1MMR,1BQQ,1B8Y


Conserved Protein Domain Family
ZnMc_MMP
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cd04278: ZnMc_MMP 
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Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).
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Statistics
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PSSM-Id: 239805
Aligned: 59 rows
Threshold Bit Score: 150.432
Created: 24-May-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active siteTIMP-binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
  • Structure:1BQQ: Human type-1 matrix metalloprotease coordinates zinc
  • Citation:PMID 9724659
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1MMR          9 KWTSKVVTYRIVSYtrd---lphITVDRLVSKALNMWGKEI--------PLHFRKVvwg--------taDIMIGFarGAH 69  human
1BQQ_M        5 KWQHNEITFCIQNYtpk---vgeYATYEAIRKAFRVWESAT--------PLRFREVpyayireghekqaDIMIFFaeGFH 73  human
AAH92954     67 RWEHFNVSYKITKFpnt---lnkDDTRKAISIAFTKWSDVS--------PLTFTEItnts------ksaDITIGFytYNH 129 zebrafish
CAB76364    170 PSSKLHLSYGFLPNy-------pIDAIKPVSRAFSKWSLNT--------HFKFSHVady-------rkaDIKISFerGEH 227 cucumber
XP_417569    97 KWDHFNLTYKILSFprnl--inaRDTRKGLAAAFRMWSEVS--------PFSFREVprh-------vpsDLKIGFysINH 159 chicken
ZP_00521661 212 SAGKVTLQYFIRSLtdq---ldpATSRSEIERALREWTRYA--------NFTFSPAlqqg------anrTIDILFarGTH 274 Solibacter usita...
AAH25719     87 RWDHFNLTYRILSFprnl--lspRETRRALAAAFRMWSDVS--------PFSFREVape-------qpsDLRIGFypINH 149 human
7504938     116 SGQSVTLKWYISDYtsd---idrLETRKVVEKAFKLWSSQSyiknekkvTLTFQEAssk-------deaDINILWaeGNH 185 Caenorhabditis e...
CAE69507     23 KWTQNKITWSFGDPyhyltprqfDGVRRTVQESFAKWAIALe------nLMEFEEIldd-------qeaNIRVFFakKNH 89  Caenorhabditis b...
AAM48565    102 KWKEKIITYGCKAVgtst-rislDDLRRTMHQAASQWSELA--------DVEIVESsvk--------npMMVISAgrENH 164 nematode

Feature 1                                                                                    ## 
1MMR         70 gd------sYPFDgp---------gNTLAHAFapg----tglGGDAHFDEDERWTdgs--------slGINFLYAATHEL 122 human
1BQQ_M       74 gd------sTPFDge---------gGFLAHAYfpg----pniGGDTHFDSAEPWTvrne------dlnGNDIFLVAVHEL 128 human
AAH92954    130 tdcwrsplhPCFDgl---------nGELAHAFlp-------pRGEIHFDNHEFWIlgksrfswkqgvwLNDLVQVAAHEI 193 zebrafish
CAB76364    228 gd------nAPFDgv---------gGVLAHAYap-------tDGRLHFDGDDAWSvga-------isgYFDVETVALHEI 278 cucumber
XP_417569   160 tdcleslihHCFDgt---------tGELAHAFfp-------pNGEIHFDDHEYWIlgntrfswkkgvwLTDLVHVAAHEI 223 chicken
ZP_00521661 275 gd------gYPFDgr---------gGTLAHTFypappnpepiAGDMHLDGDEPWAvg----------tNVDLYSVALHEA 329 Solibacter usita...
AAH25719    150 tdclvsalhHCFDgp---------tGELAHAFfp-------pHGGIHFDDSEYWVlgptryswkkgvwLTDLVHVAAHEI 213 human
7504938     186 gd------eHDFDgangkiegnkkeNVLAHTFfpgy--arplNGDIHFDDAEDWEidvdqv--ghgsnKRFFPYVLAHEI 255 Caenorhabditis e...
CAE69507     90 sc------yEEFDgk---------gGVVAHSMyp-------pFGVLHLDGDEQWYatdene--emdqrVIDLRMVLIHEI 145 Caenorhabditis b...
AAM48565    165 yp-----ctVRFDt-----------KTLAHAFfp-------tNGQIHINDRVQFAmtnyt----ermgANSLYSVVAHEM 217 nematode

Feature 1        #     #                                    
1MMR        123 GHSLGMGHSsdpNAVMYPTYgngd-pqnfKLSQDDIKGIQKLYG 165 human
1BQQ_M      129 GHALGLEHSsdpSAIMAPFYqwmd-tenfVLPDDDRRGIQQLYG 171 human
AAH92954    194 GHALGLWHSqdpNALMHPNAtyt---gqrNIAQDDIWGIQRLYG 234 zebrafish
CAB76364    279 GHILGLQHStieEAIMFPSIpeg---vtkGLHGDDIAGIKALYR 319 cucumber
XP_417569   224 GHALGLMHSqnpNALMHINAtlt---gkkTISQDEVWGIHRLYG 264 chicken
ZP_00521661 330 GHALGLGHAdlpGSVMYPYYrl-----stTLSGDDIAGIRALYG 368 Solibacter usitatus Ellin6076
AAH25719    214 GHALGLMHSqhgRALMHLNAtlr---gwkALSQDELWGLHRLYG 254 human
7504938     256 GHALGLDHSqkaDALMHPYYknvp-ineiQLDIDDKCGVIWNYG 298 Caenorhabditis elegans
CAE69507    146 GHTLGLRHSrrkASVMRKHYekpknphkiRLSKYDVRAIRELYG 189 Caenorhabditis briggsae
AAM48565    218 GHALGFSHSpdiDSVMFAYDtpr----kwKFTSMDKYNMRSYYG 257 nematode

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