1USV,7DME,3N72


Conserved Protein Domain Family
Aha1_N
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pfam09229: Aha1_N 
Activator of Hsp90 ATPase, N-terminal
Members of this family, which are predominantly found in the protein 'Activator of Hsp90 ATPase' adopt a secondary structure consisting of an N-terminal alpha-helix leading into a four-stranded meandering antiparallel beta-sheet, followed by a C-terminal alpha-helix. The two helices are packed together, with the beta-sheet curving around them. They bind to the molecular chaperone HSP82 and stimulate its ATPase activity.
Links
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Statistics
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PSSM-Id: 462716
Aligned: 218 rows
Threshold Bit Score: 53.7099
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1USV_B        27 DkNCIGWAKEYFKQKLVgveagS-VkDKkYAKIKSVSSIEGDCEVNQRKGKVISLFDLKITVLIEGHVd--SKDGSalpF 103
1_pfamImport   1 ErDKSGWARERLKHHILtsfsfddeaeglGVKATSIVRCDGEAKVVFSRGKKRCGYDLSVKFAWA--------SGD---V 69 
XP_009390484  59 ErNLNSWASNRIKELLKsidslE-FsNGk-AYIDDVSKCSGDAFLVTVRNKKRVGYTYELTLKFKGEWliqNENKK---I 133
XP_009380721  58 ErNLNSWASNRIKELLKslgslE-FsSGk-AYIEEVTKCSGDAFLVTVRNKKRVGYTYEVTIKFKGDWliqKENKK---I 132
XP_015643464  61 EkNLNSWANGRIKDLLGsldplE-FsTGk-ASVYEVSKCSGDAFLVTVRNKKRVGYTYELGLKFKGEWlikEENKK---V 135
XP_015627033  66 EkNLNSWANSRIKEMLGsldslE-FpTGk-ASLDGVSKCIGDAFLVTVRNKKRVGYTYELSLKFKGEWlikEEKMK---V 140
EES06256      68 EkNLNSWANGRIKDLLGslgslD-FpTGk-ASIDEVSKCSGDAFQVTVRNKKRVGYNYELSLRFKGEWlikEENKK---I 142
KQJ93269      64 EkNLNSWASSRIKDLLGslealE-FpTGk-ASIDEVSKCSGDAFLVTVRNKKRVGYNYELSLRFKGEWlikEENKK---V 138
XP_002976673  67 ErNLNDWAISKLRELLLaaepiT-FgEGs-AYVTDVSRCTGDAAILTVRGKRRVDYSFDILLDFLGKIe-vGEPFQ---V 140
XP_002990463  59 EkNLNSWAIARLKEMLLalepiE-YaDGs-ARVTEVVGCSGDATVVTVRNKKRIGYSFDITLGFQGSLl-fDEFKD---L 132

1USV_B       104 EGSINVPEVAFD-SEASSYqfdISIFKe-----TSELSEAKPLIRSeLLPKLRQIFQQFGKDLlATH 164
1_pfamImport  70 SGHVELHDF--DdTSADEFeiiVTADGssq-seVAAKKAVIDKE-----PELRKLLALWKEELlQ-Q 127
XP_009390484 134 KGHLDIPEFSFGeLEDLQVe--VSLSEekd-laAKDRMQICKDLRT-FLIPIREKLMDFEQELk-DR 195
XP_009380721 133 KGHLDIPEFSFGeLEDLQIq--IRLSEdkd-lsTDDKMKICNDLRL-FLAPIRKKLEVFEQELr-DR 194
XP_015643464 136 KGYLDIPEFSFGeLEDLEVq--ISFTDikd-lsSDNKAQISKDLKS-FLAPIREKLRKFEEELk-DR 197
XP_015627033 141 KGHLDIPEFSFGeLEDLEVe--VRFTDdkg-laSDDKRQICKDLKS-FLSPIREKLRAFEEELk-DR 202
EES06256     143 KGHLDIPEFSFGeIDDLEVq--VRFSDdkg-laSEDKTRICKDLKT-FLASIQEKMRVFEEELk-GR 204
KQJ93269     139 TGHIDIPEFSFGeLDDLEVe--VKFTDsl---aSDDKMRIGKDVKS-FLSPIREKLRAFEEELk-DR 198
XP_002976673 141 EGTLSV-DTCLGdLDDLRId--VAFTEvpetlpEPEREHLRSQMSQ-FLPKIRTQLECFEKEIkELV 203
XP_002990463 133 TGTLKFLDASCGeLDDLQIe--VDFTKdeg-lpAAEKNRLAKELES-FLPRIRETLLSFEHELk-DR 194
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