5IWZ


Conserved Protein Domain Family
SYCP2_SLD

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pfam18584: SYCP2_SLD 
Synaptonemal complex 2 Spt16M-like domain
Synaptonemal complex protein 2 (SYCP2) N-terminal region contains two separate subdomains an ARLD (armadillo-repeat-like domain) and an SLD (Spt16M-like domain). The SLD structure is highly similar to the middle domain of the histone chaperone FACT. It consists of a twisted ten-stranded beta-sheet flanked by two helices. Since the SLD domain structurally resembles Spt16M, which is known as the well-recognized histone protein H2A-H2B; it is speculated that the SLD may be involved in chromatin binding.
Statistics
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PSSM-Id: 465811
Aligned: 22 rows
Threshold Bit Score: 150.118
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5IWZ_A        281 VYTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYI---AGDeEDHQWEAVTVPEEKVQMYNIEVRESKKLLTL 357 
XP_015220372  278 VYSYPCLEVFLDKHELFMPADDKLEEFWIDFNLGSQSITFYIstaDGE-EENQWDTVCIPKDEVEYYTVKEEKGQKVLTV 356 
XP_014342473  278 VFTYPCLEAFLDEHELLMPVDDKLEEFWIDFNVGSKSISFYIg-aENN-EEHQWETVSLPEDDIETYSVEEKDGKKLLTV 355 
XP_016793693  278 VFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIa--GDN-DDHQWEAVTVPEEKVQIYSIEVRESKKLLTI 354 
XP_023350248  278 VFTFPCLSVFLDRYELQIPSDEKLDDFWIDFNLGSQSISFYIs--GDD-EDHQWEAVNVSNDEVEKYNVEVKDTKKILTL 354 
XP_025041964  278 VFTYPCLSAILDKHELQIPLDENLEEFWIDFNIGSQSISFYIa--ADD-EDHQWETVSISEEEVKMYSLEEKESKKLLTI 354 
XP_008108446  101 VFTYPCLSANLDKHELQIPADDNLEEFWIDFNTGSRSISFYVa--ADG-EGHQWETVCVPEEEVKTYIIEEKDKNKLLTI 177 
RLV97525      282 VFTFPCLSAALDECELQIPLDENLEEFWIDFNIGSKSISFYVa--AED-ADQQWETVVIQEEDVNMYSLEEKDSKKLLTI 358 
XP_013044442  278 VFTYPCLSAALDKYELQIPLDENLEEFWIDFNIGSRSISFYVa--ADN-ADHQWETVIIPEEEVVLYNLEEKDSKKLLTI 354 
XP_016522627   70 VYTLPCLKAFLSSTQLFRPKDEKLDKFWIDFNVGSGCVSFFI---DDP-QSFLWGSIHLQMEDVDYYSLKFKQNEMVLCV 145 
5IWZ_A        358 TLKNIVKISKKEGKELLFYFDESL--EITNVTKKVFG 392 
XP_015220372  357 ILKQLLNSGGREGNRIQMYFSAAL--DIGEAVRHVYG 391 
XP_014342473  356 LMKNALNIDSKGGTQIRIYFDSGL--DILDVTRRLYG 390 
XP_016793693  355 ILKNTVKISKREGKELLLYFDASL--EITNVTQKIFG 389 
XP_023350248  355 FLKTTMNVGNKKGDQLVFYFDHLL--DILDVTKQIYG 389 
XP_025041964  355 ILKNPITMGNQEGEQLFLYFDPVL--EIMEVARKVYG 389 
XP_008108446  178 HLCNPMSVGVQEGDIITLHFDSAL--EILDAVKKVYG 212 
RLV97525      359 DLKSQMSVGTLEGQKFLLCFDSIL--EIKDVIIKIYG 393 
XP_013044442  355 DLKSPMNVGNQEGEKIFLYFDSIL--EIKDVTGKVYG 389 
XP_016522627  146 RLTNPIMHLNTRSHVVELTFDPEHqqELEEAAGRVFN 182 
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