1N89,1TUK,1L6H


Conserved Protein Domain Family
nsLTP2
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cd01959: nsLTP2 
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nsLTP2: Non-specific lipid-transfer protein type 2 (nsLTP2) subfamily; Plant nsLTPs are small, soluble proteins that facilitate the transfer of fatty acids, phospholipids, glycolipids, and steroids between membranes. In addition to lipid transport and assembly, nsLTPs also play a key role in the defense of plants against pathogens. There are two closely-related types of nsLTPs, types 1 and 2, which differ in protein sequence, molecular weight, and biological properties. nsLTPs contain an internal hydrophobic cavity, which serves as the binding site for lipids. nsLTP2 can bind lipids and sterols. Structure studies of rice nsLTPs show that the plasticity of the hydrophobic cavity is an important factor in ligand binding. The flexibility of the sLTP2 cavity allows its binding to rigid sterol molecules, whereas nsLTP1 cannot bind sterols despite its larger cavity size. The resulting nsLTP2/sterol complexes may bind to receptors that trigger defense responses. nsLTP2 gene expression has been observed in barley and rice developing seeds, during Zinnia elegans cell differentiation, and under abiotic stress conditions in barley roots. The nsLTP2 of Brassica rapa has also been identified as a potent allergen.
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Statistics
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PSSM-Id: 238925
Aligned: 25 rows
Threshold Bit Score: 73.887
Created: 16-Nov-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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hydrophobic
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:hydrophobic cavity
Evidence:
  • Comment:nsLTPs contain an internal hydrophobic cavity which serves as the binding site for lipid-like molecules. This cavity exhibits high plasticity to accommodate a variety of ligands.
  • Structure:1N89_A; Durum wheat nsLTP2 binds PGM phospholipid; defined at 3.5A contacts.
  • Structure:1TUK_A; Bread wheat nsLTP2 binds two PGM phospholipid molecules; defined at 3.5A contacts.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #                           #    # # #  ###              # # 
1N89_A      2 CQASQLAVCASAIlsgakPSGECCGNLRAQqGCFCQYAKdPTYGQYIRSphardtltSCGLAVpHC 67  durum wheat
NP_973968  32 CDFTKFQVCKPEIitgspPSEECCEKLKEQqSCLCAYLIsPSISQYIGNakr--virACGIPFpNC 95  thale cress
P83506      4 CNPAQLTPCAGPAlfggaVPPACCAQLRAQqGCLCGYARsPNYGSYIRSpnaarlfaICNLPMpRC 69  maize
BAD53591   30 CNPSALSPCMSAImlgaaPSPGCCVQLRAQqPCLCQYARdPSYRSYVTSpsaqravkACNVKA-NC 94  Japanese rice
BAC43108   35 CTVTELQPCLPSVidgsqPSTQCCEKLKEQnSCFCDYLQnPQFSQYITAakq--ilaACKIPYpNC 98  thale cress
BAB11283   38 CDATQLSSCVTAVstgapPSTDCCGKLKEHeTCLCTYIQnPLYSSYVTSpnarktlaACDVAYpTC 103 thale cress
P82353      3 CSPVQLSPCLGPInsgapSPTTCCQKLREQrPCLCGYLKnPSLRQYVNSpnarklasNCGVPVpQC 68  apricot
NP_176857  37 CDARQLQPCLAAItgggqPSGACCAKLTEQqSCLCGFAKnPAFAQYISSpnarkvllACNVAYpTC 102 thale cress
NP_568555  30 CIPTELMPCLPAMttggqPTKDCCDKLIEQkECLCGYINnPLYSTFVSSpvarkvleVCNIPYpSC 95  thale cress
BAD82487   38 CDPLALRPCAAAIlwgeaPSTACCAGLRAQkRCLCRYAKnPDLRKYINSqnsrkvaaACSVPApRC 103 Japanese rice

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