Conserved Protein Domain Family
PR-SET_ZFPM2
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cd19216: PR-SET_ZFPM2 
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins
ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.
Links
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Statistics
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PSSM-Id: 380993
Aligned: 6 rows
Threshold Bit Score: 210.898
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activeputative SAM
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus PRDM9 (4C1Q) binds H3k4me2 and S-adenosylhomocysteine (AdoHcy) through its PR-SET domain.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       ##                #                              ##### #         #
Q8WW38         97 WDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNnns--lkTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIV 174  human
OWK64064       97 WDGPGELEVVQKDGERKIQSRQQLPVGTTWGPFTGKMDLNnnt--lkTKASVPMVLTAGPKWLLDVTWQGVEDSKNNCIV 174  Bengalese finch
NP_001034724   97 WDGPRELGLFNKDGERRIHSRQQLPVGTTWGPFEGKIELNtd---aqTKPHVPLVLNTGPRWLLDVTWQGTDDNKNNCVV 173  zebrafish
OCT74950       44 WDGPGELELCQRDGEHKIHSRQQLPVGTTWGPFTGKMDLNnensplkTKPPVPVSLTDGPKWLLDVTWQGTEDNKNNCIV 123  African clawe...
XP_007900881   89 WDGPGELEVFQKSRERRVRSRQQLPGGTTWGPFNGRIGVTdss-slkTKAPVPVVVHAGPKWLMDVTWRGTEDNNNNCVV 167  elephant shark
NP_001034613   96 WDGPRELKIVCEGEERKICSCQALLLGTTWGPFPGKIEATt-----gGSDKVSLVLNGGPRWLMDIMWVSAEDGKSNCAV 170  zebrafish

Feature 1         #                       #        
Q8WW38        175 YSKGGQLWCTTTKAISEGEELIAFVVDFDSRLQ 207  human
OWK64064      175 YSKGGQLWCTTTKAISEGEELVAFVVDFDSRLQ 207  Bengalese finch
NP_001034724  174 YSKGGQLWCTTTKNMMEGEELVAFAVDFDSRLQ 206  zebrafish
OCT74950      124 YNKGGQLWCTTTKSIAEGEELIAFVVDFDSRLQ 156  African clawed frog
XP_007900881  168 YSKGGQLWCTTTKMLSEGEELIAFAVEFDSRLQ 200  elephant shark
NP_001034613  171 YSKGGHVWCSTTKNIMEGDELAACVVDLHSHLQ 203  zebrafish

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