----kdscqvGYDLFFYCTWIGYMNSFMNPIIYTIFNteFRRAF 819 nematode
AFC88981     524 IVLGVFLICWVPFFTCNVVDavcmklq----sqdchlGVTVFLLTTWLGYVNSCVNPVIYTIFNpeFRKAF 590 southern cattle tick
EFV59979     541 IVLGIFLACWLPFFTLNMLNaicikle----naqcqvGFMPFFLTTWLGYMNSFMNPIIYTLFNieFRKAF 607 Trichinella spiralis

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