5DEN,1TOH,5L01


Conserved Protein Domain Family
Biopterin_H

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pfam00351: Biopterin_H 
Biopterin-dependent aromatic amino acid hydroxylase
This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.
Statistics
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PSSM-Id: 459776
Aligned: 58 rows
Threshold Bit Score: 596.441
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5DEN_A       119 PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTEEEKQTWGTVFRTLKALY 198
ESN99339       1 M-IPRTIEDLDFCNHLLNKFDPELDQKHPGFSDLVYRKRRQQIAEKAYGYKSGMSIPYIDYQEDETLTWRNVYNSLKLLY 79 
EKC34020     178 AWFPRHISELDNCTHLVTKFEPELDCDHPGFTDEEYKKRRKQIADIAFEYKHGHPIPRVQYTREEIATWGHVYKQLKELF 257
EFO26336     167 PWFPKHISDLDKCYHCVIKYEPTSDPRHPGYGDKAYIQRREQLNAIAKAYKYGEKLPDIEYTPEEHKTWEVVFNKLKSLH 246
EGT52727     182 IWFPRHISELDKCSKCITKYEPTTDPRHPGHGDKDYIARRKFLNDQALEFKFGDEISYVEYTKEEHDTWKAVYEKLGDLH 261
EDX09472     243 PWFPKHASELDNCNHLMTKYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLA 322
XP_008182999 234 PWFPRHARDLDNCNHLMTKYEPELDMNHPGFSDKVYRSRRKEIANIAFEYKFGDLIPVIEYTADEVSTWTAVFNNVLDLM 313
ANZ03350     232 PWFPRHARDLDNCNHLMTKYEPELDMAHPGFADKVYRERRRVIANIAFEYKYGDPIPYIEYTEVERATWEAVYNTVVELM 311
EFX75078     186 IWFPKHVSELDLCNHLVTRYEPDLDQGHPGFTDVVYRKRRQEIADIAFNYKHGEPIPRIKYSVEDKNTWKAVYTELMSLL 265
XP_002589286   1 PWFPKVIADLDKCHHLVTKFEPELDADHPGFSDKVYRARRKKIADAAFEYRHGQPLPVIEYTEEETETWGIVYNSLTSLY 80 
5DEN_A       199 KTHACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYT 278
ESN99339      80 KSYACQQYIDAFNELEKCKLYTDKSIPQLENVSNFLKRKTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASKPDHT 159
EKC34020     258 PTHACREHIEAFKGLEKDCGYRETNIPQLEDVSNFLKRKTGFQLRPVSGLLSARDFLASLAFRVFQCTQYVRHGSKPDHS 337
EFO26336     247 PSHTCVEYQQNFRQMELEGLLESTRIPKLSLIDRYLQSRTGFKLRPCAGLLSARDFLAGLAFRTFQTTIYIRHHGSPHHS 326
EGT52727     262 ESHTCAVYRQNLKILQKEKVLTGDKIPQIRDVNKFLQKKTGFELRPCSGLLSARDFLASLAFRVFQTTTYLRHHKSPHHS 341
EDX09472     323 PKHACAEYRAAFQKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHT 402
XP_008182999 314 PKHFCMEYRDAFKMLQDDNIFTADKIPQLKDMNEFLKKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYIRHSTSPFHT 393
ANZ03350     312 PKHFCKEYKEKFAQMEEEGIFTPKRIPQLEEVSNFLKKNTGFTLRPAAGLLTSRDFLASLAFRVFQSTQYVRHSTTPFHT 391
EFX75078     266 PKHACRQHLEAFALLEKECGYAPDNIPQLEDISHFLKRRTGFSLRPAAGLLTARDFLASLAYRVFQCTQYIRHSSSPYHS 345
XP_002589286  81 QTHSCKEHIEGLKLLEKHCGYSADEVPQLEAVSNFLKERTGWQLRPVAGLVSARDFLASLAFRVFQCTQYLRHGSKPHHS 160
5DEN_A       279 PEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKEGDSIKAYGAGLLSSFGELQYCL 358
ESN99339     160 VEPDCVHELLGHVPMLANPEFAEFSQEIGLASLGASDENIEKLSTVYWFTVEFGLCKQEGQLKAYGAGLLSAYGELKYSL 239
EKC34020     338 PEPDCVHELLGHVPMLSVPAFAQFSQEIGLASLGASDQEIEKLATLYWFTVEFGLVRQDGKLRAYGAGTLSSYGELKHAL 417
EFO26336     327 PEPDLIHEFIGHCPMFADPLIAQFSQQIGLLSLGATDEQIEQLATVYWFTVEFGLCRQNGQLKAIGAGLLSSYGELMHAC 406
EGT52727     342 PEPDLIHELLGHVPMFSDPLLAQMSQDIGLMSLGASDEHIEKLATVYWFIVEFGLCKEDGKLKAIGAGLLSAYGELMHAC 421
EDX09472     403 PEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGAGLLSSYGELLHAI 482
XP_008182999 394 PEPDYIHEVLGHMPLLADPSFAQFSQELGLASLGASDEEIEKLSTVYWFTIEFGLCKEQGEVKAYGAGLLSAYGELLHAV 473
ANZ03350     392 PEPDCIHELLGHMPLLADPAFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGMCKEHEQLKAYGAGLLSSYGELLHAI 471
EFX75078     346 PEPDAIHELLGHVPILADRNFAQFSQELGLASLGASDSDIEKFSTMYWFTVEFGLCKQKGELKAYGAGLLSSYGELQHAL 425
XP_002589286 161 PEPDCCHELLGHVPMLSDPSFAQFSQEIGLLSLGASDEDIEKLATCYWFTVEFGLCRQDNKLKAYGAGLLSSYGELEYAL 240
5DEN_A       359 SDKPKLLPLELEKTACQEYSVTEFQPLYYVAESFSDAKEKVRTFAAT-IPRPFSVRYDPYTQRVEVLDNTQQLKILADSI 437
ESN99339     240 SDNATKLIFDPEIASVQKYDDQNYQSVYFVAESFEDMKKQVKKFALT-LNQNLNVCYDPYTQTVSMIDDQFAAGKLMKDV 318
EKC34020     418 SDSPKQLPFSPTVTSVQEYTDEDLQPIYFYVESFEDMMQKMRDHVST-IKRSVDLRYDPITQSIQVIEHKDTLETLASSL 496
EFO26336     407 SDKPQHEVFNPQRAALQKYEDFDYQPLYFVADSIFDAVTKLRVFAQN-FQRPFMVTYDPYTDSVEVIRGIEDLKDGLNRF 485
EGT52727     422 SDAPEHKDFDPAVTAVQKYEDDDYQPLYFVADSIHDALSKLRKYASS-MDRPFSVVYDPFTKSIETIESSADLEKAFSRL 500
EDX09472     483 SDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVST-MSRPFEVRFNPHTERVEVLDSVDKLETLVHQM 561
XP_008182999 474 SGKPELRPFEPSITAVQPYQDQEYQPIYFVAESFEDAKDKFRKWVSS-MSRPFEVRYNPHTQRAEILDSVEQLNNLMTQL 552
ANZ03350     472 SDKPEHRPFDPSTTALQPYQDQEYQPIYYVAESFEDAKEKFRRWVST-MSRPFEVRYNPHTQEVEVLDSVDRLDNLVSHL 550
EFX75078     426 SGKPCLLPFDPIVCAVQPYQDLDYQDVYFVSESLEDALQKFRSWVAEsIRRPYEVCYNPFTQSAEIVDSITGLANVTKQV 505
XP_002589286 241 SGKPEIKNFEPEVTAVEPYDDVNYQDVYFVSDTFDKAKEQLRSYASR-IQRPFEVTYDPYTQSVEVLDSREKIQRLSEKI 319
5DEN_A       438 NSEVGILCNALQ 449
ESN99339     319 KEKVYLLSQVMS 330
EKC34020     497 RTEVRNLEKLVK 508
EFO26336     486 KGELSSFTEAVE 497
EGT52727     501 SNDLSAITHAAD 512
EDX09472     562 NTEILHLTNAIS 573
XP_008182999 553 NLEMLHLNTALN 564
ANZ03350     551 NLEMQHLTTAIN 562
EFX75078     506 QTDLSHICTALH 517
XP_002589286 320 KGDVNLLNAAMK 331
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