1WAO_1    182 LHRKCAYQILVQVKEVLSKLSTLVEttlkE--T-EKITVC---------------------------------------- 218 human
NP_502041  36 FCAAELAELCHRARELIWSEPIFLK----L--E-APICVM---------------------------------------- 68  nematode
NP_502500  49 YTKYELMQLIESVEAALSVDDTLAK----I--S-PPVTIV---------------------------------------- 81  nematode
NP_501111  52 LSSNEVWSVCRAVIDEFKKEQNLME----V--S-APVTVI---------------------------------------- 84  nematode
YP_255542   1 MNIEETYELLEKSKDIFRQQGPFIG----EykE-DKVVFV---------------------------------------- 35  Sulfolobus acidoca...
NP_491019  50 FYPEVLKKLLQKSCEVLKQDEMVVK----V--T-GPAVIF---------------------------------------- 82  nematode
CAA73028    1 MQRELPRLLEDAVEVLRRRGPVVRL----G--A-GSVLVA---------------------------------------- 33  Pyrodictium abyssi
NP_501547  31 FSDSDILEVLKTIKEILEPLPCLIE----I--I-APVVVF---------------------------------------- 63  nematode
NP_492012  37 SPVNCQDMLKRYEIYELCLRARELF----W--T-QPLYRHvevpvtivgdihgqfedlkmmmdmngwpftedeakemckn 109 nematode
AAC45590   11 AAKEELLLLLPEIDRIFDSEPAVLR----I--DtEPVMIV---------------------------------------- 44  Methanosarcina the...

1WAO_1    219 ----GDTHGQFYDLLNIF---------------ELN-----------------------------------------G-L 237 human
NP_502041  69 ----GDIHGQFDDLLAML---------------DMNgwplssqefealkdttvrsretgkrpqsephstqpessndvK-P 128 nematode
NP_502500  82 ----GDIHGQYPDLVRVLcnqnsk----edakkKAA-----------------------------------------Y-G 111 nematode
NP_501111  85 ----GDVHGNFHDLYRALlarteqditdeqksnFST-----------------------------------------R-Q 118 nematode
YP_255542  36 ----GDTHGAINVTEYVF---------------RK------------------------------------------F-Y 53  Sulfolobus acidoca...
NP_491019  83 ----GPVYGEGDSMISLM---------------SLA-----------------------------------------KkV 102 nematode
CAA73028   34 ----GDTHGYPEVSRWVL---------------GLA-----------------------------------------D-E 52  Pyrodictium abyssi
NP_501547  64 ----GDIHGQLGDLLQFT---------------NEV-----------------------------------------G-R 82  nematode
NP_492012 110 lllkGGKDGKQTFPAVLG---------------SGT-----------------------------------------DrQ 133 nematode
AAC45590   45 ----GDIHGNLQALEYVI---------------EKR-----------------------------------------E-E 63  Methanosarcina the...

1WAO_1    238 P-------------SETNpYIFNGDFVDRGSF-SVEVILTLFGFKLLYPDH-----FHLLRGNHETDNMN--QI------ 290 human
NP_502041 129 PvaapksvnkevttGYKR-YLFLGDYVDRGPF-SMEVVILLTALKLAYPDR-----IYLLRGNHESRSVN--TS------ 193 nematode
NP_502500 112 F-------------CNSR-FVFLGDYVDRGHH-SIECISLVFALKVVYPTN-----YILLRGNHETKSIN--YT------ 163 nematode
NP_501111 119 F-------------VRDK-YVFLGNYIDKGPR-SIECICLLFAFKICFPQK-----YILLRGPHECPSVNssEF------ 172 nematode
YP_255542  54 D-------------NVDL-IVFLGDYVDREPQtGVENLSLILKKLIESDENkgktkIVVLRGNHESPLTN--FH------ 111 Sulfolobus acidoca...
NP_491019 103 P-------------PEQT-YVMLGCYLGRGFA-QIECLVFLLAYKILHPEK-----VVLLKGHHEESISI--EMlkvkew 160 nematode
CAA73028   53 L-------------GVDA-VVFLGDYVDRGPR-GVENLSLLVERLLAEPGR-----VVLLRGNHESPSMN--LY------ 104 Pyrodictium abyssi
NP_501547  83 P-------------PDFQ-YLFLGDYVDRGPN-SLEVTVWLFCMKILFSKK-----VHLLRGNHEVRRVN--TM------ 134 nematode
NP_492012 134 K-------------TQKN-YLFLGDYVDRGPY-SIEVVLMLFAMHLRWPDR-----VTLLRGNHESRPVN---------- 183 nematode
AAC45590   64 M-------------NYKN-FLFLGDYVDRGPQ-GTEALIRLFRMKLEDPDH-----IFLLRGNHETVDMN--IY------ 115 Methanosarcina the...

1WAO_1    291 ---YGFEGEVKAKY--TA----Q--------------MYELFSEVFEWLPLAQCINGKVLIMHGGLfS-------E---- 336 human
NP_502041 194 ---YGFYREVNYRY--DA----Q--------------LYECFQNMFNVFPFCAVINNTIMCMHGGI-S-------E---- 238 nematode
NP_502500 164 ---YGFREELVNRL--GPidgfE--------------IWERFNVAFSWMPLACLVGHKILCMHGGI-S-------P---- 212 nematode
NP_501111 173 ---LGVMETFSPNH--FK----K--------------IHKKFNEAFSWMPLAAVVGQKILCVHGGI-S-------P---- 217 nematode
YP_255542 112 ---YGFFEELKIKTedAE----N--------------AYEKFRDLFSYMPYSVLVNG-YLCMHGGL-PatlegdrL---- 164 Sulfolobus acidoca...
NP_491019 161 lmaRGIERDVDL-----E----E--------------CMIEMKRACSMMSAAAVIDSKILCMPGGP-G-------Pt--- 206 nematode
CAA73028  105 ---YGFRGEFAAKV--GV----E--------------HLDILHGFYSCLPYAALMGR-VLLVHGGV-P-------Crecq 152 Pyrodictium abyssi
NP_501547 135 ---YGFKEEMMRKR--NS----H--------------LWKVFNDVFAELSICASINRKILCMHGGI-S-------P---- 179 nematode
NP_492012 184 -----------------R----QygfygecvrryserIYEVFQLAFNAMPLTAIVNKRIMCMHGGI-S-------E---- 230 nematode
AAC45590  116 ---YGFFAEIGFDE--------E--------------FLFRVSQTYDKMPIAAVLSGHTFCVHGGI-N-------Gig-- 160 Methanosarcina the...

1WAO_1    337 --DGVTLDDIRKIER-N--R-QPPDSGPMCDLLWSDP-----------Q--PQNGRSIS-K-RGVS-CQFGPDVTKAFLE 394 human
NP_502041 239 --HLTSFNQFSVFKR-P--L-EIPDVGVLTDLTWADPd----------P--TEKGYKPS-A-RGAS-FVFGPPALRAFLK 297 nematode
NP_502500 213 --KLHSLKEINEIDR-P--VaEILPDSLAQDLLWADPadgqg--amtvR--STPEYVPNgV-RGLS-FIFNEAAVRDTCK 281 nematode
NP_501111 218 --RLTSWEDIRKIKR-Pl-K-DATEDPLATDLLFADTldfdl--ihipT--RKPKYEFNvI-RNMS-VMYNEAAVTQFCE 286 nematode
YP_255542 165 --GITTVEDIAKLKY-P--D-INPDDPVGLQILWNDPr----------DglLDIDFLPS-I-RGEGiYYFGERVTNEFLS 226 Sulfolobus acidoca...
NP_491019 207 -iREKGLQKLVGLKKgV--Q-AIADKKLLMEASWSVL--------------LLDDAQKD-M-HGMP-F-FTPQQATDFCK 264 nematode
CAA73028  153 ggPEEPLR-LGEIEe----R-LRGLFCRRWLLEWGDSvavqllwndprG--ELDWFAPS-LrGPGI-YYYGRLAWKGFLE 222 Pyrodictium abyssi
NP_501547 180 --KIESWDSLTGMTK-PrvH-GDCEHGLIVDLIWSDPn----------R--KDDTIQFN-KmRGIS-TLFGKSVVDNLCT 241 nematode
NP_492012 231 --ELFDLKQLDALKRp---I-DTPDIGIIADLTWADP-----------E--CEIDYYKE-SpRGAG-KIFGAKAVDEFCK 289 nematode
AAC45590  161 ------------------sI-NDIRKEKAFPYLWNDP-----------S--NHPGLTAS-RrGSTV-KEFGPDIVDGFLK 206 Methanosarcina the...

1WAO_1    395 ENNLDYIIRSHEVKA-----------EGYEVAHGG-----RCVTVFSAPNYCDQMGNKASYIHLqGSD------------ 446 human
NP_502041 298 KLDLQMVIRGHQVVE-----------DGYEFFDGR-----RLVTIFSAPNYCGQNDNTAAVFSI-DKK------------ 348 nematode
NP_502500 282 RLNINLIVRAHQMIP-----------EGFKFFADQ-----KLLTIFSAPRYMNETDNHGATLRV-ETD------------ 332 nematode
NP_501111 287 KFNLKLIIRSHMKVP-----------FGYRFFSEK-----RLITIFNSTGFQNE-SNYGAVLKI-DGN------------ 336 nematode
YP_255542 227 YNNFKGIIRGHEAV------------DGFRTNMNG-----KVITVFSSVYHGQRSGILYHDYNN-NKF------------ 276 Sulfolobus acidoca...
NP_491019 265 ANNLKCIVRGRQMVD-----------EGYLNKP-R-----EVVTLISAVAYLDNFRNHAAVLQV-DNDkgkvirykmeeg 326 nematode
CAA73028  223 ANGLELIVRAHEAVD------------AHHVWTSSgrpvhGLEHGYTMGLEELRGSVVTVFSSL-YHG------------ 277 Pyrodictium abyssi
NP_501547 242 TLAIDLIIRAHEMKEvyvfhlylssmKGHTFEFDN-----RLLTVFSAPYYSGHNSNLGSVATI-SKS------------ 303 nematode
NP_492012 290 HFQLDLIVRAHQVVQ-----------DGYEFFADR-----KLVTIFSAPFYCGQTNNIASMLNI-DKD------------ 340 nematode
AAC45590  207 TNHLKRIVRGHTALD-----------KGYRWWFDG-----KLLSLFSCPDYVG-LGNAAAFALF-EKE------------ 256 Methanosarcina the...

1WAO_1    447 LRPQFHQFTAVP 458 human
NP_502041 349 LKISINVFRPES 360 nematode
NP_502500 333 GKLNIGRFRHKK 344 nematode
NP_501111 337 AKITIISLLPQQ 348 nematode
YP_255542 277 VRIYIKMVNDQl 288 Sulfolobus acidocaldarius DSM 639
NP_491019 327 EQLSLELVKPGM 338 nematode
CAA73028  278 AGAGALLLREGE 289 Pyrodictium abyssi
NP_501547 304 LKLRIVTLKPNK 315 nematode
NP_492012 341 MVasfmlvkpvt 352 nematode
AAC45590  257 EIKLFVFGDQQE 268 Methanosarcina thermophila TM-1