2BPF


Conserved Protein Domain Family
POLXc

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smart00483: POLXc 
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DNA polymerase X family
includes vertebrate polymerase beta and terminal deoxynucleotidyltransferases
Statistics
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PSSM-Id: 214688
Aligned: 13 rows
Threshold Bit Score: 291.963
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2BPF_A        10 TLN-GGITDMLVELANFEKn-VSQAIHKY------NAYRKAASVIAKYPHKIKSGAEAK-KL----------PGVGTKIA 70  Norway rat
Q9YVX5       287 ILNkRKIIYMLHNIANIYEk-LDENKYKAynkainSIYEQGIIILKYNNTTINSPKLVD-NMetviskykdiPNIGDSIS 364 Melanoplus sang...
NP_001028151 165 NHN-QRFTDAFEILAKNYE--FKENDDTC------LTFMRAISVLKCLPFEVVSLKDTE-GL----------PWIGDEVK 224 gray short-tail...
NP_803461    174 NYN-HIFTDAFEILAENSE--FKENEVSY------VTFMRAASVLKSLPFTIISMKDTE-GI----------PCLGDKVK 233 cattle
O57486       159 NKN-TLFTDAFEILAENYE--FRENERSC------LSFRQAASVLKSLTFTIAGMADVD-GL----------PGFGDHIR 218 axolotl
NP_001079251 159 DTN-RIFTDAFDILAEHFE--FCENKGRT------VAFLRASSLIKSLPFPITAMKELE-GL----------PWLGDQMK 218 African clawed ...
NP_990720    163 NCN-KKFTDAFEIMAENYE--FKENEIFC------LEFLRAASVLKSLPFPVTRMKDIQ-GL----------PCMGDRVR 222 chicken
NP_001118178 154 hnN-KIFTDVMEELAESSE--FNESKGPC------LAFRQAASVLKSLPSAVHCLKAIQ-GL----------PCLGEHTK 213 rainbow trout
Q23687         9 RGHrENIIRIFQEMADLNNa-LGEKYKVS------SYLRSIESLKTNLDKPLNTPQDLK-AF----------SGFGAKLL 70  Crithidia fasci...
NP_592977    177 CVN-QAFVNALSVLKTCREv-NGESVRTR------AYGM-AIATIKAFPLPIDSAEQLE-KM----------PGCGPKIV 236 Schizosaccharom...
AAD39573     246 NIY-RGTISGVCILDYSLIvtLGEDRRSF------SYY-KAIPVIEKFPTRIESVDQLK-HL----------PGIGKAMR 306 thale cress
EDN62133     186 knN-ELIIGALKRLTKKYEi-EGEKFRAR------SYRLAKQS-MENCDFNVRSGEEAHtKL----------RNIGPSIA 246 Saccharomyces c...
BAI86366       1 MHK-KDIIRLLETIAVYMEl-KGDNPFKV------SAFRKAAAALEQDDRSLSEMDDMM-SL----------SGIGKGTY 61  Bacillus subtil...
2BPF_A        71 EKIDEFLATGKLrklEKIRQDDT--SSSINFLTRVTGIG-PSAARKLVD-EGIKTLEDL-RKN-E--DKLNHHQ-RIGL- 140 Norway rat
Q9YVX5       365 KKIYNIISNTYI---DNISNTKE--YKYITELMNVLYIG-PKTAKNLIS-KGIKTIKDL-KKNkD--KYLNSQQ-QIAI- 432 Melanoplus sang...
NP_001028151 225 GIMEEIIEDGESlevQAVLNDER--YQSFKLFTSVFGVG-LKTADKWYR-MGFRTLNKI-RSDkT--LKLTKMQ-KAGL- 295 gray short-tail...
NP_803461    234 CIIEEIIEDGESsevKAVLNDER--YQSFKLFTSVFGVG-LKTSEKWFR-MGFRSLSKI-MSDkT--LKFTKMQ-KAGF- 304 cattle
O57486       219 AVIEDLIEDGESskvSEVLNDEV--YRSLKLFTTIFGVG-LRTAEKWHR-LGIRTLEEI-KSNeN--LKFSKMQ-IAGL- 289 axolotl
NP_001079251 219 GIIEEILEEGKSykvLEVMNEER--YKSFKQFTSVFGVG-LKTSDKWFR-MGFRTLEEI-KNEkE--LKLTKMQ-KCGL- 289 African clawed ...
NP_990720    223 DVIEEIIEEGESsraKDVLNDER--YKSFKEFTSVFGVG-VKTSEKWFR-MGLRTVEEV-KADkT--LKLSKMQ-RAGF- 293 chicken
NP_001118178 214 AVMEEILTFGRSfkvEEIRCDER--YQALKLFTSVFGVG-PKTAEKWYR-RGLRSLQEI-LTEpN--IQLNRMQ-RAGF- 284 rainbow trout
Q23687        71 KKAEEIMATGKLe-eLESKTKPK--LKAIQELTQVHGFGpRAAAALFDR-EGIFTVEEL-LQKaDsiSSLTDQQ-RVGI- 143 Crithidia fasci...
NP_592977    237 HLWKEFASTGTLkeaEEFQKDPA--SKILLLFYNIFGVG-ASHAAEWYQ-KGWRTIEQV-RKHkD---SFTKQI-KVGL- 306 Schizosaccharom...
AAD39573     307 DHIQEIVTTGKLsklEHFETDEK--VRTISLFGEVWGVG-PATALKLYE-KGHRTLEDL-KN--E--DSLTHAQ-KLGL- 375 thale cress
EDN62133     247 KKIQVILDTGv----LPGLNDSVglEDKLKYFKNCYGIG-SEIAKRWNL-LNFESFCVAaKKDpE--EFVSDWTiLFGW- 317 Saccharomyces c...
BAI86366      62 SVIKEYIDEGKSs-tLESLQKEV--PEGLVPLLKLPGLG-GKKIAKLYKeLGVHDAESL-KEAcE---QQKVQG-LAGFg 132 Bacillus subtil...
2BPF_A       141 -----KYFEDFeKRIPREE-M-LQMQDIVLNEVKKLDpeYIAtv-------cGSFRRGAESSGDMDVLLthpnft----- 201 Norway rat
Q9YVX5       433 -----EYYDKL-KPINRSF-I-SNLESSIKLSPNKEW--YIL----------GSYARGKLTSKDIDILIv---------- 482 Melanoplus sang...
NP_001028151 296 -----CYYEDLiDCVSKAE-A-DAVSLLVQDAVWTFLpdALVti-------tGGFRRGKEFGHDVDFLItspgaekeqed 361 gray short-tail...
NP_803461    305 -----LYYEDLvSCVTRAE-A-EAVGVLVKEAVWAFLpdAFVtm-------tGGFRRGKKIGHDVDFLItspgsaede-e 369 cattle
O57486       290 -----QHYEDIlGGVRKAE-A-DAVAMVVRDAVWTFLpdAVVtl-------tGGFRRGNKTGHDVDMLItspiqgke--k 353 axolotl
NP_001079251 290 -----LYYEDItSYVSRAE-A-ETTEQLIKSIVWKFVpdAIVtl-------tGGFRRGKKKGHDVDILItcarkgke--k 353 African clawed ...
NP_990720    294 -----LYYEDLvSCVSKAE-A-DAVSSIVKNTVCTFLpdALVti-------tGGFRRGKKIGHDIDFLItspgqre---- 355 chicken
NP_001118178 285 -----LYYSDIsKAVSKAE-A-KAVGCIIEDTFHWIApdAILal-------tGGFRRGKEYGHDVDFLLtmpeigkd--e 348 rainbow trout
Q23687       144 -----KYFYDInEKIPMQEsV-LHENYLREKCLEVLGkdYTIai-------cGSYRRRHPFSGDVDALLsrthdap---- 206 Crithidia fasci...
NP_592977    307 -----EFYEDFcKTVTIEE-AtEIYETIVSRMPDGIKiqScl---------vGGFRRGKPVGADVDMVLspshth----- 366 Schizosaccharom...
AAD39573     376 -----KYFDDIkTRIPRQE-V----------RFLNFNvnFVClyypscn------------------------------- 408 thale cress
EDN62133     318 -----SYYDDWlCKMSRNE-C-FTHLKKVQKALRGIDpeCQVel-------qGSYNRGYSKCGDIDLLFfkpfcndttel 383 Saccharomyces c...
BAI86366     133 kkseeKILQALgEAGKQPE-R-FPIGY-ALRIAREIEehLSQfthiikfsraGSLRRARETVKDLDYIIatdhpa----- 204 Bacillus subtil...
2BPF_A       202 --sesskQPKl---------------L-HRVVEQLQKVRFITDTLSKG------------Etk---fmGVCQLPSENDEN 248 Norway rat
Q9YVX5       483 -------DFD----------------I-DEILKEIYKYAKEEAVLRHG------------K-------IMYSGIFKKDKT 519 Melanoplus sang...
NP_001028151 362 qllqkvtNLWkkqgll-----lycdlI-ESTFEDLKLPSRKIDALDHF------------Qkc---flILKLYHHKEDKR 420 gray short-tail...
NP_803461    370 qllpkviNLWekkgll-----lyydlV-ESTFEKFKLPSRQVDTLDHF------------Qkc---flILKLHHQRVDSS 428 cattle
O57486       354 ellhkviNLWkkqdll-----lchtiH-ESTMDEDNLPSKSVNLLDHF------------Qkc---faILKSNQHRGEIS 412 axolotl
NP_001079251 354 nilhntmSVLknrgll-----lfyniI-ESTFDETKLPSRHVDALDHF------------Qkc---ftILKLPKRQMDIG 412 African clawed ...
NP_990720    356 ddellhkGLLlyc-----------diI-ESTFVKEQIPSRHVDAMDHF------------Qkc---faILKLYQPRVDNS 408 chicken
NP_001118178 349 glllhviDRLkdqgil-----lycdyQ-GSTFDVSKLPSCRFEDMDCF------------Qkc---flILRLEQGQVEGE 407 rainbow trout
Q23687       207 plsepvaATGv---------------L-GNYVEHLEKTNYLEATMAQG------------Plk---ymGMGRLPPRIVRD 255 Crithidia fasci...
NP_592977    367 -stkhlvDVL----------------L-RILDEEFQFRLISVQEHSCG------------Gkkg--yvMLAVILSNSSKI 414 Schizosaccharom...
AAD39573     409 -flliflHFLy---------------CrCKRWNNFYRESARKLCLARG------------KatcgdldIVVTHPDGQRKE 460 thale cress
EDN62133     384 akimetlCIKlykdgyihcflqltpnL-EKLFLKRIVERFRTAKIVGYgerkrwysseiiKkf---fmGVKLSPRELEEL 459 Saccharomyces c...
BAI86366     205 ----------------------------evreqlLELPNIK-SVIASG------------Dtk----vSVILSFEYe--- 236 Bacillus subtil...
2BPF_A       249 Eyp-----------------------------------hRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKgfTI 293 Norway rat
Q9YVX5       520 Y--------------------------------------FLIDIYKTTESEKYTSIQYFTGSKEFNIALRSLALSK--DI 559 Melanoplus sang...
NP_001028151 421 Kwemptgsne---------------------seakswkaIRVDLVVCPYDRYAFALLGWSGSRQFERDLRRYATHEk-KM 478 gray short-tail...
NP_803461    429 Ksnqqeg---------------------------ktwkaIRVDLVMCPYENRAFALLGWTGSRQFERDIRRYATHEr-KM 480 cattle
O57486       413 Scdgphdsre---------------------rgkriwkaIRVDLVFCPFEQYAFALLGWTGSRQFERDLRRYASHEk-KM 470 axolotl
NP_001079251 413 Niidphec------------------------erknwkaVRLDLVITPYEQYPYALLGWTGSRQFERDLRRYATHEk-RM 467 African clawed ...
NP_990720    409 Synmskkcdm---------------------aevkdwkaIRVDLVITPFEQYAYALLGWTGSRQFGRDLRRYATHEr-KM 466 chicken
NP_001118178 408 Rglqrdpg------------------------dsrgwraVRVDLVAPPVDRYAFALLGWTGSR-FGRDLRTFAQKEr-QM 461 rainbow trout
Q23687       256 Kagrent---------------------------kvykaRRVDIRLIETKSVPTAMLTFTGSKNFNVIMRQAAIAKgyLL 308 Crithidia fasci...
NP_592977    415 N--------------------------------------RRVDIIVVPPAYIGSAVLGWSGGIFFLRDLKLYANSHl-GL 455 Schizosaccharom...
AAD39573     461 Lsglvk----------------------------dkkdnTMID-SAMSRDIYSFGLIAWTGNDVLNRRLRLLAESKgyRL 511 thale cress
EDN62133     460 KemkndegtllieeeeeeetklkpidqymslnakdgnycRRLDFFCCKWDELGAGRIHYTGSKEYNRWIRILAAQKgfKL 539 Saccharomyces c...
BAI86366     237 ---------------------------------------TSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERgeRI 277 Bacillus subtil...
2BPF_A       294 NEYTIRPLGVTGv--------aG----------------------------EPLPVDSEQDIFDYIQWRYREPKDRS 334 Norway rat
Q9YVX5       560 RLNQHEMYDLQT----------Q----------------------------KKYNIKSEKDIFDILGVKYVPPSKRD 598 Melanoplus sanguin...
NP_001028151 479 MLDNHALYDKTK----------K----------------------------IFLKAKSEEEIFAHLGLEYIQPSERN 517 gray short-tailed ...
NP_803461    481 MLDNHALYDKTK----------R----------------------------VFLKAESEEEIFAHLGLDYIEPWERN 519 cattle
O57486       471 MIDNHALYDKTK----------R----------------------------VFVKCESEEEIFGHLGLEYIDPVERN 509 axolotl
NP_001079251 468 MLDNHGLYDKTK----------N----------------------------NFLKANNEEDIFKQLGLDYLEPWERN 506 African clawed frog
NP_990720    467 MLDNHALYDKRK----------R----------------------------VFLKAGSEEEIFAHLGLDYVEPWERN 505 chicken
NP_001118178 462 LLDNHALYDKTK----------K----------------------------LCLLATTEEDIFTHLGLEYVEPWQRN 500 rainbow trout
Q23687       309 NEYGLFRLGTPE----------EaralyervgikgknageelgvpkeeledKRVDVRSEQDVFDALGMPYAKPENRD 375 Crithidia fasciculata
NP_592977    456 SYDSFEIINLKTgkdicpdefnE----------------------------WKDPVEAEKDIFRYFSLEYIEPKFRN 504 Schizosaccharomyce...
AAD39573     512 DDTGLFPATHSS----------Sgnrg--------------------argtASLKLSTEKQVFDFLGFPWLEPHERN 558 thale cress
EDN62133     540 TQHGLFRNN------------------------------------------ILLESFNERRIFELLNLKYAEPEHRN 574 Saccharomyces cere...
BAI86366     278 SEYGVETVETGE----------I----------------------------K--TFPSEREFYAHFGLPLIPPEIRE 314 Bacillus subtilis ...
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