4ZR0


Conserved Protein Domain Family
FA_hydroxylase

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pfam04116: FA_hydroxylase 
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Fatty acid hydroxylase superfamily
This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.
Statistics
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PSSM-Id: 397991
Aligned: 110 rows
Threshold Bit Score: 44.3434
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4ZR0_A       229 FCVGVFVWTLIEYGLHRfLFHFdd----wLPesniAfaTHFlLHGC-HH-YLPMDK-YRLVMPPTLFVILCA--PFYKLV 299 Saccharomyces c...
Q06AR9       150 SVGAAVGMEFWARWAHRaLWH--------AS-------LWH-MHES-HHkPREGPF-ELNDVFAIINAVPAI--ALLNFG 209 Adonis aestival...
Q6X3I7        47 AALGLVAWSLLEYLLHRfVLHG-------LS-------PFRqWHQS-HH--QRPGA-LIGLSTLSSAALFIG--LVYLPA 106 Pseudomonas aer...
Q1DFV0        44 MLAASVAFPFGWYLVHKhILHSr-----fLYksplTaaTWKrIHFD-HH--QDPHD-LRVLFGALANVLPTVggVIAPIG 114 Myxococcus xant...
Q5NMN7        19 IAVAILGFPLVWYVTHRwIMHGh-----wMFkvpfLsgLWKrIHYD-HHlDPDHLEvLFGALYTTLPSVALAtaLPGY-- 90  Zymomonas mobilis
Q0RCQ7        69 AMAAALAQPFVEWGVHRlLLHArp----aSRlgavGyqLAGyGHEQ-HHrDPAD---LDTMFLRPREVITGT--AAAALP 138 Frankia alni AC...
Q5Z3I7        53 PLVMVAVFPVFEWVVHVlVLHWrpkrlgrLT----LdsELArKHRE-HHiDPREIP-LIFIPTRSLVIVLVA--LLLIAA 124 Nocardia farcinica
WP_006969409  63 VAAILAVHPFAEWIIHVfILHHrprtvtvLGkplrWdyDAArKHRL-HHrDPWDIR-HVLIPLPILAFGLSL--NGSVAL 138 Plesiocystis pa...
ABL97308      43 FFIPIILAPFYEWYVHKyQLHRe------LTkkegW---YRrYQIIlHHgHHRDPD-NIKLQFAPWRYLIYTy-GQVYLL 111
Q6B3A6        39 MLAGLLVWSLLEYSLHRfLFHS----------------LYRrEHWT-HH--VDVLA-YIGVSSWKISSVYSG--LLLFAS 96  uncultured prot...
4ZR0_A       300 FALLP--LYWAYAGfaGGLFGYVCYDECHFFlHhSKLPPFm-------RKLKKYHLEHHY-KNYQLGFGVt-SWF-WDEV 367 Saccharomyces c...
Q06AR9       210 FFHKGliPGLCFGAglGITVFGMAYMFVHDGlVhRRFPVGpianvpyfRKVAAAHQIHHTdKFQGVPYGLflGPKeLEEV 289 Adonis aestival...
Q6X3I7       107 LLALG--PWRGSSLalGIMSGYLAYILTHHAvHhFDHSGNaw-----lARRQLCHHLHHSaLWQAGHFGVt-SAF-WDRL 177 Pseudomonas aer...
Q1DFV0       115 YLIGG--KAGAAAAlgWAMVITCFYEFCHCI-QhLNYTPKsq----flKDIKRLHLSHHF-HNEQGNYGIt-NYF-WDRL 184 Myxococcus xant...
Q5NMN7        91 -LIGG--FGGACIGyaVGLLSTCFYEFCHCI-QhLGYKPKnk----rlALMKKRHLEHHF-HDEDGNFGIt-NFF-WDKL 159 Zymomonas mobilis
Q0RCQ7       139 A-LFG--PPSAATGalCAGVGVLAYDWTHFL-IhTRVPPRta----yyRRLWRGHRLHHY-RNERYWLGVt-SPL-GDLA 207 Frankia alni AC...
Q5Z3I7       125 FAFPR--PGLGLTFllTVTVLGLGYEWTHYL-IhTDYKPRra----lyRAVWRNHRHHHY-KNEHYWFTVtsSGT-ADRL 195 Nocardia farcinica
WP_006969409 139 AVLPT--PGLAGTFaaTIAAIVLYYEWIHFL-VhTSYRPRga----lyRRQWRLHRLHHF-KNERYWLGVt-RHF-GDRA 208 Plesiocystis pa...
ABL97308     112 YSLILwsFPAAMVPftGHLVYHLWYEWIHLAhHsKEYKPVsi----igKKLRDAHMSHHF-HNENYNWGI--TNMiGDYF 184
Q6B3A6        97 FAGLT--SAFAGLVlgYFTYISLHYV-MHRP-----RHWAyr----fiPRLVANHDLHHR-KGVEKNFGVs-SPL-WDHL 161 uncultured prot...
4ZR0_A       368 FGT 370 Saccharomyces cerevisiae S288C
Q06AR9       290 GGN 292 Adonis aestivalis var. palaestina
Q6X3I7       178 FAS 180 Pseudomonas aeruginosa
Q1DFV0       185 FGT 187 Myxococcus xanthus DK 1622
Q5NMN7       160 LGT 162 Zymomonas mobilis
Q0RCQ7       208 LRT 210 Frankia alni ACN14a
Q5Z3I7       196 FGT 198 Nocardia farcinica
WP_006969409 209 LGT 211 Plesiocystis pacifica
ABL97308     185 FGT 187
Q6B3A6       162 FRT 164 uncultured proteobacterium QS1
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