Conserved Protein Domain Family
DUF218

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pfam02698: DUF218 
DUF218 domain
This large family of proteins contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain (Bateman A pers. obs). The family includes SanA, which is involved in Vancomycin resistance. This protein may be involved in murein synthesis.
Statistics
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PSSM-Id: 460654
Aligned: 503 rows
Threshold Bit Score: 49.1779
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBBU:CRES_1747        119 DAIIVL-GagltgrkpSPVLARRLDRAAqvarqlEAIRPAvvagqqgV---IIVSGGq--GAD---EPCSEAEAMARYLR 189
instpast:LEPBI_II0213  32 DLIFVL----------CSHDFRVAEYAA------SLYQKN-------FashILFSGGlnff-tkhvFPNSEAESFADCAM 87 
XP_018158160           29 TAVFCL----------CSLDKRVAARAA------QLFLDG-------YgeyLIYSGGvgklt-egrftEPEAEVFAGIAG 84 
XP_013947292           30 DAIFCL----------CSLDTRIAAHAA------QLYLDG-------LapyLIYSGDsgalt-kglfsEPEAVVFAAIAR 85 
WP_014101711           43 DLAVLC-Gs-------VKTTPAIAQCGA------QLFHDG-------YtnrFIVSGRvka-----taqETEAEMMRRILI 96  Micavi...
Q89HX8                 41 DLLFMF-Gt-------REDTALRADTAA------RLWREG-------LfrwSIVSGGv--TPG---SEQSECTIIKAAMV 94  Bradyr...
CAL78767               31 DLLFVF-Gt-------RVDEELRAETAA------GLWQQG-------YfrhAIVSGGv--TPG---AVLSECALIKAAMV 84 
WP_015253867           39 DVMFVFgG----------THPGHWETAI------AAYKSG-------LaprIIITGGsgkSGGrekAEPSEVEAIAHHLL 95  Thermo...
EHQ43493               37 DLLFVF-Gsni----lhQAIGEKINNFL------RTYsf-------nT---VLLTGGianykesyyepVSESELLLRHIA 95 
jgi:Phep_1711          41 DVLFVF-G---------SNVQHREIADI------ISYmlna--elvnQ---VVITGGvanyngsfykkEAESAQIKSYIP 99 
CBBU:CRES_1747        190 T---EAQLGGAdsrweVLQEDEATSTEENLANSTRILqerragtsgtntgtpgtntanpgsrtkrddemctIVVVTSDFH 266
instpast:LEPBI_II0213  88 E---RGVPKES-----IFLEPQSTNTGENIQFSQKLLfdlgf-------------------------qcdsIIAVQKPSM 134
XP_018158160           85 K---LGVPDDK-----IIVEPRSGNTGENVRFTYDLLkqrgl-------------------------gtksFVLVQKPYM 131
XP_013947292           86 E---MGVPEDK-----IIVEPRARNTGENVRFTYALLkergl-------------------------efnkLVLVQKPYM 132
WP_014101711           97 E---HGVPDHS-----ILLENRATNTQENIVYARRMImqrgel-----------------------dqirtIITVGNVTA 145 Micavi...
Q89HX8                 95 A---AGIPADR-----ILEEHGATNTGENVIVSLPVIdaalgl-----------------------qnirsVICLGNTWT 143 Bradyr...
CAL78767               85 R---RGIPAER-----ILEEHRAMNTGENVLFALPVIdaalgl-----------------------anvrsLICLGNSWT 133
WP_015253867           96 E---AGIPREA-----LLLETRSSNSLENVRFARELFdfsr---------------------------vrsVLFVCKSHA 140 Thermo...
EHQ43493               96 KsefPQVN--------FIVENKSRNTLENVIYANELVdlss---------------------------iqnIAFFSHSYA 140
jgi:Phep_1711         100 ------IE--KypdkqIYTENKSKNIIENIVEAQKVYsfkn---------------------------irsMTFLAHSYA 144
CBBU:CRES_1747        267 VPRTR--W-HAKhaerdfpgv----ayrvvgaetPAG---A---RPAAY----------VREYV 307
instpast:LEPBI_II0213 135 TLRIQlaL-QKQwprpnfl---------itspnySLLespHskiNLFMI----------INEiv 178
XP_018158160          132 ERRTYatF-RKQwpdeatnf-------tvaspslEFEeypDadnPKELVinimvgdlvrIREYP 187
XP_013947292          133 ERRTYatF-RKQwpdeataf-------tvsspklSFDeypDasnTRELVtsimvgdlirIREYp 188
WP_014101711          146 GRRTMmtT-ARRwpevfamh------atgnkfpvAAQdfhThaeFRRTV----------LREWA 192 Micavibrio aeruginosav...
Q89HX8                144 ARRYPmtL-HRHwpevekml------ltvdsfatPRAlwhTdveFRRRV----------LHEWd 190 Bradyrhizobium japonicum
CAL78767              134 ARRYAmtV-QRHwpevekml------ltvdgfgvPRHlwhIhpeYRRRV----------LHEWd 180
WP_015253867          141 AGRQYrtLrKHLgsdlmyipat--fdtvyrgvriNRNswsDteiGRSRV----------YGEYL 192 Thermobacillus composti
EHQ43493              141 SKRSYltL-KKVcttnsfsnfpipipvnlrdqeiTQFdwfEtekGRALV----------WSEYL 193
jgi:Phep_1711         145 TTRAAlsL-KRFfpsvmlhciplplptdylkypiSRQmwwRtayGRGLV----------WGEYL 197
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