Conserved Protein Domain Family
COE_DBD

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cl17007: COE_DBD Superfamily 
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.
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Statistics
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Accession: cl17007
PSSM Id: 450133
Name: COE_DBD
Created: 21-Mar-2012
Updated: 8-Mar-2022
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