Conserved Protein Domain Family
L_biotic_typeA
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pfam04604: L_biotic_typeA 
Type-A lantibiotic
Lantibiotics are antibiotic peptides distinguished by the presence of the rare thioether amino acids lanthionine and/or methyl-lanthionine. They are produced by Gram-positive bacteria as gene-encoded precursor peptides and undergo post-translational modification to generate the mature peptide. Based on their structural and functional features lantibiotics are currently divided into two major groups: the flexible amphiphilic type-A and the rather rigid and globular type-B. Type-A lantibiotics act primarily by pore formation in the bacterial membrane by a mechanism involving the interaction with specific docking molecules such as the membrane precursor lipid II.
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Statistics
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PSSM-Id: 368018
Aligned: 15 rows
Threshold Bit Score: 55.8673
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
E0WX65        1 MENSkvm--kdiEVANLLEEVQEDELNEVLGAKkKSGVIPTVSHDCHMNSFQFVFTCC 56  Staphylococcus simulans
WP_002995525  1 MKNSk------dILTNAIEEVSEKELMEVAGGKkGSGWFATITDDCPN----SVFVCC 48  Streptococcus pyogenes
O85355        1 MNK---------ELNALTNPIDEKELEQILGG--GNGVIKTISHECHMNTWQFIFTCC 47  Butyrivibrio fibrisolvens
P83674        1 MRN---------DVLTLTNPMEEKELEQILGG--GNGVLKTISHECNMNTWQFLFTCC 47  Mediterraneibacter gnavus
Q09I51        1 MKSTnnqsiaeiAAVNSLQEVSMEELDQIIGA--GNGVVLTLTHECNLATWTKKLKCC 56  Streptococcus salivarius
WP_002296231  1 MKQSn-------EMLELIQEVSLDELDQVIGGM-GKGAVGTISHECRYNSWAFLATCC 50  Streptococcus mutans
Q54957        1 MTKEh-------EIINSIQEVSLEELDQIIGAG-KNGVFKTISHECHLNTWAFLATCC 50  Streptococcus pyogenes serotype M49
O31051        1 MEEKmc-----lGALNALQEFQIEELDNLLGG--RGHGVNTISAECRWNSLQAIFTCC 51  Streptococcus pyogenes
2_pfamImport  1 MKNNnki---cqDALESLQELKLEEVDELLGG--AGHGVNTISAECRWNSLQAIFSCC 53 
1_pfamImport  1 MKKGtql---ylEALEALQEIKVEELDTFIGG--GGRASNTISSDCRWNSLQAIFSCC 53
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