Conserved Protein Domain Family
MATE_like_12

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cd13142: MATE_like_12 
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins
The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Statistics
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PSSM-Id: 240547
Aligned: 35 rows
Threshold Bit Score: 439.32
Created: 24-May-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O73981    23 RKEILEGPIEGTLFKLAWPIIINNLIQVLYNITDTFWLGKLGraALSAPGVSWPIIGTLMALGIGFTMAGFSIVGQYIGA 102 Pyrococcus horikoshii
ADI32113  13 RKRILKGDIVKTVLWLAWPIILANLVNMSYNLIDAYWLGKLGkeAFGAPTVSWPLIMLFYSIGFGFSRAGIALIAQYVGA 92  Staphylothermus hel...
AFH42339   6 KEEIFSENIGSTLIKLSIPLIVSDLVQVIYNFVDTFWLSRLGteALSAPVVSWPPVYFLISFGAGLLSSGIATISQDYGK 85  Fervidicoccus fonti...
AFH42458  10 PQEIQSGNVYKVLVKLGTPLALSEMVQVAYDLANLYWLGRVGkdAVAAPSASWPFTYTFIAAMNGLLASGTTLVSQYRGA 89  Fervidicoccus fonti...
ACL10528  12 RERILYGSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSeiAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGA 91  Desulfurococcus kam...
ADG90625   6 KQWVVKQPVLKTMLKLGLPIGVTQALQVVYNLTDMYWLGRLGreALAAVSATWPVLFLIIAGLAGLFQAGLALVSQYWGA 85  Thermosphaera aggre...
ADM27236   8 RDRIINGPIYRTLLWLGLPAVSVQLVNISYNIADAYWLSRYSpiDVAIPRQIWPSFMMFQALAMAIGAANQALISQYIGA 87  Ignisphaera aggrega...
ACB07396  10 REEIVNGPIVRTFFRLGIPPLINQLIAVAYNVLDALWLSIYNdlAVSVPRQVWPVIFLFNAPMQALTTVGMSTISQYIGM 89  Candidatus Korarcha...
O58340     8 REEILSGSIEKTLIRLAYPLIINNLVQVMYNLTDTFWLAKLGraELSAPGTVWPLLWFMISIGSGFAVAGFAMVSQYVGA 87  Pyrococcus horikoshii
ABM80154  13 ERVLSEENIVRLLVWLAVPLMASSSVRILYEAVDAFWLSRLGeaALGTPIVSWPYPDIVFAVAFGLSGSVSAIAGQYIGA 92  Hyperthermus butyli...
O73981   103 GNfEKANRSAGALFSLIIFFSTASAILS-ILILPYAls-fMHVTSSIRPYAYKYSLIIFAGVPMSFLFMTFNVLMRAIGD 180 Pyrococcus horikoshii
ADI32113  93 GNlKMANKSAGNLLSFMALISLSISGIGyFLSPPILs--lMGVPLDIYPYAVEYIRIIFIGVPIAFIGFAFNTIANSLGD 170 Staphylothermus hel...
AFH42339  86 GDyKSAREYSGVLFLFTLVFSLIVSVIPaIFSYYILk--iMNIPEDLIPFANIYLRTILLATPFAYIGITFTTITSALGD 163 Fervidicoccus fonti...
AFH42458  90 NNiNMMNKSVAQTFVLAIISSLIISVSG-ILTIPYIly-aAGIPSDVYPLSVVYSRIMFVALIFISLWESFRAVVSASGN 167 Fervidicoccus fonti...
ACL10528  92 RRyDEARKYVSFFVSATLLINSVVSIIY-FILRPMIfsyiVRTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGD 170 Desulfurococcus kam...
ADG90625  86 GDyRRSLNAGGQLLIIAIFTGIPLEVLS-YMVIPTFlr-lIRIPEEVAEGAIIYGRIFALGFAIFGLMESVLSIYSAAGD 163 Thermosphaera aggre...
ADM27236  88 KMyVNAIRTIKQYFTLSFILGAIMSITY-YLLRPLIflfiSSPPQEIVNGVLNYSAIISIDLFTSYFVLCFSIIIQSAGD 166 Ignisphaera aggrega...
ACB07396  90 KDyREAEISASKLLTMASSLGIFLSISL-FSLRSFIfsqvIGTPEEIAGWVMDYSAIMSVNILLNYIVFSYNTVLQAIGD 168 Candidatus Korarcha...
O58340    88 GEyKKASKVAGSLYSLLLALSTIIAFLG-ILISPLAlk-fIKVTPDVYPYALKYMKIVFGGIPIALTLYAFNFILRAVGD 165 Pyrococcus horikoshii
ABM80154  93 GLyDRASRSAGTVLGLIMIVAVPGSIAI-AATAPLYld-aIGVPETVKPLAEVYLAIIALGTPFSALFLFFNMLLGAAGD 170 Hyperthermus butyli...
O73981   181 TRTPVKISLITVFLNIILDPIFIFI---------LNLGVEGAALATVLSNSVGTVIGVRILTSGRAGLKIsr-enLKPDW 250 Pyrococcus horikoshii
ADI32113 171 TRTPTYINIVSSSTNMVLDPLFIFGyf-----gfPAMGVKGAAVATVLSRSIVSIIGSYLLFTGYRGIKIti-ndLGIEK 244 Staphylothermus hel...
AFH42339 164 VGLTMKINLLSVVINVILDPFMIFGiy-----pfPKMGVFGSALATLVSEVVVAIYSIFMLFYKYKKLNIgv-kdLKFDM 237 Fervidicoccus fonti...
AFH42458 168 TITPMKYNFFGVGLNMIFDPFLILGig-----pfPMLGVAGAGISTLISRAIVAFISLNNIIQGKSDVRLik-seMKIDK 241 Fervidicoccus fonti...
ACL10528 171 TRTPALINFGAASMNMVLDPIFILGvgingsmliPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPrl--tLKIES 248 Desulfurococcus kam...
ADG90625 164 TFTVMKIRLIGVTINIVLDPIMIFGlf-----gfPALGIAGAAIATLLSDLVSGVISLVLLSKRGVRGERltksdLKPDP 238 Thermosphaera aggre...
ADM27236 167 TRRPAIVNAISATINIILDPFLILGiy-----lfPRLGVIGAAIATVLARIVGAIILYIIMHRKFPFIEIgi--tTEIDR 239 Ignisphaera aggrega...
ACB07396 169 TKRPAIINAFAVSVNTVLDPFLVLGip-----pfPRTGVIGAALTDVLGSIISLVLLSSLLRKYELRMGF-----TSLGW 238 Candidatus Korarcha...
O58340   166 TKTPVKVNILTILLNIILDPVFIFG---------LNYGVLGAALATVISEGTGSVIGGYLLFTGRVSIKLsl-edLSPDI 235 Pyrococcus horikoshii
ABM80154 171 TRTPVKVSIAATAINAVLDPILIFV---------ADLGVLGAALATFIASLFSASYAAYSLATGRHGFRLgi-rdLIPDR 240 Hyperthermus butyli...
O73981   251 KFYSKIVRIGLPSSIGQSANSFGFVVLTRIIMGFGDVTYAAYVITtRLVNFITSISRGISMAMSTMVAQNIGAENyERAK 330 Pyrococcus horikoshii
ADI32113 245 WWIKKVVSIGTPLTIQQSSNSLGFTIMMSIVSRFGSVAVSAYGVAiRIIDVLSAFTWGINRALSIMVGQNLGAEYyDRTK 324 Staphylothermus hel...
AFH42339 238 KWLKEIFRIGVPLGIHRSSNSLAQTFSISLLSFYGADVIAAYGITtRIIDFVQSITTGYARATAIMVGANLGRKFiDRSK 317 Fervidicoccus fonti...
AFH42458 242 NILKMMVKIGTPLSVAWVMEALGFSILTAIISMEGSTALAAWGIGdRPLNLLNFATIGFINATGIMVGQSLGASNrKRAE 321 Fervidicoccus fonti...
ACL10528 249 DWLAKNLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGlIMMDLADATLWGFTSSIAVMVGQALGAGLiDRAR 328 Desulfurococcus kam...
ADG90625 239 FLIKKFFRIGLPISISSLSDAAGFTVLTSIISLMGAGALAAWGVGdRPFSLIDILVGSVLAALSTIIGQNLGAENfGKAI 318 Thermosphaera aggre...
ADM27236 240 EWLMTTFRIGIPILLQNIFNSLAFQIQLRLINSFGVATSVAWSIGfTVIDIANSVLWGLSQATAIMVGQNLGANNiDRSK 319 Ignisphaera aggrega...
ACB07396 239 DWIKLSIKIGFPVFIMASMNSLAFIAQLRLVNAFSIVAVTAYSIGfVVADIADAALFGLVSASSIMIGQNLGAGNlNRAK 318 Candidatus Korarcha...
O58340   236 KLYIKTFKIGLPASISESTNSFGFVLLNRIIYTYGTVAFATYTITnRLTNFMFAFADGISQAMGTMVGQNVGAEKyERAK 315 Pyrococcus horikoshii
ABM80154 241 SLLPLVAKVSAPLVVQRLGMTLGFMVMAGIVAGLGEVVLAAYQVGhVALSIDSIISMPLARSVGIVVAQSLGAGQtWRAR 320 Hyperthermus butyli...
O73981   331 VIAERTMVINFLIAGIAVLIIGIFRVPIFKVFL----NDPMVI-AESKIVLEYFLISVpFFNGIFVVVTGAFSSSGHTvk 405 Pyrococcus horikoshii
ADI32113 325 TIVKKTMWLTTIILVIGSVFIFLTRDLTVAFFV----PEKDVI-MEGSRVLAIFTWSI-PFFGLFFLGGAVAGGSGHTki 398 Staphylothermus hel...
AFH42339 318 EVVKKSLLDLSLILVFIGVILVLFRDQLIGIFT----QDPSVF-KYAVDYLFISSITL-PFYGWFFISYGVANGSGNTyf 391 Fervidicoccus fonti...
AFH42458 322 ESAEKSLMIISLIGVIGGLIFGAFGRHIASFFI----QDPDVI-EATIYYYIYMGSTI-VFFYYIQLMGAIAQGSGHTrf 395 Fervidicoccus fonti...
ACL10528 329 KVAFKSMLYIGVSTLIGSSIVYMLREAFISVFT----DNQVIL-SEADRFITVFLPSI-VFFALFFIGMSVGRGSGHTmv 402 Desulfurococcus kam...
ADG90625 319 EAAYKALALAIGMSSIGVFTMIALRYEVARLFIp---SDPEVI-QYASDFILIMGPSI-VFFTMLRVAFSVAQGSGHTkp 393 Thermosphaera aggre...
ADM27236 320 KIARYSQILIGSIIAIGSCFAYIIRHNIITLFIdpsdPEVNSIySETENFLKYALFTI-PFFGIFFVGSSVGRGSGHVli 398 Ignisphaera aggrega...
ACB07396 319 EISLKAAASVFSLLVLGILLVYPLRIGIVRAFT----EDASII-GETDKFLQYLLPTL-PFFGLFMIGMSAGRGSGRTlt 392 Candidatus Korarcha...
O58340   316 EIAIKAMLTNFLILIFGTMLFIIFREEIFRFFI----NDPGIL-KESEKVVKYFAASF-PFFGIFSAVTNVFASAGHTkk 389 Pyrococcus horikoshii
ABM80154 321 KAVKTGLLLLAGFVGAYIAAIVYFAEEFARIFT----SNPETV-KVIVDMLHVFGPSI-LSFNLLTLANVVARSSGHTff 394 Hyperthermus butyli...
O73981   406 SMIMSMLRLWGFRIPLSYVFGYvptfaklfGFTSRGVFFGMGLSNFLAAIVGLAWFLKGSWMR 468 Pyrococcus horikoshii
ADI32113 399 FAIISIIRLWVLRIGFSYLLALv------mGMGTIGIWVAMAISNIGAGLLALLWVFKGSWAR 455 Staphylothermus hellenicus DSM 12710
AFH42339 392 FGLLSVLRMWVFRILPMFICIYi------lTFNVIYIWLVIAVSNIISGITGLMWVNKKTWIV 448 Fervidicoccus fontis Kam940
AFH42458 396 VMVVSILRIWIIRNVLAYIFGPgp-----lNMGIPGIWIGMSLSNIISGLVALIWIFKADWKK 453 Fervidicoccus fontis Kam940
ACL10528 403 PTIMGIIRLWGIRILLGYILAFt------iGLGSLGVWISMSLSNVVAGLLMIIWVARGGWAI 459 Desulfurococcus kamchatkensis 1221n
ADG90625 394 VMYISILRLWFLRNILAYLFGPgp-----lSLGVKGLWAGMAVSNVITGLIALAWIVHGKWLK 451 Thermosphaera aggregans DSM 11486
ADM27236 399 PTIIDIIRLWIVRIALGYILSQ--------YLGSTGIWIAFALSNMFSGISATIWIQRGKWAK 453 Ignisphaera aggregans DSM 17230
ACB07396 393 PTIIGIFRLWVVRIGLGYFLSL--------SMGVMGIWISISLSNLLAGVAALIWLIYGNWNR 447 Candidatus Korarchaeum cryptofilum OPF8
O58340   390 NLTLGLIRLWGLRIPLSYYLGKt-------LKDSAGVWIGMGLSNVIAALVGFLWFLKGSWMR 445 Pyrococcus horikoshii
ABM80154 395 ISALGIARLWFLRIPLSWLLAYq------lGLGEKGLWAGMAISNHVAGGTALAWLAYGNWAK 451 Hyperthermus butylicus DSM 5456
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