1J08,2HLS,2AYT


Conserved Protein Domain Family
GlrX_arch

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TIGR02187: GlrX_arch 
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Glutaredoxin-like domain protein
This family of archaeal proteins contains a C-terminal domain with homology to bacterial and eukaryotic glutaredoxins, including a CPYC motif. There is an N-terminal domain which has even more distant homology to glutaredoxins. The name "glutaredoxin" may be inappropriate in the sense of working in tandem with glutathione and glutathione reductase which may not be present in the archaea. The overall domain structure appears to be related to bacterial alkylhydroperoxide reductases, but the homology may be distant enough that the function of this family is wholly different.
Statistics
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PSSM-Id: 274021
Aligned: 8 rows
Threshold Bit Score: 290.115
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1J08_A         4 ISEEDKRIIKEEfFSKMVNPVKLIVFIG--------KEhCQYCDQLKQLVQELSELT------D------K------LSY 57  Pyrococcus hori...
AAS80834       4 LGPKEQEIVRER-LANLTRDVEMVLFTDsstliapgKEpCLYCKETKQLLEELSALS------D------K------LHL 64  Thermus thermop...
WP_004080736   4 LSDKDIAYLKDLfGKELKRKVKIVFFKTe------dKTrCQYCEITEQVLEELVSVD------P------K------LEL 59  Thermotoga
CAC11272       5 IRKEDREYLKGEfEKYLKNDVDLVVFTSn------dEN-CRYCKETVQLATEVSEIN------P------K------IHL 59  Thermoplasma ac...
WP_010880251   3 LNLDVRMQLKELaQKEFKEPVSIKLFSQai--------gCESCQTAEELLKETVEVIgeavgqD------K------IKL 62  Aquifex aeolicus
WP_009990430   9 FSDEVKNALQDa-LKDMKNPVDVYVFVDn------tDSnCQYCGVTTKFLEFMASAA------P------KdsngslLKV 69  Sulfolobus solf...
2HLS_A         9 LSEDFRRELRET-LAEMVNPVEVHVFLS--------KSgCETCEDTLRLMKLFEEES------PtrnggkL------LKL 67  Aeropyrum perni...
2AYT_A         3 LNLDVRMQLKELaQKEFKEPVSIKLFSQ--------AIgCESCQTAEELLKETVEVIgeavgqD------K------IKL 62  Aquifex aeolicus
1J08_A        58 EIVDFDtpEGKELAEKYRIDRAPATTITQdGkd-fGVRYFGIPAGHEFAAFLEDIVDVSKGDTDLMQDSKEEVSK-IDKD 135 Pyrococcus hori...
AAS80834      65 VVYDLAtpEGKEKAGAYKVEAAPTLILREkGseaiNLRYRGIPAGYEFASLLEDIEMLGRDGHGLPENVVQELND-LPEE 143 Thermus thermop...
WP_004080736  60 EIHDFD--SDKEAVEKYQVEMVPATILLPeDgkdyGIRFYGVPSGHEFGTLIQDIITVSEGKPQLSEESIQKLQS-LEEP 136 Thermotoga
CAC11272      60 KVYNFD--EDKEMVKKYGVEKYPATIVSKaGvedgRIVYYGLPSGYEFGSLIEDLKNVSMGEADVSSKAAELISK-IDKP 136 Thermoplasma ac...
WP_010880251  63 DIYSPFt--HKEETEKYGVDRVPTIVIe--GdkdyGIRYIGLPAGLEFTTLINGIFHVSQRKPQLSEKTLELLQV-VDIP 137 Aquifex aeolicus
WP_009990430  70 HIVDRAneNSRKIFEEFNVERVPTVAFYNg-----YIRWTGAPLGEEIRALVETIVRLSQGESGLSQETVEAIKSkLNGK 144 Sulfolobus solf...
2HLS_A        68 NVYYREsdSDK--FSEFKVERVPTVAFLGg-----EVRWTGIPAGEEIRALVEVIMRLSEDESGLEDATKEALKS-LKGR 139 Aeropyrum perni...
2AYT_A        63 DIYSPFt--HKEETEKYGVDRVPTIVI-EgDkd-yGIRYIGLPAGLEFTTLINGIFHVSQRKPQLSEKTLELLQV-VDIP 137 Aquifex aeolicus
1J08_A       136 VRILIFVTPTCPYCPLAVRMAHKFAIEN-----TkagkgK-----ILGDMVEAIEYPEWADQYNVMAVPKIVIQVNGEdk 205 Pyrococcus hori...
AAS80834     144 VVLQVFVTPTCPYCPQAVRTAHRLAYAS-----P-----K-----VWGEMIEANEFPALSDRYHIHGVPDTIINHGKEr- 207 Thermus thermop...
WP_004080736 137 IRISVFVTPTCPYCPRAVLMAHNMAMAS-----D-----K-----IIGEMIEANEYWELSEKFGVSSVPHIVVNRDPSk- 200 Thermotoga
CAC11272     137 ITIKVYVTPTCPYCPRAVGTAHKFALLN-----P-----N-----IKGEMIEALEFENEAEEVGVSSVPHIVINNDVT-- 199 Thermoplasma ac...
WP_010880251 138 IEIWVFVTTSCGYCPSAAVMAWDFALAN-----D-----Y-----ITSKVIDASENQDLAEQFQVVGVPKIVINKGVAe- 201 Aquifex aeolicus
WP_009990430 145 VKIETVVTPSCPYCPYAALMAHMVAFEAcragkC-----N-----VISEVIEAYENQDIAEKYQVMSVPAIAINESIE-- 212 Sulfolobus solf...
2HLS_A       140 VHIETIITPSCPYCPYAVLLAHMFAYEA-----W-----KqgnpvILSEAVEAYENPDIADKYGVMSVPSIAINGYLV-- 207 Aeropyrum perni...
2AYT_A       138 IEIWVFVTTSCGYCPSAAVMAWDFALAN-----D-----Y-----ITSKVIDASENQDLAEQFQVVGVPKIVINKGVAe- 201 Aquifex aeolicus
1J08_A       206 vqFEGAYPEKMFLEKLLSA 224 Pyrococcus horikoshii
AAS80834     208 --VLGAQPLSQFLQAIRKA 224 Thermus thermophilus HB27
WP_004080736 201 -fFVGAYPEKEFINEVLRL 218 Thermotoga
CAC11272     200 --FIGAYPDDQFAEYVMEA 216 Thermoplasma acidophilum
WP_010880251 202 --FVGAQPENAFLGYIMAV 218 Aquifex aeolicus
WP_009990430 213 --FIGVPYEENFINAILEK 229 Sulfolobus solfataricus
2HLS_A       208 --FVGVPYEEDFLDYVKSA 224 Aeropyrum pernix K1
2AYT_A       202 --FVGAQPENAFLGYIMAV 218 Aquifex aeolicus
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