2Z2U,2YX0


Conserved Protein Domain Family
rSAM_TYW1
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TIGR03972: rSAM_TYW1 
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wyosine biosynthesis protein TYW1
Members of this protein family are the archaeal protein TWY1, a radical SAM protein that catalyzes the second step in creating the wye-bases, wyosine and derivatives such as wybutosine, for tRNA base modification. [Protein synthesis, tRNA and rRNA base modification]
Links
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Statistics
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PSSM-Id: 274890
Aligned: 29 rows
Threshold Bit Score: 434.759
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2Z2U_A         6 IYKILRKQRYQID--G---HTAVKLCGWVRKKMLEDKNCYKSKFYGIETHRCIQCTPSVIWCQQNCIFCWRVLP--RDI- 77  Methanocaldococ...
WP_011033292  63 FATLLKKQGYALA--Gr--HSAVKTCLWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLM-CNQRCLFCWRPTE--VPV- 134 Methanosarcina ...
WP_011499770  18 feTLLKKQKYSLA--Gt--HSAVKTCLWLSRSIKDQGECYKSKFYGITSHCCLQMTPTLR-CNQRCLHCWRPTE--VEVs 90  Methanococcoide...
WP_012034466  10 LIDLLRKQGYHIL--Gr--HSAIKPCLWLNRSIKAKGSCYKAQFYGISSHRCVQMTPCVA-CNQRCLHCWRPVE--EPF- 81  Methanocella ar...
WP_011845046   5 ACKALKKQGYQFI--TptsSAAVKPCMWNKRALKGGEMCYKAQFYGIESHRCVQMTPTLK-CNQQCLFCWRSFE--HEV- 78  Methanoculleus ...
WP_011695599   2 DPAALERQGYHLV--Ge---GAVKPCLWLKRSLRGREQCYKHHFYGIESHRCVQMTPVLH-CNHLCLHCWRPVDdsFPL- 74  Methanosaeta th...
WP_011449784   9 sKKALRRMGYQFF--HpdsSAALKPCLWCKRSLSGGDQCYKNQFYGITSHRCVQFTPTLR-CNHTCLFCWRSFE--HEY- 82  Methanospirillu...
WP_011991282   5 PCDARIRQGYLFF--SpksSAALKPCLWCKRALTGGDMCYKHQFYGIDSHRCVQMTPTLR-CNQRCLFCWRSFE--HEV- 78  Methanoregula b...
WP_011973210  11 IYTVLRKQHYQIKe-----HSAVKLCGWVKKALLENKSCYKSKFYGIATHRCIQCTPSVIWCQQSCIFCWRALP--SDI- 82  Methanococcus a...
WP_011832913  11 PKTCLHRQGYNFIaeGa--SAAVKPCMWCKRALRGGESCYKHQFYGIDTWKCVQMTPTLR-CNQRCLFCWRSME--HEI- 84  Methanocorpuscu...

2Z2U_A        78 -G--ID-ISQikep-kweePEVVYEKILAMHKRIIMGYAGVl-DRVGEKKFKEALE-PKHVAISLSGEPTLYPYLDELIK 150 Methanocaldococ...
WP_011033292 135 -PapGE-WDF---------PEKIVEESIACQRKLITGFGGS--PNALRERWLEGNQ-PNNVAISLSGEPTFYPYLPELIE 200 Methanosarcina ...
WP_011499770  91 lP--NN-WDS---------PVEIVGSSIKAQRKLITGFGHS----APRERWIEANE-PKHVAISLSGEPTLYPYLPELVE 153 Methanococcoide...
WP_012034466  82 -T--IEsWDK---------PELIAEQAIAEQLRFVSGYGGT--DSADKAIWKEAFK-PKHAAISLVGEPTLYPYLDELIE 146 Methanocella ar...
WP_011845046  79 -V--EEee---------cpPDVIVENLRRVQKRALSGYKVS--PYVAPERFAEALD-PTMVAISLSGEPTCYSRLPELVD 143 Methanoculleus ...
WP_011695599  75 -P--ER-WTE---------PEDLLDLVLREQRRILSGYWGS--DVVDRARLQDAST-PKHVAISLMGEPTFYPHLRGLIK 138 Methanosaeta th...
WP_011449784  83 -T--GE-KDl--------lPQEIVSRIPFLQKKALGGYKVS--PKVTKEKWEEALQ-PDQYAISLAGEPTLYPHLPELID 147 Methanospirillu...
WP_011991282  79 -E--EE-EECpp--------eTILAGVPKLQKKALAGYNSVlgNTVTDERWQEALK-PRHVAISLSGEPTLYSRLPELVD 145 Methanoregula b...
WP_011973210  83 -G--MD-NNSnykmpkwdePEIVAENILKMHNTLITGYKGIl-DRIGEQKYNELAN-PKHVALSLSGEPTIYPYFKELIE 156 Methanococcus a...
WP_011832913  85 -------LSEte-----lsPEEIVAAIPKMQKKGLSGDK----PYTEPERWEEATDhPTQYALSLSGEPTLYSKLPELID 148 Methanocorpuscu...

2Z2U_A       151 IFHKN-GFTTFVVSNGILTDVIEKIEPTQLYISLDAYDLDSYRRICGGK--KE---YWESILNTLDILKEKK----RTCI 220 Methanocaldococ...
WP_011033292 201 EYEKR-GFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYLRICQPK--SPa--LWDRINESLDIMKDKSs---RTVI 272 Methanosarcina ...
WP_011499770 154 EYESQ-GFSTFVVSNGTVPEMMEKIEPSQLYMSLDAPDKETYEKVCLPK--SPa--LWDKINRSLEILGTKNn---RKAI 225 Methanococcoide...
WP_012034466 147 LFKSK-EMSTFIVTNGTRPDVLAQIsPSQLYMSLDAPDHETYLATCNP---AGd--LWNKVQESLEVLGSRPq--qRRAL 218 Methanocella ar...
WP_011845046 144 ALNAD-GYTTFLVSNGTRPDVLARCRPYQTYVSLDAPDRETYLALCRP---REd--YWDRIHESLAGLRER-----RSAI 212 Methanoculleus ...
WP_011695599 139 AINER-GMTSFLVTNGTNPDVLKDVdPTQLYISINAPDEDTYRRVSG-----Gr--DWNRILESLAMMRDLRc---RTVV 207 Methanosaeta th...
WP_011449784 148 LLNQT-GGTTFLVSNGTMPDVLKRCHPYQKYISLTAPDRETYLRIARP---REd--YWDQVLESISCLGHETdagdRTAI 221 Methanospirillu...
WP_011991282 146 LFNAN-GYTTFVVSNGTNPDMIARCRPFQQYISLDAPDCETYERACRPMgnAEa--FWDRIRESLGKLRAK-----RSAV 217 Methanoregula b...
WP_011973210 157 IFHKK-GFSTFVVSNGILTEVIEEINPTQLYISVDAYDLDSYKKICRGT---Et--QWNKIMDTLDILNDKK----RTCL 226 Methanococcus a...
WP_011832913 149 LLRENpNNSVFVVSNGTMPSVIRRIRPTQLYLSLDAVDESSYERICRPI--GDpaaMWGNIQTSLSLLKQKEeegvRTAV 226 Methanocorpuscu...

2Z2U_A       221 RTTLIRGYNDDILK-FVELYERADVHFIELKSYMHVGYSQKRLKKEDMLQHDEILKLAKMLDENSSYKLIDDSEDSRVAL 299 Methanocaldococ...
WP_011033292 273 RTTLVKGENIFNPEgYAEMIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHEEVLEFSKELAKHLGYEIADESEISRVVL 352 Methanosarcina ...
WP_011499770 226 RITLIKGLNMFDTAgYGRLIEKADPDYIEVKAYMHLGYSRGRLPREAMPAHDEVLEFAKELAGHIGYSVADDVEVSRIVL 305 Methanococcoide...
WP_012034466 219 RITLVKGLNMKDPAgYARQISTAKPDYVEVKAYMHLGYSRYRLPREAMPRHAEVLEFAKDVAAACGYKLAMDVELSRVVL 298 Methanocella ar...
WP_011845046 213 RTTVVRGYNDFSPErYAAIYQDSGARFVEVKGYMYLGYSRNRLQRTQMPEHSEVRAFAEKIAEYCDYCIMDESPVSRVVC 292 Methanoculleus ...
WP_011695599 208 RITLIRGVNMFNPDaYARLL-DAEPDFVEVKAYMHLGRSRYRLSRDAMPSHEEVVSFASALAESMGYTLEDQVSLSRVAL 286 Methanosaeta th...
WP_011449784 222 RVTLVRGINDQDPEgYARIIQESGAQFVEVKAYMHVGYSQRRLTIKHMPLHDEIEHFTKRMLPHLSYRVLGENTLSRVIC 301 Methanospirillu...
WP_011991282 218 RITLVAGVNDTDPEgYARIIQDSGATYVEVKGYMYLGYSRNRLQRNNMPEHAQVRDFAERVSASCDYTIRDENPLSRVVC 297 Methanoregula b...
WP_011973210 227 RTTIIRDYNDDI-EkFIPIYEKANANLIELKSYMNVGYSRKRLNLDDMLKHEEILELSKILDNNSFYKLEDDAFDSRVSV 305 Methanococcus a...
WP_011832913 227 RITLVNEYNDTYEAgFAKIIEEAQPLFVEVKGYMYLGYSRMRLTEMHVPDMETIRRFAAGVAQLCNYEIMDENVPSRVVC 306 Methanocorpuscu...

2Z2U_A       300 LQ 301 Methanocaldococcus jannaschii
WP_011033292 353 LS 354 Methanosarcina mazei
WP_011499770 306 LS 307 Methanococcoides burtonii
WP_012034466 299 LS 300 Methanocella arvoryzae
WP_011845046 293 LE 294 Methanoculleus marisnigri
WP_011695599 287 LT 288 Methanosaeta thermophila
WP_011449784 302 LE 303 Methanospirillum hungatei
WP_011991282 298 ME 299 Methanoregula boonei
WP_011973210 306 LM 307 Methanococcus aeolicus
WP_011832913 307 Lk 308 Methanocorpusculum labreanum
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