Conserved Protein Domain Family
PITH

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pfam06201: PITH 
PITH domain
This family was formerly known as DUF1000. The full-length, Txnl1, protein which is a probable component of the 26S proteasome, uses its C-terminal, PITH, domain to associate specifically with the 26S proteasome. PITH derives from proteasome-interacting thioredoxin domain.
Statistics
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PSSM-Id: 461848
Aligned: 298 rows
Threshold Bit Score: 57.609
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESS34159       56 FEHFVDWTNVHCLN------------------DScqepfpsrdwragrprKGqrF---VSS---ADDaQLIIHIPFNRKV 111 
EFA76147      991 LMSSVDLNKSFTVGvnkklstpld-----------------rvlsneiskTKhiQ---LVSd--VDQ-QMLIHIQFNKQT 1047
EGC33468      900 ILETIDFNKCYCVNidkksisattpsnsi-------vsylgrllnneappSDtdIs--IKSi--DDS-QMIINIGFTKPV 967 
Q54GU2       1056 ILQSIDFSKCGCVNidkkqisqfsgsgaata---titcwlgrvlnneissDStiF---IQS---IDDsQLIINIGFKQAV 1126 Dictyostelium...
Q4UC69         36 QERCIDLTTSTALNvldgtfgl--------------------reilfscsESrnS---MVSd--VDP-QLILKLFFREPV 89   Theileria ann...
EFC46364      495 LLAMIDLDKSLALNsdiemkrflm-----------------lssitasvsGKftStyiAKSn--IDS-EIMFDIPFKQPL 554 
XP_009031461  152 TDDLIAVEKCRVLNmapkyels---------------------nvikmgmKG--Y---IEShv---gsQMLITVMFVNKI 202 
EEA04910       33 LDYCVNVRESFLLNckgelkhil---------------------------nmennlnpICSd--VDE-QMMIKLSFEEVV 82  
XP_001027262   23 LYSVIELAGINCLNesqsgkgrs------------------vfkeedqklENgdF---VQSdepDP--EMIFIIPFTCTV 79  
EEA08251       23 LLTYIDKDSVRTLNetilgscktlfrpysdrlLE----------------TS--L---CKSq--ENDpELLVFIPFKSPC 79  
ESS34159      112 KLMGISLgihpDQv-----qHG----PS-----VIHLYKDl---PTFDFSDA---------VSVkplhtlhllpedlcRs 165 
EFA76147     1048 KLNGLKLis----------tiSkettPK-----VLKVYFNq---QSVDFSSL--------------------------Qs 1083
EGC33468      968 KLNTIHFvsedP--------SSsssvPN-----VIKIYINq--pNSIDFSNV--------------------------Ds 1006
Q54GU2       1127 KLTSIKFvsssNRv------PDrdsvPK-----VIKIYTNndqpNI-DFSVI--------------------------Es 1168 Dictyostelium...
Q4UC69         90 CIDYLILransKPenl--daSP----PK-----TLQIYSNr---PEFDFSES--------------------------Ds 129  Theileria ann...
EFC46364      555 SLCSLLIrinnS---------T----PKdlegiSIKLFIN----QTVDFVSI--------------------------Ds 591 
XP_009031461  203 NLGSFSVsapeD--------CG----PK-----LITLYYNsks--npNFKDI--------------------------Ln 237 
EEA04910       83 SITQFGIkafkQSnqgqvicSS----PK-----LVKLYVNs---PLSDFSEIedmkpcltiNFK--------------Qd 136 
XP_001027262   80 NLKSINIiakd-----------qehaPN-----ILKVYTNq---ENVDFSIS----------EN--------------Kg 116 
EEA08251       80 SIYSLNIig-----------gEngtsPN-----HIRLYINd--eSL-DFSTIen------mePI--------------Q- 119 
ESS34159      166 hdstaQSPkPgnSgSKrgssPfnsstlgpiasArnLPptAVPLP-AL--------------LFGVTSSLWLFIE-ENQGG 229 
EFA76147     1084 lkpafSFElD-----------------------------ELSCSlISdyqa------fgqtKIHQANSITLFVEsNHSSS 1128
EGC33468     1007 ikettCLN-F--E-------Spd-------qlKlcSKpyTFnp-----------------nLYKSVLDLTILIE-SNFSN 1051
Q54GU2       1169 ltpkcTIE-F-------------------------SSpsELESYsSStpfsfasgttttntNFKSVNNLTIFIE-SNFSK 1221 Dictyostelium...
Q4UC69        130 idpdqVVElVesDsET-----------------------RVKLK-GT--------------RFTHVKSLQIFIVdNSRD- 170  Theileria ann...
EFC46364      592 hkinqEFKgkd------------------lieSiqASgcELKLK-LS--------------AFQNVSKLSIIIEnQVNTS 638 
XP_009031461  238 yrhdeCFE-Y--VfKNthtfNfni-----ielAkkIL--------TAedlrrkariyftdcRSDNVQKIIIYVQ-NNQKN 300 
EEA04910      137 dtencQMK-------------------------------ILPGS-----------------KFYRVKHLTIFIQ-ENQDN 167 
XP_001027262  117 leefmLVPnL--DgTV-----------------------YQSVR-QS--------------KFQNITKLILYIAsQNTN- 155 
EEA08251      120 -----SFDlV--EdFC----G--------------VV--EYPLK-VS--------------KFKNVNLLILHFP-S-SFS 155 
ESS34159      230 --KDV-T-KISTMQVWGV 243 
EFA76147     1129 ddCK--S-IIEKILVMDS 1143
EGC33468     1052 nkNQI-S-SL--KKIILS 1065
Q54GU2       1222 nqDKV-S-IIEKIIL--S 1235 Dictyostelium discoideum AX4
Q4UC69        171 --TDQ-T-FLNELVIWGK 184  Theileria annulata
EFC46364      639 ----MqT-SVEQLVVFGN 651 
XP_009031461  301 --TNK-T-RIDALSFFMY 314 
EEA04910      168 --VDT-S-FLNYIKIMGY 181 
XP_001027262  156 ----KeTiAISYIGLKGE 169 
EEA08251      156 --SNq-T-NIYYIRICGQ 169 
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