Conserved Protein Domain Family
cyclophilin_TLP40_like

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cd01924: cyclophilin_TLP40_like 
cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl cis- trans isomerase activity and reduced affinity for cyclosporin A. Spinach TLP40 has been shown to have a dual function as a folding catalyst and regulator of dephosphorylation.
Statistics
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PSSM-Id: 238905
Aligned: 9 rows
Threshold Bit Score: 215.385
Created: 5-Oct-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:Based on similarity to related proteins with known structure and function.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                              ##       #                               
O49939      262 NPNVDNCVFRIVLDGYNAPVTAGNFLDLVErhFYDGMEIQRRDg----FVVQTGDPEgpaegfi----------dpstek 327 spinach
P82869      280 GDQRKSATVQIVIDGYSAPLTAGNFAKLVTsgAYDGAKLNTVNq----AVITEDGSGkv--------------------e 335 thale cress
XP_482125   239 NPNLEDCVFRIVLDGYNAPVTAGNFLDLVErkFYDGMEIQRADg----FVVQTGDPEgpaegfi----------dpstgk 304 Japanese rice
AAP79162     53 GERPKTVTMELTIDGYNAPITAGRFVSLAKkgFYDDMEIQRSDg----FIVQTGDAKkk--------------------v 108 Bigelowiella natans
BAC89441     96 ELTTTQGPITIVLDGDRAPINAGNFIDLVQkgVYTGTAFNRFEk---gYLVQVSDPQgkndggyl---------dpatgk 163 Gloeobacter viol...
ZP_00325763  15 LMVIDNQIATIEINGFNAPITGGNFVDLVErnFYDGVRFHRIEngqqfSLVQGGDPFsrnpdiplellgsgdfvdpitne 94  Trichodesmium er...
ZP_00325764  97 EEAGQREKITIQLNTSSAPVTAANFADLVEknVYDSLAFHRFVe---gFVIQGGDPQgrdpdfpiedlggggyidletde 173 Trichodesmium er...
NP_489099   183 AIKTNKGDLTVVVDGYSAPVTAGNFVDLVKrgFYNGLEFTRSEe---sYVLQTGDPPgkeqgfi----------dpktgk 249 Nostoc sp. PCC 7120
AAC18971     75 SEAVDGQTIRIELNGADAPVTAGNFVDLVSrgVYDGTAFHRVIrtpepFVVQGGDPLskdsqvplnalgrggfvdpetgi 154 Synechococcus sp...
Feature 1                                                                # #              #     
O49939      328 pRTIPLEImvegekvpvygstleelglykaqtklpfnafGTMAMAREEfen-nsGSSQIFWLLkeseltpsnANILDGRY 406 spinach
P82869      336 sVSVPLEVmpsgqfeplyrtpls--vqdgelpvlplsvyGAVAMAHSEnseeysSPYQFFFYLyd-----krNSGLGGLS 408 thale cress
XP_482125   305 vRTIPLELmvdgdkapvygetleelgrykaqtklpfnafGTMAMARDEfdd-nsASSQIFWLLkeseltpsnANILDGRY 383 Japanese rice
AAP79162    109 aEQIPLEIkvetqklpiyeytlesvsrfdepvtlpfnalGTLAMSRNIddp-nsADTQIFWLLkdndmtpsgTNVLDGRF 187 Bigelowiella natans
BAC89441    164 iRRVPIEIipegasqpvygktlrqagipekifpvmrhlpGAVGLAHTEkdp-nsGSTQFYITYannemvnprGNFLDGRY 242 Gloeobacter viol...
ZP_00325763  95 fRFIPLEIkplglgqpiiynq------ivstpvelpnvaGAIGMARTEil--nsASSQFYVPLn-------dIPVLDGGY 159 Trichodesmium er...
ZP_00325764 174 kREIPLEIkiaetgeivyne-------etdeavalsheaGVIAMARTQel--dtASSQFYFALed------iSDQLDGGY 238 Trichodesmium er...
NP_489099   250 yRAIPLEIlaegdkkptygitledagryldmpvlpfssfGALAMARPEtev-dgASSQVFFFLfepeltpagRNLLDGRY 328 Nostoc sp. PCC 7120
AAC18971    155 rRDVPLEIklqgeeqpvygka-----eldpnqvvlkhdkGAIAMARSQlp--nsASSQFYFSLg-------pNDFLNGNY 220 Synechococcus sp...
Feature 1                                           
O49939      407 a------VFGYVTDNQDYLADLKVGDVIESVQAVSG 436 spinach
P82869      409 fdegqfsVFGYTIAGKDILGQIKTGDIIKSAKLIEG 444 thale cress
XP_482125   384 a------VFGYVTENEDYLADLKVGDVIESIQVVSG 413 Japanese rice
AAP79162    188 a------VFGYTTKNNDALRELRVGDKIESVRITSG 217 Bigelowiella natans
BAC89441    243 t------VFGYVVDGLTNAEKLRIGDKILSAKVVLG 272 Gloeobacter violaceus PCC 7421
ZP_00325763 160 a------VFGNVIDGLEVIRALDLGDTITAARVTQG 189 Trichodesmium erythraeum IMS101
ZP_00325764 239 a------VFGKVSDGFDFLQEIQEGDRILIARVVEG 268 Trichodesmium erythraeum IMS101
NP_489099   329 s------VFGYLIEGRDILDTLKAGDKIESATVVQG 358 Nostoc sp. PCC 7120
AAC18971    221 a------VFGQITEGLAVIDKIEMGDRIQSARVVEG 250 Synechococcus sp. PCC 7002

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