Conserved Protein Domain Family
SLC6sbd_SBAT1
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cd11522: SLC6sbd_SBAT1 
Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain
SBAT1 (also called B0AT2, v7-3, NTT7-3) is a high-affinity Na(+)-dependent transporter for large neutral amino acids, including leucine, isoleucine, valine, proline and methionine. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Links
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Statistics
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PSSM-Id: 212091
Aligned: 5 rows
Threshold Bit Score: 1129.25
Created: 20-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
Q9H2J7        61 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKL 140 human
Q9XS59        61 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYISPQL 140 cattle
CAK11130      68 RPAWGSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLVPYLILLLLIGIPLFFLELAVGQRIRRGSIGVWNYISPHL 147 zebrafish
XP_416124     61 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLVPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYISPKL 140 chicken
XP_003221168  61 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLVPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYISPKL 140 green anole

Feature 1                                                      #                                 
Q9H2J7       141 GGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISE 220 human
Q9XS59       141 GGIGFASCVVCFFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNASHTFVEPECEKSSATTYYWYREALNISTSISE 220 cattle
CAK11130     148 GGIGFASCLVCFFVALYYNVIIGWSLFYFSQSFQQPLPWHECPLVKNKTNTYIEPECEKSSATTYYWYRVALDISDSISE 227 zebrafish
XP_416124    141 GGIGFASCIVCFFVALYYNVIIGWSLFYFSQSFQHPLPWDQCPLVKNASHTFVEPECEKSSATTYYWYREALNISSSLSE 220 chicken
XP_003221168 141 GGIGFASCIVCFFVALYYNVIIGWSLFYFSQSFQHPLPWDQCPLVKNSSHTFVEPECEKSSATTYYWYREALNISSSISE 220 green anole

Feature 1                                                                                        
Q9H2J7       221 SGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR 300 human
Q9XS59       221 SGGLNWKMTICLLAAWVVVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRALLLNGSVDGIRHMFTPELEIMLEPKVWR 300 cattle
CAK11130     228 GGGLNWRMTLCLLAAWTMVCLAMIKGIQSSGKVMYFSSLFPYVVLICFLARAFLLKGSVDGIIHMFTPKLEIMLEPKVWR 307 zebrafish
XP_416124    221 SGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLLCFLVRGLLLNGSLDGIRHMLTPKLEIMLEPKVWR 300 chicken
XP_003221168 221 SGGLNWKMTVCLLAAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRGLLLNGSLDGIRHMFTPKLEIMLEPKVWR 300 green anole

Feature 1                                                                                        
Q9H2J7       301 EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLk 380 human
Q9XS59       301 EAAAQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSILATLVVFAVLGFKANVINEKCIAENSEMIIKLVk 380 cattle
CAK11130     308 EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANIMNAKCVEMNTKKIIGFLg 387 zebrafish
XP_416124    301 EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANIINEKCVIQNSEKILKLLk 380 chicken
XP_003221168 301 EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCIIQNSERIVNLLh 380 green anole

Feature 1                                                                                        
Q9H2J7       381 mgnisqdIIPHHINLSTVTAEDYhlvYDIIQKVKEEEFPAlhLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWS 460 human
Q9XS59       381 mgnisqdIIPHHINFSAITAEDYdliYDIIQKVKEEEFPAlhLNACQIEDELNKAVQGTGLAFIAFTEAMTHFPASPFWS 460 cattle
CAK11130     388 kei-npgLIPHHINFSQVSPEDYqqmTNIIRGVMENDYPRlgLDNCDIKEELNKAVQGTGLAFIAFTEAMTHFPASPFWS 466 zebrafish
XP_416124    381 tgnlsqdMIPHHINFSSITAEDYnlvYDIIQKVKEEEFESlgLKSCQIEDELGKAVQGTGLAFIAFTEAMTHFPASPFWS 460 chicken
XP_003221168 381 mgnlsrdIIPAHVNFSSITAEDYnlvYDIIRKIKEEEFPLg-LKPCLIEDELDKAVQGTGLAFIAFTEAMTHFPASPFWS 459 green anole

Feature 1                                                                                        
Q9H2J7       461 VMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE 540 human
Q9XS59       461 VMFFLMLVNLGLGSMFGTIEGIITPVVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE 540 cattle
CAK11130     467 VMFFLMLVNLGLGSMFGTIQGILTPIVDTFKVRKEYLTVGCCVLAFFIGLTFVQRSGNYFVAMFDDYSATLPLLIVVLLE 546 zebrafish
XP_416124    461 VMFFLMLVNLGLGSMFGTIEGIITPIVDTFKIRKEILTVICCLVAFFIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE 540 chicken
XP_003221168 460 VMFFLMLVNLGLGSMFGTIEGITTPIVDTFKVRKEILTVTCCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE 539 green anole

Feature 1                                                                                        
Q9H2J7       541 NIAVCFVYGIDKFmEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLV 620 human
Q9XS59       541 NIAVSFVYGIDKFmEDLKDMLGFTPNRYYYYMWKYISPLMLLSLLIASIVNMGLSPPGYNAWMEDKASEKFLSYPTWGMV 620 cattle
CAK11130     547 NIAVAWVYGTDKFfEDLKDMLGFTPYRYYYYMWKFVTPVLLLGLLAASVIQLGLAPPSYSAWNQQLAKEQSLSYPPWGLA 626 zebrafish
XP_416124    541 NIAVTRIYGIEKFmEDLKDMLGFSPSQYYYYMWKYISPLVLLCLLVASIVQMGLSPPGYNAWIEDTATEEFHSYPTWGMM 620 chicken
XP_003221168 540 NIAMSYIYGIDKFmEDLKDMLGFSPNQYYYYTWKYISPVVLLSLLVASVVQMVLSPPHYSAWIEEKATEEFQNYPTWGLI 619 green anole

Feature 1                            
Q9H2J7       621 VCVSLVVFAILPVPVVFIVR 640 human
Q9XS59       621 ICISLMVLAILPIPVVFIIR 640 cattle
CAK11130     627 VCISLVVTAILPVPVVFILR 646 zebrafish
XP_416124    621 VCISLMVLAILPVPIVLIVR 640 chicken
XP_003221168 620 VCVSLIVLAMLPVPVVYVIR 639 green anole

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