2RSC,3CB7


Conserved Protein Domain Family
LYZ_C_invert

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cd16899: LYZ_C_invert 
Click on image for an interactive view with Cn3D
C-type invertebrate lysozyme
C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.
Statistics
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PSSM-Id: 381618
Aligned: 91 rows
Threshold Bit Score: 129.267
Created: 6-Sep-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: putative catalytic residues [active site], 2 residue positions
Conserved feature residue pattern:E DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Glu-35 acts as general acid catalyst in lysozyme C
  • Citation:PMID 4262748
  • Comment:Glu and Asp residues identified by comparison to canonical C-type lysozyme
  • Citation:PMID 2563161

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     #                 #                             
2RSC_A      2 KTFTRCGLVHELRkhg-feENLMRNWVCLVEHESSRDTSktnt-nrnGSKDYGLFQINDRyWCSKGas--pgKDCNVKCS 77  domestic silkworm
ABZ80664   22 KIYSRCDFAKEMKks---gVKSLAQLGTWTCIAKHESGFntna-inrKTGDYGILQISEKfWCSNSkk--agKGCNITCK 95  maize weevil
ANU06044   21 KVYTKCEFAQEMKkhgvtsHADLGTWTCIASHESAFNTKav----nsVSGDYGILQINHYyWCSTTst--pgKGCNITCA 94  red palm weevil
AIZ72681   21 KIFGRCEFVAKLRslg-ipGNQLATWTCIANFESHFDTKav----nsQTGDYGILQISEIyWCSNSnt--pgKGCHATCS 93  Harmonia axyridis
AIZ72682   21 RIYGRCEFARALAnlg-vpRNQIPTWTCIAQKESNFDTAar----nwSSGDHGILQISQIyWCTEGgg--pgKGCNTECW 93  Harmonia axyridis
AMR73377   23 KVFSPEEFGEVMRnasgvnASHIEIWKCLVKWESSFDTAah----ntKSGDHGIFQINEKwWCSPPg-----KYCQVACV 93  Nicrophorus vespil...
ACV32411  166 KIFERCELAKELKknh-lpGTQLATWMCIAKYESHYNTAai----nrQTGDHGLFQISQIyWCSNSnk--pgKGCNAKCS 238 red flour beetle
ACM24796   19 KIYDKCDLADELErkhgvlKEDVKKWVCIAQYESTFNTKahnkqnsdGSQDYGLFQLNNKyWCGNTh----kNECNMPCE 94  Japanese blue crab
ESO99527   17 YTFTKCSLASTLVsag-vaRGDVHKWVCMANAESGLRTTahnv-nrdGSADHGIFQINDYwNCDPRngrktkNGCKHPCT 94  owl limpet
C1IIX1     19 KVLGKCEFARLLEtrynlsRNDIKNWVCIAEFESSFNTAatnr-nrnRSTDYGIFQINNKyWCGSDyg---kNVCGIPCS 94  Penaeus merguiensis
Feature 1                                                          
2RSC_A     78 DLLTdDITKAAKCAKKIYKR--------HRFDAWYGWKNhCQG-SLPDISs-C 120 domestic silkworm
ABZ80664   96 SLLSkGISGDIKCAKHVFAEtkn--hnpDGFTAWVAYNK-CRG-NQLSWVkgC 144 maize weevil
ANU06044   95 SLLTdDITVDIKCALHIFSEtakg-stkNGFTAWVTYKKyCTG-DQSSWIsgC 145 red palm weevil
AIZ72681   94 QFLNdDINDDVACARHVFDEtqr--wsgNGFTAWTTYDRyCKG-NVDSFIanC 143 Harmonia axyridis
AIZ72682   94 RFRDaDIVNDVRCAQKVYNEhtr--lsgDGFNAWTTYKY-CRG-DMSQWIqgC 142 Harmonia axyridis
AMR73377   94 SLRDdDITDDIECALSVYDEher--isgNGFRAWHGYTKhCINiTTAEEPe-L 143 Nicrophorus vespilloides
ACV32411  239 DFRNnDIKDDVACVKKIYKEhqr--lsgNGFNAWVAYKKyCTG-NNDHFIkgY 288 red flour beetle
ACM24796   95 ALLDeDITDDVRCMKKIIREtekwkgkgTGLTAWVAYVNrCKDrNLDEYMadC 147 Japanese blue crab
ESO99527   95 DFENsSLSDDVRCMKTLLGWqh----hdMAKVSYGYAAR-CKG-VTASYLsgC 141 owl limpet
C1IIX1     95 DLMSdDITAALRCAETVRRAteryrgrgKGYTAWVAYNSkCKKrDLDQYMaeC 147 Penaeus merguiensis

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