Conserved Protein Domain Family
Neprosin_AP

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pfam14365: Neprosin_AP 
Neprosin activation peptide
Pitcher plants are insectivorous and secrete a digestive fluid into the pitcher. This fluid contains a mixture of enzymes including peptidases. One of these is neprosin, characterized from the pitcher plant Nepenthes ventrata. This peptidase is of unknown catalytic type and is unaffected by standard peptidase inhibitors. Unusually, activity is directed towards prolyl bonds, but unlike most peptidase that cleave after proline, there is no restriction on sequence length or position of the proline residue. The peptidase is secreted and is presumed to possess an N-terminal activation peptide. This domain corresponds to the presumed activation peptide.
Statistics
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PSSM-Id: 464153
Aligned: 86 rows
Threshold Bit Score: 110.097
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EES14033     138 SIQSVDGDTIDCVAANEQHGLDHPLLRTHTVQTEPPEAPmwrgrgggfvvvpaaaggggaataTATATNgssssRNNDRR 217
XP_002867711  54 SFKTEQGEIFDCIDIHKQLAFDHHLLRNHSIQLKPTSVP----------------------------------------- 92 
XP_009137347  53 SFKTEHGEIFDCIDIYKQLAFDHHLLKNHTVQVKPTSVP----------------------------------------- 91 
NP_001320047  50 SFRTKHGDTLDCIDIHKQLAFNHPLLINHSIQLKPTTIP-------------------------KWTI------NNNNNS 98 
XP_018508202  50 SFQTKFGDILDCIDINKQLAFDHPMLKTHSVQLRPTNTS----------------------------------------- 88 
NP_001189558  50 SFQTKHGYILDCIDIQKQLAFDHPLLKNHSIQLKPTIIP----------------------------------------- 88 
XP_002885996  40 SFQTKHGYILDCIDIQKQLAFDHPSLKNHSIQLKPTIIP----------------------------------------- 78 
Q8GXV8        51 SFQTEHGYIFDCIDIQKQLAFDHPLLKNHSIKLKPTTIP----------------------------------------- 89  thale cress
VDC92619      38 ikSEDGDIIYCVDIYKQPAFDHPALRNHKLQMKPS----------------------------MELGSRetnspNDGSSK 89 
XP_009137348  50 SFQTEHGDILDCIDINKQLAFDHPLLKNHTIQLRPGNIP----------------------------------------- 88  field mustard
EES14033     218 -QGAWQTWHH----------------GG-HCPRGTVAIRRTTADDVLRARSISRFGRKRRH--RRnaaVAAARaanaPDV 277
XP_002867711  93 ------KWITchnnsqki-gplelqlKGiSCPHGTVIVKRTTIQDLIYSQHLKSIGFNIPR--HVlrdGNNI-------- 155
XP_009137347  92 ------KWITsknisqkl-dplqllpRGiSCPDGTVIVKRTTMQDLLNVQHLKSIGFNRHR--HVhteGNDI-------- 154
NP_001320047  99 eKGGSFPFRR----------------DGiSCPLGTVIVKRTTLEDLIQAQSLKSMGFKSSr-------YVSSK----SKN 151
XP_018508202  89 ------KWTInnnnskng-rfvpfgqDGiRCPLGTVIVKRITHEDVIQAHRLKSMGSKYSR--YVsskGNNI-------- 151
NP_001189558  89 ------KWTRdkntqkss-slpfrqdEDiSCPHGTVIIKRTTLEDLIQIQRLKYLGVKYTts-----kDKDFL------- 149
XP_002885996  79 ------KWTRdnntsqkssslpfrqaDDiSCPLGTVIIKRTTLEDLIQFQRLKSLGFKYPap-----qDGNCP------- 140
Q8GXV8        90 ------KWTKdnnashkt-sslpfrqDDiSCPVGTVIVKRIILEDLIRAQRLQSLRFNYPG--QVsakDKKI-------- 152 thale cress
VDC92619      90 lVTSQIWTQS----------------GQ-CPVGTIPIRRVSREDISRTSSPSSFGRKPPHIynTL--------------- 137
XP_009137348  89 ------KWTInnssskng-gstpfrqDGiSCPFGTVIVKRTTHEDLILSQRLKSTGSKYST--YVtskDKNI-------- 151 field mustard
EES14033     278 iTGNGHEH-AIAY 289
XP_002867711 156 -DLTGHHF-ATAD 166
XP_009137347 155 -DLTGHHF-ATID 165
NP_001320047 152 iDLSGYHF-AVAQ 163
XP_018508202 152 -DLTGYHF-AVGE 162
NP_001189558 150 -NMTGRHF-AIAE 160
XP_002885996 141 -GMNRHHF-AIAQ 151
Q8GXV8       153 -DLTGHHF-ATIS 163 thale cress
VDC92619     138 -EKAHQHKaNTNS 149
XP_009137348 152 -DLTGFHF-AMAD 162 field mustard
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