1QGX


Conserved Protein Domain Family
PAP_phosphatase

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cd01517: PAP_phosphatase 
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PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine biosynthesis and provides increased salt tolerance when over-expressed. Bacterial members of this domain family may differ in their substrate specificity and dephosphorylate different targets, as the substrate binding site does not appear to be conserved in that sub-set.
Statistics
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PSSM-Id: 238775
Aligned: 31 rows
Threshold Bit Score: 211.787
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:Yeast Hal2p binds AMP, phosphate, and magnesium

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #     #                      ##        
1QGX_A        6 ELLVATQAVRKASLLTKRiqsevish----kdsttitKNDNSPVTTGDYAAQTIIINAIKSNFPddKVVGEESSSGLsda 81  baker's yeast
CAA22754     16 TGDVEEAVRKAAAQEIMPrwrrlaa------hevdqkAGPHDLVTDADRKAELYLTEVLPRLLPgsVVVGEEAVHANpas 89  Streptomyces coe...
AAD19058      5 LPNYQNIVESVVTEITTQllnyrseh----rlvpfweKSDGSFITAADYGSQYYLKQQLAKAFPniPFIGEETLYPDqdn 80  Chlamydophila pn...
NP_101932     8 IDWLASLLAEAADTEIMPrfrrlgd------gdirqkTSAADLVTEADVNAERLITTRLRQNYPsaMVVGEEACSDDpal 81  Mesorhizobium lo...
NP_354838     7 IASLANALQEAAAVEILPrfrnlge------gdvrikSEAIDLVTEADEAAERLIRARVEEIMPqaLFIGEEAVAADasl 80  Agrobacterium tu...
NP_354839    37 IEFLVSTVAAAGAQEILPrfrnlsa------gaisekTSAIDLVTEADVLAEKAITAALLERFPkaHIVGEETYEADpsv 110 Agrobacterium tu...
ZP_00092817   7 VTMLADLLRRAAKAEIVPrfrrlgs------advrskSEATDLVTEADEQAERMMKAESARLWPdaLFVGEESVAAEpal 80  Azotobacter vine...
NP_829712     1 MPSHLLDYQRVAESIVEKtiaeliryrqrlplvhfwtKPDGSFVTPADYAVQYCLQKKLSTTFPhiPFIGEEVLDPVndn 80  Chlamydophila ca...
ZP_00268668   5 PDAVTALIRAVVDAEVLPrfrnlsa------kdihtkSGPLDLVTEADLRAEAVLSEKLCALLPgsQVVGEEAVHTDpgv 78  Rhodospirillum r...
ZP_00303029   6 LDEAVAALMRDTAQRTLLkhyqqla------dhhvtaKAADDVVTIADTESEAMLAEGLARILPeaAIVGEEAAHADasv 79  Novosphingobium ...
Feature 1                                                                   #### ##             
1QGX_A       82 fvsgilneikandevynknykkddflftndqfplksledvrqiidfgnyeggrkGRFWCLDPIDGTKGFLRGe-QFAVCL 160 baker's yeast
CAA22754     90 yg-----------------------------------------------airgeAPVWIVDPVDGTRQFVRGeeGFCTLV 122 Streptomyces coe...
AAD19058     81 ekipeilkftrllts---------------------svsrddlistlvpppsptSLFWLVDPIDGTAGFIRHr-AFAVAI 138 Chlamydophila pn...
NP_101932    82 ld-----------------------------------------------glgdaDLAFVIDPVDGTFNFASGvpLFGVML 114 Mesorhizobium lo...
NP_354838    81 ls-----------------------------------------------kladaDLAVVVDPIDGTYNFASGlpLFGVMM 113 Agrobacterium tu...
NP_354839   111 ip-----------------------------------------------aladaPLAFVIDPIDGTFNYASGfpAFGTLL 143 Agrobacterium tu...
ZP_00092817  81 ld-----------------------------------------------rlkdaELAIVVDPVDGTFNFASGipAFGVMA 113 Azotobacter vine...
NP_829712    81 hkinkilefvhkldp---------------------qvtpedlletltpyqetsSLYWLVDPIDGTSGFIKNr-FFATAV 138 Chlamydophila ca...
ZP_00268668  79 lr-----------------------------------------------rlggdAPVWIIDPVDGTGNFARGddLFGCIV 111 Rhodospirillum r...
ZP_00303029  80 le------------------------------------------------hlsdSLCWIIDPLDGTNNFAVGkpPFGILL 111 Novosphingobium ...
Feature 1                                                                                       
1QGX_A      161 ALIVDGVVQLGCIGCPnlvlssygaqdlkghesfGYIFRAVRGLGAFYSPssdaeswtkihvrhlkdtkdmITLEGVEKG 240 baker's yeast
CAA22754    123 ALAHRGVVHASWTYAPa----------------gDRLATAARGGGAFLDGerlyagpp------epgrdlrVATSHPDYT 180 Streptomyces coe...
AAD19058    139 SLIYEYRPILSVMACPayn-------------qtFKLYSAAKGHGLSIVHsqnldrrfvyadrkqtkqfceASLAALNQQ 205 Chlamydophila pn...
NP_101932   115 GVVVKGETVAGIIHDPv----------------gKDWLIGAKGGGSHIRHahgslekvr----vaasapisQMTGAVSWQ 174 Mesorhizobium lo...
NP_354838   114 SVISKGETVAGLIFDPm----------------gNDWAIAEKGSGAWLCAadg----------------sqTQMSVVTAP 161 Agrobacterium tu...
NP_354839   144 AVTVKGETVAGIIHDPv----------------mGDTIVALKGEGAYLHRkngsqaklkv--tdpaplsemVGIFSWRHS 205 Agrobacterium tu...
ZP_00092817 114 SVVLAGETIAGIIYDPm----------------gDDWVMAEKGGGAWLRRpdge-------------aqrlSVAAPVALD 164 Azotobacter vine...
NP_829712   139 SLIYEDKPILAVMACPstd------------phtYKIYSAAKNHGVSLFGtaiesrrylrsgttltgrfceASLAARNQQ 206 Chlamydophila ca...
ZP_00268668 112 ALALRGETVMGWIDHCv----------------eRRTVCAVKGRGVRQGGqir----------------hlPEAPAADPA 159 Rhodospirillum r...
ZP_00303029 112 ALAEKGETVAGWIYDPl----------------tGRLCTAHRGKGAWLNGerft--------------arpSGQEPPIAA 161 Novosphingobium ...
Feature 1       #                      #                                                     ## 
1QGX_A      241 HSshdeqtai-knklnisKSLHLDs------qAKYCLLALG-----LADVYLRlpik-------------lsyqEKIWDH 295 baker's yeast
CAA22754    181 TDeqkrdll--alrtpgvAPRPCGsa-----gLEYLAVARG-----ESDATAFs-------------------wEAAWDH 229 Streptomyces coe...
AAD19058    206 HHatrklsl---glpntpSPRRVEs------qYKYALVAEG-----AVDFFIRypfi--------------dspARAWDH 257 Chlamydophila pn...
NP_101932   175 YMaepdrt-----rlacnQTKTLSqfnyrcaaHEYRLLASG-----HGHFVVYn-------------------kLMPWDH 225 Mesorhizobium lo...
NP_354838   162 HLsqmv---------giaNTGYFDve-----tRRKILMNLAd---vRLFTSYRcaaheyrlfcgghmhflmynkLMPWDH 224 Agrobacterium tu...
NP_354839   206 HEdrrpviaanlakikmsLSINCSa-------HEYWLVSAG-----KLHFIGHe-------------------nLAPWDH 254 Agrobacterium tu...
ZP_00092817 165 QMvgmastg---ylpkdrQPQILAnl----skVRFVANYRCaahehRTFAAGHvhyl-------------myykLMPWDH 224 Azotobacter vine...
NP_829712   207 HHttrllsl---slpgqpQACRVDs------qYKYAMVAEG-----AVDFFIRypfa--------------isqAKTWDH 258 Chlamydophila ca...
ZP_00268668 160 HPlaal--------rghiGGRALMta----lrPRVATITRAs---sAAHAYLAllsgqid--------favftrMKVWDH 216 Rhodospirillum r...
ZP_00303029 162 ISlvf-----------vdQEKRAAlle--hiaPHYALVDIPr---cAAEQYPRialgind--------vsvferTLAWDH 217 Novosphingobium ...
Feature 1                                                               
1QGX_A      296 AAGNVIVHEAGGIHTDAmeDVPLDFgngr-tlatKGVIASsgprelHDLVVSTSCD 350 baker's yeast
CAA22754    230 AAGLLLVEEAGGTHLTRt-GEPFRItgg----neLPFTAArda-atARQVVALLSG 279 Streptomyces coelicolor A3(2)
AAD19058    258 VPGAFLVEEAGGRVTDAl-GAPLEYrkeslvlnnHAVILAsgdqetHETTLAALQN 312 Chlamydophila pneumoniae CWL029
NP_101932   226 LAGVLIHAEAGGHAARFdgSAYLPShv------gGGLLVAp----dRESWQELRRE 271 Mesorhizobium loti MAFF303099
NP_354838   225 LAGTLISQESGAYAARLd-GSPYLPrh-----vdGGLLLAp-----DQETWELLRE 269 Agrobacterium tumefaciens str. C58
NP_354839   255 LAGVLVHQEAGGYTARFd-NTPYRPgq-----taGGILSAp-----DKESWKMLRR 299 Agrobacterium tumefaciens str. C58
ZP_00092817 225 LAGALICQEAGAYVARFdgTPYLPHhl------dGGLLIAp-----DKSSWESLRR 269 Azotobacter vinelandii
NP_829712   259 APGAFLVEESGGSVSDIf-GNPLNYrregfilenHPIILAsgneeiHRITLEALQE 313 Chlamydophila caviae GPIC
ZP_00268668 217 AAGILIHREAGGCARLIs-GEDYAPtqt----qgMPLMARne--erWGQLAGIIRQ 265 Rhodospirillum rubrum
ZP_00303029 218 AAGVLFLNESGGKAARPd-GSPYRVdrh----lePGLIGAa-----SPALFDALAE 263 Novosphingobium aromaticivorans DSM 12444

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