3DCM


Conserved Protein Domain Family
Methyltrn_RNA_4

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pfam09936: Methyltrn_RNA_4 
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SAM-dependent RNA methyltransferase
This family has a Rossmanoid fold, with a deep trefoil knot in its C-terminal region. It has structural similarity to RNA methyltransferases, and is likely to function as an S-adenosyl-L-methionine (SAM)-dependent RNA 2'-O methyltransferase.
Statistics
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PSSM-Id: 430940
Aligned: 79 rows
Threshold Bit Score: 239.289
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3DCM_X            5 VYVALIHYPIKGKDGSIISTAVTNLDVHDIARTARTYNLKGYYIVTNLRAQQDMVSKMLKFWregfGSRYNPSRAESLKL 84  Thermotoga m...
jgi:Selin_2570  253 VSIALIHYPVYNKRHEVITTSVTNMDLHDISRTVRTFELTNYFVVTPVKSQHELMGRITRHWtegyGSTYNPDRKEAFDR 332
WP_013452113    249 IYVALMHYPMRDKEGKVVTTSITNMDLHDISRSCRTFGVKNYFVVNPMPAQREIASRVVRHWikgyGATYNENRKEAFEY 328 Calditerrivi...
jgi:Dacet_2278  246 IYVALLHYPMKDKEKENVATSITNMDLHDISRSCTTYDVKKYYVVTPLKAQREIAGRVIKHWlegyGATYNVNRKQAFEG 325
jgi:Flexsi_1962 249 LYVALMHYPMLDKQGDTVSTAITNMDLHDISRSCKTFGVKKYFVVTPLEAQREIAGRVLKHWqvgyGSAYNGNRKEAFSG 328
BAI79759        242 LYVGLMHYPMYDKEKNIVATAITNMDLHDISRSCKTFGVRNYYVINPLPAQREIANRVLKHWregyGATYNENRKEAFGV 321
CBW26714          4 LYLALVHHPIKNKRGDTVTTSVTNLDIHDIARSCKTFGVKKYFIVTPLKAQHDLVKKILGHWeddkNGVYNPDRQNALSI 83 
WP_014807375    233 VYVMLVHHPVLNKDGKTVTSAVTGLDLHDISRSCMTYGINKFIVVTPLKSQQEMVCKIVNHWekapEG-LNPMRSEALSL 311 Acetomicrobi...
WP_013047957    236 VYLALVHHPVMDHYGQKTTAALTGLDLSDISRSCRTYGLRKFLVVTPLKSQRELAKTMAAHWvkgyGASFNPSRAEAFKT 315 Aminobacteri...
Q6ML98           11 LAIGLVHYPVRDSKQKTVATNITNFDIHDIARAATVFGVEKYYIIHPMKEQLMFVDRVLDHWrtgqGSKFNPMRKTALGN 90  Bdellovibrio...
3DCM_X           85 VKLKSYLEDVLEDIESVEGERPLIFFTSAK--KRENDISFEEGRRIIi-eTEKPVLILLGTGWGLPDEILEISDYVLEPI 161 Thermotoga m...
jgi:Selin_2570  333 MQFVHSLEDVREHFRKR-GQRLVITATSAN--PKWTNTTYPHLSRMMdqdRETQHLILFGTGWGLTDEIMEAADYVLPPI 409
WP_013452113    329 TIITDSLASVIKSIEEKESGSPIIIATTAR--YQQKAISIEKLKEIA----DRPILLLFGTGWGFVDDILEFADYVLKPI 402 Calditerrivi...
jgi:Dacet_2278  326 TQLTEGLLDVIADIEKKEGERPVVVATTAR--DSRADIGFDEVSALS---EDKPCLIIFGTGWGFTEDVFKMSDRVLKPI 400
jgi:Flexsi_1962 329 TVIKSSLVETISDIEDAEGEKPLLVATSAK--RHKKTVAYKKIAEMA---AKKPVLLLFGTGWGFVPDIMEEVDYTAEPI 403
BAI79759        322 TKVKESLIEVIDEIEKAEGEKPLLVGTTAR--KRDDAVSFDELKKLT---FEKPVLLLFGTGWGFSDDMLEVCDYILERI 396
CBW26714         84 ATLVDSVEDALASIEEKEGKKPLLAVTGAN--FESFHGTTNDLKDLMg-sNDRPCLLLFGTGWGLHQSVLEKSDFMLDPI 160
WP_014807375    312 LKAFDSIEDCLAWIEKKEKKKPLTVATTAK--KRAGALPVFELKRILl-eRDLPVCILFGTSWGLADEVFSGVDVVLSPI 388 Acetomicrobi...
WP_013047957    316 MKTVPTLDKAIEWIKSKEHEEPLVVGTTAR--ACSGAIHWLEMKRTLl-eSQKPVLFVFGTASGLHKEVTERCSVLLQPL 392 Aminobacteri...
Q6ML98           91 VKAVESVEKAFEDWNVPE---ALTIATTARteWAKHKYSFAELRNEMh-vAKKPVFMLFGTGFGLTEDLIRSSSGVLESI 166 Bdellovibrio...
3DCM_X          162 RAQ-SD--FNHLSVRAAAAIIIDRLIG 185 Thermotoga maritima
jgi:Selin_2570  410 DGN-GE--YNHLSVRSAAAITLDRVFR 433
WP_013452113    403 HGV-GD--FNHLSVRSAVAIYLDRINr 426 Calditerrivibrio nitroreducens
jgi:Dacet_2278  401 EGA-GN--FNHLSVRSAVAIILDRIYr 424
jgi:Flexsi_1962 404 EGA-GD--FNHLSVRSAVAIILDRVVk 427
BAI79759        397 KGY-DE--FNHLSVRSAVAIILDRLni 420
CBW26714        161 LGA-DEsgYNHLSVRSAVAIYLDRYTq 186
WP_014807375    389 LGGkGD--YNHLSVRSAVAILLDRLFG 413 Acetomicrobium mobile
WP_013047957    393 SGGkED--YNHLSVRTAVGVILDRFFG 417 Aminobacterium colombiense
Q6ML98          167 RGA-PPkdYRHLSVRSAVSICLDRVMG 192 Bdellovibrio bacteriovorus
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