Conserved Protein Domain Family
DUF4527

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pfam15030: DUF4527 
Protein of unknown function (DUF4527)
This family of proteins is functionally uncharacterized. This family of proteins is found in vertebrates.
Statistics
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PSSM-Id: 464456
Aligned: 12 rows
Threshold Bit Score: 381.084
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023109094  109 GPQGTETDTPKEDLRLCIGHLQHQV-LTLRCQLRDQASAHRVLQVSHGEATRLRDQLKGELEELQ--------------- 172 
6_pfamImport    1 QPQHSETEAPEEDLRLRARRLHHQV-LTLQCQLRDQAAAHRELQVSRDQALHLQEELKGKLEELQ--------------- 64  
Q6ZRC1          1 MLRDSEAEVTEEDPRLRAQQLHHRV-LTLQCQLRDQGAAH---QASLDEATRLQEELQAKLEELQ--------------- 61   human
XP_023494148 1066 QLQDPEAETSEEALRLQVRQLHHQV-RTLRCQLRDQGSAHRGLQASLHEAVHLRAELTGQLEELQ--------------- 1129
4_pfamImport    1 QDADADAETPEDDLRLRVRRLRHQV-LTLQCQLRDQASAGRQLQAARDQALRRRDQLQGQVDELQ--------------- 64  
5_pfamImport    1 QLQGVEAEASEEGLRLRVGQLHHQA-LTLKCWLRDQGSLHRELQASREETGRLRKELQDQLTEFQ--------------- 64  
XP_007496815 1127 QLQDTKTMIPKRESKSNNKLLHHQI-LTLKSQLRDQAVLHSELQTSQNETRYLQGQLTEKIEELK--------------- 1190
XP_004770590  965 QLRDPEADPPTEDLRVRVGQLQHRV-LTLQCQLRDQTSAHRQLQEALGEAARLREQLQGQLDELQ--------------- 1028
XP_022272067    6 RLQDLEVDTPREDLRLQVQQLRHQG-LTLQCQLRDLTSAYR-------EATCLRDQLKSELHELR--------------- 62  
XP_027826566 1223 RLQDQEASASEEDLRLRVRRLHHQV-LTLQYQLRGPGSVHRELQASRGEAEHLKGKL----DELQ--------------- 1282 sheep
ELR50116        1 QLQDRKASASEEDLRRHIRRLHHQV-LTLQRQLRDQWSAHRELQASREEAEHLK----GKLDELQ--------------- 60   wild yak
XP_020956634  971 SEQEMGLAGEWTEPRLSLENSRRTAdSTAPSLVRGNAARCSALQGSSDRAGVKEAPKRP--WCPAdqgqaprsphsgfqh 1048 pig
XP_023109094  173 -------------------------------RKQHEANSAVAPLK------------AKLASLVQKC----RER-NRLIT 204 
6_pfamImport   65 -------------------------------KKQHEAHLAVTPLK------------AKIASLVQKC----RER-NGLIT 96  
Q6ZRC1         62 -------------------------------KKQHEAKLAVTPLK------------AKIASLVRKC----RER-NRLIT 93   human
XP_023494148 1130 -------------------------------KKQHEANLAVTPLK------------AKLASLVQKC----RER-NHVIT 1161
4_pfamImport   65 -------------------------------KKQHEAILAVTPLK------------AKLASLVQKC----RDR-NHLLT 96  
5_pfamImport   65 -------------------------------KRQHEASLAVTPLK------------AKVASLVQKC----LER-NNLIT 96  
XP_007496815 1191 -------------------------------RRKNEVNSAVTPLR------------AKVASLVQKC----RDR-NNLVA 1222
XP_004770590 1029 -------------------------------KKQHEANFAVAPLK------------AKLASLVQKC----RER-NHLIT 1060
XP_022272067   63 -------------------------------KKQQEANFAVAPLK------------AKLASLVQKC----RER-NHLIT 94  
XP_027826566 1283 -------------------------------KKHHEVNLAVTPLK------------AKLASLVHKC----WER-NHLIT 1314 sheep
ELR50116       61 -------------------------------KKHHEVNLAVTPLK-----------------AKLASlvqkCRErNHLIT 92   wild yak
XP_020956634 1049 rdpeaeaseedlglrvkqlchqvrtlqcqlrDQNSAHRALQASFEeatglqgelqgkAKLASLVQKC----RER-NHLIT 1123 pig
XP_023109094  205 HLLRELHRRGAEDPLLSETARGMVDDVALAEYAATFLAPALPETSHH--LDVESETAAAVRAQKYLPKPKTDSVViQRPL 282 
6_pfamImport   97 HLLQELYRHRPANLLLSELVQGMVNDVALAEYAATFLAPGVPETSYH--LDMESERTAVLRAQRYLLNPGGDSVL-QSSL 173 
Q6ZRC1         94 HLLQELHRHGLGNLLLSELAQNMLNDVALAEYTATFLAPGVPETSHH--LDVKSEMTAALRAQTYLLNPEMDSVL-QSSL 170  human
XP_023494148 1162 RLLRELHRHGALDRLLSETAQSMVNDAALAEYAATFLAPGVPQTGHH--LDAESEKTAAVRAQKCVLDPEIDSVL-QRPL 1238
4_pfamImport   97 RLLQELCRHGPADRLLCQTVRSMVDDVALAEYAATFLAAGVPELEFS--SEPRTEMTTGVAPQNSLLNPEVDSAL-SRPW 173 
5_pfamImport   97 HLLQELHQRGAASPLLAERTRSMVDDVALAEYAATFLTTGVREISHP--PGVRSEKADVVRAQRCSLNPEGESLL-PSPP 173 
XP_007496815 1223 QLLQELHRHGIENLKLSETARALVDDVAVATYASTFMSSEPREPCHQ--SDAMSEDIALGKDQTCLLSPDM-----ANPL 1295
XP_004770590 1061 HLLQELRRHGLEDQLLSEMAQTMVDDVALAEYAATFPASGLPETSHQ--PDVEPEKAAAVRAQKYHLNPKMDSVLtQRPL 1138
XP_022272067   95 HLLQELRRHGLANHLLSETAQSMVDDVALAEYAATFLAPGLPETSHH--LDVESEKAGVVGAQKSLLNLKTDSVSiQRPL 172 
XP_027826566 1315 HLLQELRRHGADNHLLSRMAQNMVNDVALAEYTATFLAPRVPETSHH--LDIESEMTAFVRVQKCLLNPQMDSVL-QRPL 1391 sheep
ELR50116       93 HLLQELRRRGAENHLLSGMAQNMVNDVALAEYAATFLAPRVPETShh--lDVESEMTAFVRVQKCLLNPQMDSVL-QRPL 169  wild yak
XP_020956634 1124 RLLEELHRHEGGNHLLSEMAHSMVTDVALAEYAATFLAPGDPETSCHldLDVESEQTADEKAQKYLLNPELDSVL-QRPL 1202 pig
XP_023109094  283 ---HSESWPVPEAE---WPAQnTARP-DSPKLPPPSGPTPGPGacPCPAAAAVEPACPARRPRGEGGLSCP-V-LRADDP 353 
6_pfamImport  174 ---CPESWPVSEAE---YPGQ-TAHV-DSLKLPLPLGLMRDPG--PCLEAVTVEPGPPAQQLHEEGGMPCP-D-PQAVGH 241 
Q6ZRC1        171 ---SSESWPIPEPE---WPAQ-TAQL-DSLKLPLSLVSTLDPG--TCLAAVTVEPGLPAQRLQEKGGMPCP-A-LQVDNV 238  human
XP_023494148 1239 ---CSESWPIPTAE---GPTQ-AAGP-NSLKLPLSSGPTPDAG----PRPISVRPGLPAQGLQEKDGMSCP-A-LPADGR 1304
4_pfamImport  174 ---RPEPWPVTEAE---WPAP-TARL-DALEPPRPPGPTPDPG--PRPAVATEASGLPAQRLQERGGVSCA-A-PQAAGP 241 
5_pfamImport  174 ---SSESRQASEAN---WPPW-TASLkDCIEIPVPPGLKQDPW--MNPAAGAEEPGFLAQHWQGTGGNPCP-A-LHTDGL 242 
XP_007496815 1296 gyfSSDTSPAADSDpllWKTH-TGSP------NLPSGVMNNPR--TCQTGMDVGVGLISESIQQETQEICSlStPPTNDL 1366
XP_004770590 1139 ---HSESWPVPKAE---WPAQ-TARL-HSLKLPLPSGWMPAPG--VCPAADPAEPALPSQSLKEEGGPSCP-V-PQADGL 1206
XP_022272067  173 ---HSESRPVPEAE---WPAQ-MARL-DSPKLPLPSGLTPAPG--ACPATATVETALSAQSWREEGGPSCP-IlLRADGL 241 
XP_027826566 1392 ---HSESWPILEAE---WPAW-TAQL-DYLKLPLPSGLMADPE--ICQASVTMEPGLPVQCLQEKxrTSCP-G-LXSDDL 1459 sheep
ELR50116      170 ---HSETWPIPEAE---WPAW-TAEL-DSLKLPLPSGLMADPE--ICQASVTMEPGLPVQCLQEKGGTSCP-G-LQSDDL 237  wild yak
XP_020956634 1203 ---HSESWPIPEAE---WP-Q-TAQL-DSLKLPWPSGPMPDPG--TGQASVAVEPGLPVQWLQEQGGRSRP-V-LQAAPL 1269 pig
XP_023109094  354 PPPSELLSPARILAFHKELTQSIRSNAQVHRSPLEL 389 
6_pfamImport  242 PAPAELLSPVRILAFHQELRQSICSHFQVNKSPLEL 277 
Q6ZRC1        239 PAPSELLSPARILAFHQELRQSICSNSQVHKSPLEL 274  human
XP_023494148 1305 PPCSELLSPARILAFHKELRESICSNSQVHKSPLEL 1340
4_pfamImport  242 LP-SELRSPARILAFHRELSRSVRGCPRVTESPLEL 276 
5_pfamImport  243 PPHSELRSPARILALHKELRQSICSNSRVNKSPLDL 278 
XP_007496815 1367 PLPSKVMSPERILALHWELSHSRYNNYQNLASPSES 1402
XP_004770590 1207 LPPSELLSPARILAFHKELRQSICSNSQVHKSPLEL 1242
XP_022272067  242 PPPPELLSPARILALHKELRQSICSNSQVNKSPLEL 277 
XP_027826566 1460 LPSPELLSPAQILALDQELQQSFSSTSQVNKSPLEL 1495 sheep
ELR50116      238 LPSPELLSPARILALHQELRRSFSSTSQVNKSPLEL 273  wild yak
XP_020956634 1270 PPCPALRSPARILALHQELRQSVCSSAQVHQSLLEL 1305 pig
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