Conserved Protein Domain Family
Dehydratase_hem

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pfam13816: Dehydratase_hem 
Haem-containing dehydratase
This family includes aldoxime dehydratase, EC:4.99.1.5. This is a haem-containing enzyme, which catalyzes the dehydration of aldoximes to their corresponding nitrile. It also includes phenylacetaldoxime dehydratase, EC:4.99.1.7. This haem-containing enzyme catalyzes the dehydration of Z-phenylacetaldoxime to phenylacetonitrile. The enzyme forms an elliptic beta barrel, composed of eight beta-strands, flanked by alpha-helices.
Statistics
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PSSM-Id: 433499
Aligned: 50 rows
Threshold Bit Score: 264.519
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013940026  43 YIGIQPRHEENpakgihtelhahvtsaVQRKVGAMIEDWARQGagSLApilwEKMYVEaGYDLP-----DTEIYICYWTD 117
EGU75129      16 IFGCQYHADTPs--------------tDKLELIEKFDNLIKDAs-VPV----ERL----EQNNI-----PSRVWMAYWTS 67 
XP_011326086  16 VFGCQYHAEAPs--------------vEKTELICRFDKLIDSAa-IHV----EHL----EQNDV-----PSKIWMSYWES 67 
EKG21394      16 LFGCQYHSPQPd--------------aKKTALIQNFDRLLDRAa-AHV----ETL----EQNEPtppvgASRVWMSYWKC 72 
EME89718      16 IFGCQYHDEEPd--------------aSKSALIARFQSLLSQSpaKHV----ETL----ESDDInkdrgSSRVWMSYWFS 73 
Q0CF39        16 VFGCQYHGLQPn--------------aSKSALASEFNDLIQEAs-VPV----EVM----EHDDFeledcRSKVWMGYWKT 72  Aspergillus ter...
EKV11786      15 VFGIQYPAGNPt--------------dSQKALTGEFDGLISGHa-AHI----DTLL---QDGCAtpntgKTYVWLTYWKS 72 
Q5B890       327 VFGIQRLEANN-----------------ANLLIDAFNAVFTTNv-PII----EHLE---QDDPT-----PTRLWLTYWPS 376 Aspergillus nid...
EED48176      18 LFGVQQPDDVQs--------------pATENLIRTFSHLITGAn-CHL----DQVT---QDGIVspgigKTRIWIATWKS 75 
EEU37245      17 IYGIQYQGQSPs--------------gRQLDLIQKFDELISGQ--AHL----DRITVP-GNDGF-----ATQIWLSYW-W 69 
XP_013940026 118 KDVAEAATRSLNLRQLYSSLfPSeqevIALWRESLSVPKTRIETVYSGNDYQPGIASIPGaAQVGHKFTGYWGAARDRLP 197
EGU75129      68 PQSFKSWWESDSTKSFWGSLpDD----AGFWRESICLPATRSMH-ESTGKDPVGFGHCGE-LTPLTEKTGYWGAYRSRMT 141
XP_011326086  68 PQKFKQWWEKDDTVYFWASLpDD----AGFWRETFSLPATRAMY-EGTGKDAYGFGHCGS-LIPLTTKTGYWGAYRSRMT 141
EKG21394      73 PEDYQRWWSSLEVSDFWNSLpDD----AGFWREKLSLPHSRVMF-ESNKNTHNGYSHVGA-LVPLTEKTGYWGAYRDRLE 146
EME89718      74 PPQYESWWQSPNVADFWRNLpNA----AGFWRERFQFTSKNSMF-ESNHARPNGFSHLGS-FAPLVDNTGYWGAYRDRLD 147
Q0CF39        73 PEDYRAWWCSPKVAAFWSKLpDN----AGFWRESLRFAHSRVLF-ETNQKAPNGFAHVGS-FEPLVEKTGYWGSYRDRLE 146 Aspergillus ter...
EKV11786      73 VADYQKWWTREDVSQFWADLpLD----AGIWREVMTPSPRRSQY-ASSRVEPSGLGNLGK-PISLGEKSGYWGCYRHRKS 146
Q5B890       377 RAVFETWWNSGPVSSFWSSLpDD----AGVYREIMTVPPGRTQHGTNATERVNGMANLGI-FEDISEKSGYWGCYYDRMA 451 Aspergillus nid...
EED48176      76 IADFEAWWESDSVIKFWSSLpPD----AGMWREFVKVPYGRSQY-KATQNRQDGQGVHFA-HKP-TEKNGYWGWIRDSIR 148
EEU37245      70 PDSHTGWWSKPAVKDFWDNLpED----AGMWREVLTVSPSRVQN-ACTAELKNGLNGLGN-MEPFSDKIGYWGCIRHRIP 143
XP_013940026 198 ----ASSHDSFEP----EY--------KLGTPNFGKDTKGRVIEGEN--KVSVAHIRSGQFWERCKDDEREAYESTLEPI 259
EGU75129     142 p---DFEGDTFSSpsn---------twQPAKSMTDKIRAGRVQITKf--PDNLCIVIEGQDYSAMKEKEREYWDENFDSL 207
XP_011326086 142 p---DFEGDMFSSpip---------tyADQSVPADKIRPGRVRITDf--PDNLCMVVEGQHYADMAEREREYWNENFDGL 207
EKG21394     147 d---ATPSDRLKSpls---------kvPPAKAQMAQIRKGRVRMDSf--PDNLCVVIEGQDHRAMKSEEREHWNERFDHL 212
EME89718     148 p------NDHLASplqsVs--------TPAQISGPKIHPDRVKINTf--PENICCVIEGQDFSAMQEKELQYWSENFNEL 211
Q0CF39       147 d---ATELDKLSTpiqpPv--------LPPRKSTKNIRLGRVSMENf--PDNLCCVVEGQDYSAMGSVEHDYWMENFHNL 213 Aspergillus ter...
EKV11786     147 ----DHTSDKMVSpvqeKLvphrplhsPSAETSGPEIRPGRVHLTQf--PDNICFVVEGQDHSAITKEEQKFWLGNLDDL 220
Q5B890       452 dvtrERRNDIRSAasktPSq-------SSSALTGEKILRGRVNLNAGylPDNIAFVVEGQDHSSISSEERSHWFEHFDAA 524 Aspergillus nid...
EED48176     149 e---LSKENRMDSpllvPPi-------PERKASLKEKTLGRVTFNGf--PDNLCFNLERQDLSEMTGAERGVWFDQFDQA 216
EEU37245     144 d---ANLDDKLASsle---------emPSRVPETSDIRPGRTLVTDf--PDNICFLVEGQDHTRMSTREKDLWFEEFDEL 209
XP_013940026 260 LREGMTFLEENAEETGDIGLRFSRHMTnghsSDIDSHtsdadkfglavtkdrrrLETCSSGFFRSLKDIEAWSSKHKTHH 339
EGU75129     208 TKEWVTNVVTAGMEKGMVSARACHAFAgeksLGATNGtttngtpnggifpgldyIRQAQILYWTDLSKMEHMGRWDKGHV 287
XP_011326086 208 TKQWVTNVVTAGHEQGMVIARACHGFAgekkLGATNGpvngif------pgldyVHQAQILIWQDISKMEHLGRYDKTHV 281
EKG21394     213 TKSWVTHVVGAGADAGMVSARLCYAPHsgkvEACGDVsleqgw-----aqafsfNRRVQILYFLDLSYMERIGRNVKTHV 287
EME89718     212 TNEWVTICLEADGLDGILSSCLCHDP---------TSplippttsrrwarglkhTRRLQIFYFQDLSFMERLGKKYQAHR 282
Q0CF39       214 TTEWLTTALKAPIEDGVVSARLCHDPQsgsmDKAPAVpffna--------alnaKRKLQLLYFLDLSCMERIGRKYKSHV 285 Aspergillus ter...
EKV11786     221 VNNWIKDLIEAGPESGILDGRICYDPEggrfRDGEPNal-------------gyNKKIQLFYFQDLGQMEKIGRLNKGHV 287
Q5B890       525 VTRWIINLVAAGPEHGVLNARLCYEPVcgtyRDADGApsa-----------lnyNRKIQLFYFQDMESMERIGRENKGHV 593 Aspergillus nid...
EED48176     217 ACKWMDDLAHAAPEAGILTSRMCYDERlgtyKEGDSEfh-------------kyNRKVELFYFMDLRSMERAGRSNKGHV 283
EEU37245     210 VTGWMEHLGKDTTANGLFDVRMGHVSDcgtfKD-TGPinl------------nhNRKIEMFYWMDISKFERVGRVHRGHV 276
XP_013940026 340 KIFHGAHAHSIKFG---KTTfKFRSWHEMSTLKPGEVTYEYINCHPRTGL 386
EGU75129     288 KLRRNFMSAYGPGGv--mQGgDILLWVDLGIIKGDEIDAEYVGCYEGTGF 335
XP_011326086 282 KLRRNFMKAYGPGGe--mEGgDLLLWVDLGILKKDEIDAEYVGCYESTGF 329
EKG21394     288 ELRRKFMESYAPTGp--mSNgDLLLWVELGVLKGQDMEAEYVGCYEGTGF 335
EME89718     283 DLRKGFSKAYGPKGa--mFGgELLLWVDLGVLKAGDIEAEYVGCYEGTGF 330
Q0CF39       286 QLRRKFMQAYGPKGd--mEGgDLLLWVDLGVLKADDISAEYIGCHEGTGF 333 Aspergillus terreus NIH2624
EKV11786     288 ELRKKIFESYGPGGe--mMAgKIMLQVETTVLKSGEIDCEYVGCAEGTGF 335
Q5B890       594 NLRREFMASYAPDGpmgRLPgKLCLWVEASILKSKEIEAEYVGCVKGTGL 643 Aspergillus nidulans
EED48176     284 ALRNNILKTYGPGGi-mSECgKVALWVQTNILKAPEIDAEYVGCVPGTGs 332
EEU37245     277 KLRKRWMETYGPGGemgDGVgKINLWEETSIMKGSDIVAEYVGCREGTGF 326
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