5UAZ


Conserved Protein Domain Family
Nup35_RRM
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pfam05172: Nup35_RRM 
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Nup53/35/40-type RNA recognition motif
Members of this family belong to the nucleor pore complex, NPC, the only gateway between the nucleus and the cytoplasm. The NPC consists of several subcomplexes each one of which is made up of multiple copies of several individual Nup, Nic or Sec protein subunits. In yeast, this Nup or nucleoporin subunit is numbered Nup53, Nup40 in Schizo. pombe and in vertebrates as Nup35. This subunit forms part of the inner ring within the membrane and interacts directly with Nup-Ndc1, considered to be an anchor for the NPC in the pore membrane. This region of the Nup is the RNA-recognition region.
Links
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Statistics
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PSSM-Id: 398713
Aligned: 7 rows
Threshold Bit Score: 100.934
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5UAZ_A   1 SMNwddhaIIIFGYPETIANSIILHFANFGEILEDfrvikdfkklnsk------------------------nmskspsl 56  Saccharomyces cerevis...
Q09601 198 DTW-----VTVFGFQPSQVSILLNLFSRHGEVVSH--------------------------------------------- 227 Caenorhabditis elegans
O13838 169 NTS-----VIVFGFPPELTNQVIAEFSRFGTIISEnsltass-------------------------------------a 206 Schizosaccharomyces p...
Q05166 263 SKSsslsaIIVFGYPESISNELIEHFSHFGHIMEDfqvlrlgrginpntfrifhnhdtgcdendstvnksitlkgrnnes 342 Saccharomyces cerevis...
O13026 166 DTW-----VTVFGFPQASASYILLQFAQYGNIIKHv-------------------------------------------- 196 African clawed frog
O04326 186 EEW-----VTVYGFSPGDTNLVLREFEKCGMVLKHv-------------------------------------------- 216 thale cress
Q9VWS2 190 DFW-----VTIFGFPPGAGSMVLQHFTVCGTIVDVv-------------------------------------------- 220 fruit fly

5UAZ_A  57 taqkyPIYTGDGWVKLTYKSELSKSRALQENGIIMNGTLIGCVSYSpaALKQLAS 111 Saccharomyces cerevisiae S288C
Q09601 228 -----QTPSKGNFIHMRYSCVTHAQQAISRNGTLLDQDTFIGVVQC--TNKDVIN 275 Caenorhabditis elegans
O13838 207 gftpsKGPISGNWLQLTYAEPSSAAKAVLSNGMLINDSFMVGCIYSpaEAKEHVP 261 Schizosaccharomyces pombe 972h-
Q05166 343 nnkkyPIFTGESWVKLTYNSPSSALRALQENGTIFRGSLIGCIPYSknAVEQLAG 397 Saccharomyces cerevisiae S288C
O13026 197 ------MSNNGNWMHIQYQSKLQARKALSKDGRIFGESIMIGVKPC--IDKSVME 243 African clawed frog
O04326 217 -----PGPRNANWMHILYQNRSDAHKALNKAGMMINGVVIVGVKPVdpIQKQALN 266 thale cress
Q9VWS2 221 -----HAPQNGNWMYVRYSSRIESDKALNYNEKIIAGNVMVGVSRC--TDRSVID 268 fruit fly
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