Conserved Protein Domain Family
Arb1

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pfam09692: Arb1 
Argonaute siRNA chaperone (ARC) complex subunit Arb1
Arb1 is required for histone H3 Lys9 (H3-K9) methylation, heterochromatin, assembly and siRNA generation in fission yeast.
Statistics
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PSSM-Id: 430755
Aligned: 50 rows
Threshold Bit Score: 322.678
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003719165 178 TALNKIRG--TGFEDGYADPPMTVEEFEEEK-RIYDPETPFVDRIEECIQRYRGRRRL---DSTRDLMFSRYLNMGGIDT 251
EMR62883      17 kgGVLGRKnaSGFEEFYADPPVTPAESAEEK-NIYSVSRPFYDRMEECIQRFRAHRRL---NTERTNIFNKYLFMGGIDA 92 
ELR09322     149 SSGKKKKPnpTGFEEFYADPPITPEDHKEEVeQLYHFARPFAERIETCIQRYRARRKL---DEERANIFNKYISFGGIDT 225
XP_008087275  10 KTPKAPKVkpNGFEEFYADPPITPEEAIEERhDLYSPTRPFPDRIQTCIQRYRARRKL---DEIKANCFNKYLILGGIES 86 
XP_001590633 147 KSGANKKAapTGFEEFYADPPLTPNEYEEER-DVYH------------------ERKL---DSVRSNILTKYFALGGIEV 204
CCD52608     146 SGGKKKAAgpTGFEEFYADPPLTPDEYEEEC-DIYHKGRTFAARIETCIQRYRARRKF---DSTRANILTKYFALGGIES 221
XP_007291144 135 GSGKNKKApvTGFEEFYADPPITPAEQEEEE-DLYEWSRPVPERIETAIQRYRGRRKL---DEHRSNILTKYLMLGGVEA 210
Q9P7B8        31 LGNRRKKRglSGWEPYFQEPELTAEEKLENE-TLYSRNIPLTVRMERFIQRYRSRRKWs--DPTRIRLFTMYLDLGGVST 107 Schizosaccharom...
EPS43523      63 RKGGKGKTlpTGFEENFAEAPLTPAIFNQNK-ELYNPSKTVAERIETAVQKYKAKRKFsgaNVIRDQILRDYLLLGGINT 141
EPE06750      55 taLPKNRG--SGFEEYYAEPPLTVDEFEEEM-DLYHM------RIETSIQRYRARRRL---DNDRTNLFNRYLSVGGIDC 122
XP_003719165 252 SQRQFTGAngISKEDLAGLSKAEKRMAAANDVINRRgD---DPRWFTPGDE----GWTVDFAGVVAAYLSTRLPFDVAGE 324
EMR62883      93 HPRQFTG---MDPGTLADADKDEIRTMTAVDFIGGA-----GSRYFEIGDEe---HWEIDFEGVVKGFLSRTIPDIYMYD 161
ELR09322     226 TIKAFTGG--VDNEALEDFDGPTIADINATDVMYGGdEa--GSKFYDPCAPq---NWVVDFEGIAKAFLA---PYNFGIH 295
XP_008087275  87 TNKAFTGGa-LDDETLATTTADEIAAIQATDFVRPG-----NKKYYDPAESd---KWIVDWEGVAKGFL---IPTQLEME 154
XP_001590633 205 GTKTFNGG--LDKETLENSTAAEIAAIQATDFVRSS-----NSKYYDPSDTe---NWVVDWEGVVKGFLA---PKIMG-D 270
CCD52608     222 GAKTFNGG--LDQETLDNSTAAEIAAIQATDFVRAS-----NAKYYDPSDTe---NWVVDWEGVAKGFLSYRAPRILG-D 290
XP_007291144 211 TAKAFTGG--LDKETIENSTAAEIAAIQASDYVQAGtK---NSKYYDGSD-----DWVVDFEGVAKGFFSHRVPRIFPLD 280
Q9P7B8       108 GQKQFTGG--TDIN--NDAKAREVSAQTTTDYIEYDiLd----------------EYDIDFKWVAGVFLSSHILYNAGLT 167 Schizosaccharom...
EPS43523     142 AQKQFGG---VDQKFIREHDAEEIARFTATDYVPDKmKnigVERIEELDDDfeepEYEVDFNYVVRGFLTHRVPFSFGMK 218
EPE06750     123 TPRQFNGA--MGMHETEGMTASEKKTLGATDIVSQGgSa--LSKYYVSDNSh---LWAVDFSGVVSGFFSVSLRNLACSR 195
XP_003719165 325 -QDMMALGVDTILNFINYVIKHDVCPEYEADLARARAVCKLAKIEFPLINRALAGGMGQFNYACRTIFNL---------- 393
EMR62883     162 -PSAFEKAADLIKNFLNYVLMHNACPEYTDNIMAARNICDIFLPEMRATHELLDELPGSFNSAAAALFCG---------- 230
ELR09322     296 nQGLVNNYCNVVKNFLNYVLMHGVCPEYTKSIIAAQKVCDLAKFELPAIHDVGASFPGNFHKALSIMCHGcsrllyidpa 375
XP_008087275 155 sEQLIKLYCAVIKNFLNYVLQHEVCPEYVEDVMAARRICGQAEEELNAIRRLGKKLPGNFNIALSTLFGGvyfg------ 228
XP_001590633 271 gEDGVKMYCAVLRNFLNYVLAHEVCKEYTKDVMAARKICDIAEREYHSIRYLRQMFPGDFNVAASTLFGEyhkqhmeina 350
CCD52608     291 gAEEVTMFCGVVKNFLNYVLAHEVCKEYTKEVMAARRLCDVAEREFDAIRCLRQMFPGDFTVAASTLFGEnykrhfeins 370
XP_007291144 281 cEKDIMAITNVIRNFLNYILQHEVVPEFTKDIMAARALCDLAEQELWAIHVLNFKLPGDFGIAASTLYGGrfkglclene 360
Q9P7B8       168 kEEDLQIACQIVRNFLLSVLHNNVAPEFEDNIRDACLLAEQAETELISNKRLSTKLPGRLQRALASIHVDnykglwdksq 247 Schizosaccharom...
EPS43523     219 tTENIDIAVGTIRNFLNWIIYHNVCPEHTDNLKLALKTCDMAAQELPICSILSDQFPGELNKACSTLFGGywsmitpq-- 296
EPE06750     196 -KQLIPVGIDVVDNFMRYLQIHDVCPEYDEDIKAARAICTQAHTELPNCFEVLRQMPGQFNRACTKLFWHetdss----- 269
XP_003719165 394 ----------------------SDETDCF-VDRMSVDPARnrpvrpiLVFTSTLTLLADMYPAARTIdlhklrdedptmd 450
EMR62883     231 ------------------------------DRTVDNLDKQenfdklvNFRLIALETTTNEEVRKKlakl----------d 270
ELR09322     376 s-------------------ipdhpadadpNQYMSIDQAH-------RTFRAAMALMGTAEQFAAVAvtsl--------k 421
XP_008087275 229 ------------------inqaDQPWQEH-AIGMTVEKAE-------EVLKKGVQALDalgy-----------------v 265
XP_001590633 351 awv---------------dvedgseqwctnVPLLSLPVCR-------FVFGGIVAFLGNKShfek--------------a 394
CCD52608     371 awa---------------npeddlsqwntnIPVLSLPVCQ-------FVFGGIVAFIGDKShfdk--------------a 414
XP_007291144 361 gwv---------------kedpnfaemmslNQGFSDEKAS-------RIFMTSVAFAGDDElfvk--------------t 404
Q9P7B8       248 sdrtsdssvnfiesnntkfmpnDELFEPDgISRFSTQQAR-------DYIQRTLGPr----------------------- 297 Schizosaccharom...
EPS43523     297 ---------------swekvdgEE-IKKT-EPGVSYERAR-------STYQALLPELpfqn------------------e 334
EPE06750     270 ------------------lfhgGLDPLQW-AVDPEGNEVKddgmendAVFRATVALQKNVVGPTALaaak---------g 321
XP_003719165 451 klAGAISSESRADYYEVVETREPSEPIARLFRALHSGDKVTGHYKPAGVLVVRRciv------edgFANtPKLHMMPLtr 524
EMR62883     271 dpAIVRDSETKEETYEVYEIARPRRQYIKMFEEQLKQMQMPGKVKPAGRVLLKPaii------ehsYDNlPRPDDVDLsg 344
ELR09322     422 eyQAPAVVSEELRGFEVVGITLPGEALSKSFAGIRAADGRTGTIKPVGLLACNS------------WTH-PYQPTLDLti 488
XP_008087275 266 wkKADIVVISSTRDYEVTAIELPKE-----------------EDGMLGFFKCKP------------WEG-PQSDVYEApn 315
XP_001590633 395 kkGDAQVVDIENKFIEVVDVHLATANIVAEFSRVKDPRGLG-ALKPVGKLLCKS------------WEG-PGYDYEDKtd 460
CCD52608     415 knGDIHVVTIETRFIEVADVHRASANVVKEFSHVKDPRGLG-ALKPIGKLLCKS------------WEG-PGFAYEDKtd 480
XP_007291144 405 seGNLRIVKTEVKFLEAIKIKRASVESIETYAGVTDHEGKPGKIKPLGSIWYKA------------WEG-PGFDDEDLtd 471
Q9P7B8       298 -yLTGKVVEQEYLTVKLVSk---------------------tLLNFSNQSLCKAvf--------ivWDP-PGSKYSQDtn 346 Schizosaccharom...
EPS43523     335 sgDLPTEVYREYGSFEVISTWLPEPGSPLI----------------LGKIHCQSwtpeesspieskWGG-PD-------- 389
EPE06750     322 dlSEIRVVSTKILDLEIASLVTPSDEKRQQYAEKDE------KLRPAGIVISKHyci------eagIANqPHPSDEELaa 389
XP_003719165 525 g----------kddVASFIVDRDLLRCLLPGMNLHLETARIthpDFELTIVKNLLDVQPSFRLFLPQMLMLDYKMP 590
EMR62883     345 ------------apVEEYLVEDEILAKLQRGMKLKLVVCEL---NIGIRFIKEVHDIRVSFDTFLPQTLMAGWKDP 405
ELR09322     489 eeeqglaanppvygDETFWVDEDILERCFAGMKFVGVVREL---DLGVRYLDNVIVIYASFYTFVENERMVNWKAP 561
XP_008087275 316 ktp-------lstqEETFYVDADIIELIQVGMKVEMIVREI---DNGFKFFDHA-GFFCSFYTCLENEKMVDWKEP 380
XP_001590633 461 dgne-----vvddsVEEFWLEDEILQHCYPGLKLEVVVHEL---NIGVKYFDQVIDVFPSFHLYLPNEKMLGWKEP 528
CCD52608     481 dgid-----elddsIEEFWIEDEILQQCYPGLKLEVVVHEL---NIGVKYFDQVVEFFPSFHLYLPNEKMMGWKEP 548
XP_007291144 472 eeieaakialatapVEKFWLEDDILQDCFEGMKIEATVHEL---NTGLKFIDSFKGVFCSFHTILPNEKLVGWKEP 544
Q9P7B8       347 ------------keRLEVILESDLLNNTVDGTHLEGSFTFL---DNGLTILDTVLAVLPTFYEEVKDE-------- 399 Schizosaccharomyces...
EPS43523     390 --------------GLTLYCEKIIAQYVYPKMHICCTLHEL---DNGFIYFDEITGVMCSDFLEIRDD-----KEL 443
EPE06750     390 ------------rgMVAFFLDATTMEMLTVGMKLRVVMHEL---SCDLNFVSAIKEVLPSFYMYLPQELMTEFKEP 450
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