Conserved Protein Domain Family
HCR

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pfam07111: HCR 
Alpha helical coiled-coil rod protein (HCR)
This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.
Statistics
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PSSM-Id: 284517
Aligned: 3 rows
Threshold Bit Score: 1012.36
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGW09065   1 MAPTWASDIPQFQSTFDQDVLERRqLDSQRPTVTMREQDVYGDGQGPGQRGRSLELRVSGALSQQAELISRQLQELRRLE 80 
Q8K2I2    27 MAPTWASDVPLVQSPASQDVLERR-LDAQRSTVTTWGQDFCGDGQGLGRRGRSLELGFSSALSQQAELISRQLQELRRLE 105 house mouse
Q8HZ60    27 MAPTWLSDIPLVQPPGHQDVSERR-LDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIARQLQELRRLE 105 chimpanzee
EGW09065  81 EEVRMLRETSLQQKMRLEAQAMEMDALAVAEKAGQAEAEGLRAALAGAEMVRKNLEEGNQRELQEIQTLHQEQLSSMTQA 160
Q8K2I2   106 EEVRSLRETSLQQKMRLETQAVELDALAVAEKAGQAEAEGLRTALAGAEMVRKNLEEAKHKELEEIQSLHQEQLSSLTQA 185 house mouse
Q8HZ60   106 EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQA 185 chimpanzee
EGW09065 161 HEMALASLTSKAEGLERALNSLEMKRAGEIKQLSVAQKETELLRGQLSKTQEELEAQVTLVESLRKYVGEQVPPEVHRQA 240
Q8K2I2   186 HQKALDSLASKAEGLEKSLNSLETKRAGEAKQLAMAQKEADMLRNQLSKTQEELEAQVTLVESLRKYVGEQVLPEFPSQE 265 house mouse
Q8HZ60   186 HEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQT 265 chimpanzee
EGW09065 241 WEPEREELLDTVQHLREDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPSDVLEPEYPKKCRSLLSSWREKVFVLM 320
Q8K2I2   266 WELERKELLDTLKHLKEDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPLDPLEPEFPKKCRSLLRNWREKVFALM 345 house mouse
Q8HZ60   266 WELERQKLLETMQHLQEDRDSLQATVELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALM 345 chimpanzee
EGW09065 321 VQLKAQDLEHRDSMKGLRDQVAELQEQVMAQSQEQAILQQALQDKAAELEVERMSIKTLQMELNRAQEARRRQKQRTDSV 400
Q8K2I2   346 VQLKAQDLQHRDSTSQLRIQVAELQEQVTSQSQEQAILQRALQDKTAQVEVERMSTKSLQMELDQAQEARRRQEQQIASA 425 house mouse
Q8HZ60   346 VQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASA 425 chimpanzee
EGW09065 401 EEQLKFVVSAMKSTQDSIHGTMTRLNQTVARIPSLSNRLSYAIRKVHTIKGLMARKVSLAQLRLQSCPPPPPAPPVDADL 480
Q8K2I2   426 EEQLKFVVGAMNSTQAKLQSTMTRMDQAVARIPSLSNRLSYAVRKVHTIKGLMARKVALAQLRVESSPPSEAAPPLDTDL 505 house mouse
Q8HZ60   426 EEQLRLVVNAVSSSQIWLETTMAKVEEAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLP---PPV-ADV 501 chimpanzee
EGW09065 481 SLELEHLREERNRLDAELQLSAHIIQQEVGRAREQGEAERLQLNEVAQQLEQELQRAQESLVNVGQQLESALQGQQESTE 560
Q8K2I2   506 SVELEQLREERNRLDAELQLSAHLIQQEVGRAREQGEVERRRLIEVAQQLEQELQRAQESLASVGQQLEAARRGQQESTE 585 house mouse
Q8HZ60   502 SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTE 581 chimpanzee
EGW09065 561 EAANLRQELTQQQQIYGQALQEKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHRATREKERNQELRRLQDEA 640
Q8K2I2   586 EAASLRQELTQQQEIYGQALQEKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHKATQEKERNQELRRLQDEA 665 house mouse
Q8HZ60   582 EAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEA 661 chimpanzee
EGW09065 641 RKEEAQRVARRVQELERDKNLMLatlrqegllsrykqQRLLAMLPLGTD-KKTvrfSPQ-PEVSPEHGCPAASPPRECTK 718
Q8K2I2   666 RKEEGQRLTRRVQELERDKNLML--------------QRLLAVLPSGVN-KKC---SPR-SVESSSSESPAAASCKESVK 726 house mouse
Q8HZ60   662 RKEEGQRLARRLQELERDKNLMLatlqqegllsrykqQRLLTVLPSLLDkKKSvvsSPRpPECSASAPIAAAVPTRESIK 741 chimpanzee
EGW09065 719 ESLTALFENLQGLSEAISREEATCPEDKQYTQ 750
Q8K2I2   727 GSLTVLLDNLQGLSEAISRDEDICVEDNQNTK 758 house mouse
Q8HZ60   742 GSLSVLLDDLQGLSEAISKEEAVCQGDNLDRC 773 chimpanzee
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