6JRP


Conserved Protein Domain Family
HMG-box_CIC-like
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cd21990: HMG-box_CIC-like 
Click on image for an interactive view with Cn3D
high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins
CIC is a transcriptional repressor which plays a role in the development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, CIC is involved in brain development.
Links
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Statistics
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PSSM-Id: 438806
Aligned: 22 rows
Threshold Bit Score: 144.137
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
DNA binding
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:6JRP; Homo sapiens protein capicua homolog binds DNA through its HMG-box domain, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ## ## ##   #  #          ###  ##     #                  #          #####    
6JRP_A          3 HIRRPXNAFXIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKK 80   human
Q9U1H0        489 KIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRK 566  fruit fly
RUS78207     1142 HIRRPMNAFMIFSKKHRALVHEQHPNQDNRTVSKILGEWWYALAPDQKQSYHDLAAKVKEAHFKAHPDWKWCSRDRKR 1219 eastern emerald...
KFM61567     1049 HIRRPMNAFMIFSKRHRSLVHQRHPNQDNRTVSKILGEWWYALEPERKQKYHDLAYEVKEAHFKAYPNWKWCSRDRKK 1126 Stegodyphus mim...
PIK59592      134 HVRRPMNAFMIFSKRHRSRVHQMHPNQDNRTVSKILGEWWYALKPNEKQEYHALAFQVKEAHYKAHPDWKWCSRERKK 211  Japanese sea cu...
ROT65174     1282 HIRRPMNAFMIFSKRHRPLVHQRYPNQDNRTVSKILGEWWYALGPEEKQKYHSLASEIKEHHYRAHPDWKWCSKDRRK 1359 Pacific white s...
NP_001076773   77 HVRRPMNAFMIFSKRHRPLVHQQYPNKDNRTVSKILGEWWYSLAADQKAEYHKLATQVKEAHFKAHPDWKWSTKEKKI 154  Caenorhabditis ...
CAD58844      175 HIRRPMNAFMIFSKMHRGLVHQRHPNQDNRTVSKILGEWWYALPSTEKQKYHNLAFQVKEAHFKAHPDWKWCSKERKR 252  vase tunicate
OAF67879      310 HIRRPMNAFMLFSKIHRPVVHQEQPELDNRGVSKVLGEWWYNIVAEKKEIYQNYATKLKEDHFRNNPDWKWCTKIKKM 387  Intoshia linei
CBY20236      240 HIRRPMNAFMLFSKFYRGEVHKMYPKQDNRSVSKILGEWWNTLNSDEKQRFINKANLMKEEHYKQHPDWKWSNKERKK 317  Oikopleura dioica

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