Conserved Protein Domain Family
PPP4R2

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pfam09184: PPP4R2 
PPP4R2
PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.
Statistics
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PSSM-Id: 462710
Aligned: 24 rows
Threshold Bit Score: 151.412
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCD26948       7 LNSSIHNMMGIKSRRLYEYLNDILITKKVKLSNSSNepiPFDLLINdFIPHMIDVTPN----------ESFInsneenie 76 
KRF93925      14 LERFTQLKQKEIPKELEDYLQYVAKTGDTVFKWSSLkylFREKLLS-VIKHFNEDPPRleeipnypnvDPFN-------- 84 
Q9W2U4        14 LERFTDLKQKEIPKELEEYLQYVAKTGDTIFKWSSLkylFREKLLS-VIKHFNEDSPRleeipnypnvDPFN-------- 84  fruit fly
EKC35391      11 LNDFEKKK-GEIPPVLEQYLKTIAKTGETLFPWPRVkplFVGKLEN-VMSKFNRELPAdhlap-cpnvENPK-------- 79 
Q6P964        10 FRDFEKKGEKESCPILDQFLSHVAKTGETMIQWSQFksyFLFKLEK-VMDDFKASCPEqrgpa-npnvEYIP-------- 79  zebrafish
A1L1M4        10 LKDFDKKVKKEASTVLDQFLCHIAKTGETLVSWSQFktyFVFKLEK-VMEDFHASAPEqrgpa-npnvESIP-------- 79  zebrafish
XP_005814738  10 LRDFDKKAKKEPIPLLEQFLCHVAKTGQTMVPWSQFknyFLFKLEN-VMDDFKASTPEqrasa-npnvESVP-------- 79 
Q5ZMU6        10 LKDFEKRGKKEVCPILDQFLCHVAKTGETMVQWSQFkgyFIFKLEK-VMDDFRTSAPEprgpp-npnvEYIP-------- 79  chicken
XP_014331120  10 FQDFEKRGKKETCPALEQFLCHVAKTGQPMIPWLQFktyFLFKLDK-VMEDFHASAPEerdsh-npnvEYIP-------- 79 
XP_003439001  10 FQDFEKKGKKETCPLLEQFLCHIAKTGQPMIPWSQFktyFMFKLEK-VMDDFHAATPEqrgph-npnvEFVP-------- 79 
CCD26948      77 sirrLKEMGENLIDKFFNNEKLPFTIMRIFELCFDPFKYFKvnELVKYVNALEKCCYVDSCLtlasSSSsSTNteerRDE 156
KRF93925      85 ----FETMKASLLERLDLFNAAPFTVQRLCELLIEPRKQYS--RIDKYMRALEKNILVVSTIdpgrKRT-DSD------N 151
Q9W2U4        85 ----YETMKSSLLERLDLFNAAPFTVQRLCELLIDPRKQYS--RIDKFMRALEKNILVVSTIdpgrKRT-ESE------N 151 fruit fly
EKC35391      80 ----FKEMRKRILDSLNKFSDAPFTIQRLCELLTDPKKHYR--RTDKFLRGVEKNMLVVSTVdpfgNKI-VSEsrevMVN 152
Q6P964        80 ----FEEMKQRILKIVNGYNGIPFTIQRLCELLTEPKRNYA--GTDKFLRGVEKNVMVVSCVyptsEK-----------K 142 zebrafish
A1L1M4        80 ----FEEMKERILKIVNEYNGIPFTIQRLCELLTEPKRNYT--GTEKFLRGVEKNVMVVSCIyptsEK-----------N 142 zebrafish
XP_005814738  80 ----FEDMKERILKIVKGYNGIPFTIQRLCELLTEPKRNYT--GTDKFLRGVEKNVLVVSCVhptsEK-----------N 142
Q5ZMU6        80 ----FEEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYT--GTDKFLRGVEKNVMVVSCVypssEK-----------N 142 chicken
XP_014331120  80 ----FEEMKNRILKIVDGYNGIPFTIQRLCELLTDPKRNYS--GTDKFLRGLEKNVMVVSYLhptsEK-----------N 142
XP_003439001  80 ----FEEMKTRILKIVDGYNGIPFTIQRLCELLMDPKRNYT--GTDKFLRGLEKNVMVVSCIyptsEK-----------N 142
CCD26948     157 EESNGNTIGEd-------------------------------gDASLVKIPWITEKDMGQLLPIVKEIDVIMNVEFDDDD 205
KRF93925     152 GDSLDSVGNGdislevnidiemenenifnngddrnvpieetncIAMKASCPRSDDSAAAPPKAKKAKLDFD------ENE 225
Q9W2U4       152 GDSLDSVVNGdlsmevnidiemennn--gnadegsspgagsagCAQKASCPRSDDND--QPKAKKAKLEID------GEE 221 fruit fly
EKC35391     153 GMEG-SPVNGnea---------------------------dssPTTTPNIGPSLYPGAIPLQQTNWTTDSWAGVGTSQEA 204
Q6P964       143 GSSCVNRMNGvmfpgntsafpd---------rnvngpgtprplNRPKHSLSSNVATNGLPDSTESKEQ---------ASE 204 zebrafish
A1L1M4       143 GCSGVNRMNGvmlsgntsafte---------rkvngpgtprplNRQKHSMSSSLATNGLPDSTENKDTN--------TPQ 205 zebrafish
XP_005814738 143 GCSTVNRMNGvmlpgnasafie---------rkvngpgtprplNRPKVSLVNSLAANGLPDSTDNKDLN--------TEQ 205
Q5ZMU6       143 NSSSLNRMNGvmfpgnspgyser--------snvngpgtprpvNRPKVSLSTPMTTNGLPDSTEHKESS--------LQQ 206 chicken
XP_014331120 143 GTSTMNRMNGvmflgnpslyses-------srnvngpslsktlNRPKLS-SSSLSTNGLPECPASKEPDG-------ITE 207
XP_003439001 143 GASSINRMNGvmfpgnsslytd---------rnvngpgtpkplNRPKLSLPTSLSTNGLPDCPVSKEPEPA------TEE 207
CCD26948     206 EDDDEEDDeehhdvngqgtirerkSNKhGGTSTDDISITLQNDKDFIIEEyyeddddddddmnvedtnknlTNTPDDEEE 285
KRF93925     226 QRD-EEd---------------------AEEADEEVATMNSKSKADKAKA--------------------------ETAD 257
Q9W2U4       222 RSEASDe---------------------TD----TEVATRVK----------------------------------NEKD 242 fruit fly
EKC35391     205 ARDTTCNEdppp--------gagaPATdSTPHVSVKEEEKEAPPDSNLET---------------------TDGDQAPSE 255
Q6P964       205 QSERTVn---------------------ESSASEAE----SHSGAVKSKH--------------------------RDDE 233 zebrafish
A1L1M4       206 GHSKTTs---------------------DASASGIGG---PLGSSVKNKH---------------------LD---DEED 237 zebrafish
XP_005814738 206 DDNQDTs---------------------NVLPSEG-----SPGSAVKNKH---------------------SDE--EEEE 236
Q5ZMU6       207 TEDKKHs---------------------DSPASDSEG---AQSSPVKNKH---------------------------SED 235 chicken
XP_014331120 208 TEEQHSs---------------------ETPPSEDEA---KPKHGIKHKH--------------------------REED 237
XP_003439001 208 VEEQGIs---------------------ETSLSEGEM---TPNSGIKNKH---------------------------PEE 236
CCD26948     286 QDDDYVDDNMGDTSGDDDDDDADENDEND 314
KRF93925     258 EDRDLKTDVT--EAAREIPEIEEPDEEEE 284
Q9W2U4       243 EKND--NDET--DSPHEAAEIEEPDEEVD 267 fruit fly
EKC35391     256 ESPPLKKSKLSDEISDEVPELASSKDDTR 284
Q6P964       234 DATHAETHEAKRLKFDKEEEEEEDDEEED 262 zebrafish
A1L1M4       238 EGMEEEEHEVKRLKFSQDGNEDEEDEDDV 266 zebrafish
XP_005814738 237 EDMEAEHQEVKRLKFCKDEEEEEQEVETP 265
Q5ZMU6       236 DPAEAEGHEVKRLKFDKEGEARDAPNQSA 264 chicken
XP_014331120 238 EESDCDKQEAKKRKTGEYDDETEREENES 266
XP_003439001 237 EDSDGDKQEVKRLKFDETEENETTSEKNE 265
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