Conserved Protein Domain Family
DUF6179

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pfam19677: DUF6179 
Family of unknown function (DUF6179)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001520) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the aurantinin B biosynthetic gene cluster from Bacillus subtilis. This family appears to be predominantly found in firmicutes.
Statistics
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PSSM-Id: 466142
Aligned: 110 rows
Threshold Bit Score: 124.956
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
SEW36379      12 IVAELTEKYTSKESTSVSYNTAKQLMNAVIYCMNEidlvnyELDSGAAKDMAVKdMTEQQDSKLAYRTGYELVVKKVFKT 91 
WP_069875747  50 LMSDNLLRYTKGKSASVKTDVGIDLYNGVVYTIDA------YFRSFNDIDDAFE-KLMTFNVSSFYHEGKNYLKKKFTQL 122 Fusibacter sp. 3D3
WP_008788742  34 ILMEKMRRYTGGDS-SLSKEKTQSLMDSILYTLSF------YMRDI-DMQNMIE-ILKTQDVVEVYKQSQYHLLQQLHHL 104 Coprobacillus c...
RHO21023      40 IIQKRVLNFNHGNSTSISFGNYTWIIEAIDYIFVH---------GYASYKNKEY-LLQTTALKDVLYTGVKVIQNEIVEI 109
OCN05309      43 ITAKLVISYNQKKSSTVSTYVYKNIYRSVIYALDH----------VQTYKDDPR-LLQADRIYEYYQQGIVILEQQMKAL 111
EOW86466      19 VI---LSRLSG--SSVLAVEDVENIEMSINFVLNK---------------------CEAGSLIERYQQGRQVLQEQVEAT 72 
OTP15707      17 LRKKMLEKMSG--TTTMPIDEAENLLQSILYVLAH---------------AERI-GKDASSVFEKFEQGKQAIKQQLAHA 78 
RDU24724      11 LLSDRVRKYTSNESSSVSYEKARQLMGSILFCMEDa-----QSCSQNNEKKLTL-FHKKMNAKEAFEVGLNKKKVKIKET 84 
WP_094377974  11 VVAKRVRKYTSNESTSVTYQTARQILSSVLYCIQEvdfdvsHATAYEKSYELSE-GNNNLTAMKAFEIGLNKKKDKIKRA 89  Lachnotalea gly...
ANU78632      11 LTAWLADKYTSKESSSVTYETAQMLMEAVLYCVQE---------YENITASALL-SEHAVKAEDAYKIGYDRVVEKVHKA 80 
SEW36379      92 KALFEEIALDFNAYRNRAYYETVMKGMPAFFLYYDPKFNPQNH--IL-TLDYPTI--KSVQ-DSC---GIDAIYEYLSYT 162
WP_069875747 123 ELSYKYLKSMHLGIAIDAYTDTIYPGLELFFKTYDCEYMPNIT--SG-MIDYPLF--YDPM-KEI---GLWYCEYYIKTL 193 Fusibacter sp. 3D3
WP_008788742 105 YLRVQELQSHKLNISLDVYQETITKGLTAFFDVYNFDYCSQDI--VL-TLDYPTC--YPLK-QV----GLEQIIEYVHYL 174 Coprobacillus c...
RHO21023     110 KDLFEKIKMQAVYFPNDFMKYLIKKEIPSILSAWNSYNFELYYsrIKeDLSYPLLdgLPVLhQMYdlkGSDLVFYYLKRV 189
OCN05309     112 QHQALQIKCERLPVENERYLDVVHRQFFTFLEGYDMTYKATLC--KE-DFDYPLLdgLALDhHMYglqGLDLACEYANRF 188
EOW86466      73 KVLYEKILIQYKSYEIEALKGSITG-FKDFFQQYDLNFGAHLV--LGvCLDYQLA--EPVDdQLYq--GIDFVWHYLTNF 145
OTP15707      79 ADVYHLVLKTNNQLPIDSYQNLLKD-FSDFFTSYDLDYAAHQT--GPlWIDYQLA--FSVDdQQLk--GVDFVSVYLENL 151
RDU24724      85 QKLFETIMKTFCTYQNQCYYDTIIKGMPGFFKTYDVEYNAQNH--IL-TLDYPLI--TAPSlNLK---GIDLIYEYLKRT 156
WP_094377974  90 KKLFASLCVRFEDYHNDCYRETIIDGMKAFFERYDVDFDATNH--LL-TLDYPLI--CEVK-NIQ---GIDLIYEYLYRT 160 Lachnotalea gly...
ANU78632      81 KEIFHDLTGDFCDYGCSNYRGTLLEGMPAFFIAYDARFRPQDH--LL-TLDYPTV--NFRG-EMC---GIDIIYQYLCDI 151
SEW36379     163 KLEQELLKAFPEEYITTLLSSYHA----DYEELFI-NVGSIVLRNIIVCMILGKNIT---NHCFEKKDAVVLKKYIESSS 234
WP_069875747 194 NLENDFCHHYDEHDLVLVVTLYANhydmAPEDLIN-NITEILIKQSIASVSLGRAVR---SLRLSHEDMLALYVLFSTH- 268 Fusibacter sp. 3D3
WP_008788742 175 EIEHDFLNCFQESDIEKVLKGYCF-----YEHGIIdNISLLFINQLLIKSLIGYNQD---FLFQNQEEINQLYQVLSSYS 246 Coprobacillus c...
RHO21023     190 DMEISFCMLFQKE-YAEFCQLFKSirniSVSEVFI-NLSEICMNQAIASYILHQRL----SLLLSETQVKYLKEKLKNTK 263
OCN05309     189 YLEQCFCNRYEAQ-MKTLVAWYERqkgvSIHVLGL-NVMELLLRQQLFACLLPHAN----QLLFSETEVRFL--VLKIQD 260
EOW86466     146 YCEMQFLNNISEAVILITLEEYSHdlgiDYRVDVN-NVYEVIFNQVFTHIFLSKSVTsntSLVLSENEASYLLA------ 218
OTP15707     152 LYENLFCQCFPKHVLKEMFDVYGKqlqmDYRTDIN-NIYDRVLFQVFGRWLTGRKQSd--SLLLTETDFQSLEIMFEYQE 228
RDU24724     157 WIEQCFLSSFSYDNILDILKNYHK----KHEELIF-NICRVVFRNAIGCVLLDKSIY---ELMIQCDERELLKRLGDSKN 228
WP_094377974 161 SLEQEFLGYFSKEEVEKILIAYHR----DYSGLII-NIASIVLRNSLGRLLTKQDLN---CLSIGEMQRIEIEELFQDKE 232 Lachnotalea gly...
ANU78632     152 VVERGLLECFPEQAVRRLLKQVQGrtgtSYMG----NLSEMVLVTAFGCMIADRRLM---ELSLSDQDIEAAEQYFSGDN 224
SEW36379     235 QEELEIKLCNLVKILVNQGYNH-NEQLYEYLKEDVKNISFELINAVEH-DCLD-IMFLL 290
WP_069875747 269 -DNPESVFTDAFYKTIERLMPS-E---KNYFSKGFPPLLTQFRVALNS-GNLS-HFFTV 320 Fusibacter sp. 3D3
WP_008788742 247 SKELYDVLYRQLQILIKSLESPyQQEILIYFTYILNDLVSYLHQHNQF-HTLK-NAVAC 303 Coprobacillus cateniformis
RHO21023     264 S--VETIVHTAMEAILSFT----DKETKEYFMMFQDIWVKNFMDFTFL----DvDILVY 312
OCN05309     261 AATCVNIAYQRFATLV-------DEATYQYSLRFQARFLLELEIGIQN-QSLD-QLIIY 310
EOW86466     219 ---HKDEIYLTLSQIN--FIKE-----NRYYRHSLKKLQTKLNHITNV-ADLS-GLLLI 265
OTP15707     229 EGQ----IGEAFKKLLVELRLP----EAAYYWHTFQLFFDRVNEAGSEaNRR--ALFIF 277
RDU24724     229 VAELEAILIEAFERMLNLHFNN-NQEYFVYFLNEIKDFAFEIKSNAEN-NHLD-KIFLG 284
WP_094377974 233 QDKIRQILNDTLQSFVMEQFKG-DICLFEYLKKDINEIAYVLMLGIKQ-HSLQ-QVLIE 288 Lachnotalea glycerini
ANU78632     225 LQKTEGKLKTLLRILAEKSG---RQEWVPYFYSLCHEYAVRIQNGIKY-GTLE-AVFFG 278
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