Conserved Protein Domain Family
CH_SMTNL2
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cd21261: CH_SMTNL2 
calponin homology (CH) domain found in smoothelin-like protein 2
Smoothelin-like protein 2 (SMTNL2) is highly expressed in skeletal muscle and could be associated with differentiating myocytes. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409110
Aligned: 6 rows
Threshold Bit Score: 243.719
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   #                                                 # ##  ## #        #######
Q2TAL5       352 SIKQILLEWCRSKTLGYqhvDLQNFSSSWSDGMAFCALVHSFFPDAFDYNSLSPtQRQKNFELAFTMAENLAnCERLIEV 431 human
GCF45538     175 SIKQILLEWCRSKTIGYkhiDLQNFSSSWSDGMAFCALVHSFFPEEFDYNTLDPaKRKENFELAFTMAEKMAsCDRLIEV 254 Paroedura picta
XP_005987563 361 SIKQILLEWCRSKTIGYksiDIQNFSSSWSDGMAFCALIHSFFPEAFDYDSLQPsNRKHNFELAFTMAEKLAnCDRLIEV 440 coelacanth
AAH90828     384 SIKQILLEWCRSKTIGYqniDIQNFSSSWSDGMAFCALVHSFFPTEFDYNGLSPaERKHNFELAFSTAEKKAgCDRLIEV 463 zebrafish
XP_007894863 288 SIKQILLEWCRSKTIGYklvDIQNFSSSWSNGMSFCALVHSFFPEAFDYDQLDPkNRKLNFELAFSMAEKMAhCDRLIEV 367 elephant shark
OCA44362     233 SIKQILLEWCRSKTIGYkniELQNFSSSWNDGMAFCALVHSFFPEAFDYDALEPsNHKHNFEQAFSSAEKLAnCERLIEV 312 tropical clawed...

Feature 1        ##        # ## ##  ##  #   
Q2TAL5       432 EDMMVMGRKPDPMCVFTYVQSLYNHLR 458 human
GCF45538     255 EDMMVMGRKPDPMCVFTYVQSLYNHLR 281 Paroedura picta
XP_005987563 441 DDMMVMGRKPDPMCVFTYVQSLYNHLR 467 coelacanth
AAH90828     464 EDMMVMGRKPDPMCVFTYVQSLYNHLR 490 zebrafish
XP_007894863 368 EDMMVMGKKPDPMCVFTYVQSLYNHLR 394 elephant shark
OCA44362     313 EDMLMMGRKPDPMCVFTYVQSLYNHLR 339 tropical clawed frog

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