Conserved Protein Domain Family
PBP1_ABC_sugar_binding-like

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cd19999: PBP1_ABC_sugar_binding-like 
monosaccharide ABC transporter substrate binding protein such as CUT2
Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type 1 periplasmic binding protein superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes transition from an open to a closed conformational state upon ligand binding. Members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes; however their substrate specificity is not known in detail.
Statistics
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PSSM-Id: 380654
Aligned: 15 rows
Threshold Bit Score: 392.057
Created: 26-Nov-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic transport protein receptor for L-threonic acid, a sugar acid derivative

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               # ##                                                                  
KPL83314   21 TIGISNpfvGSEWRSQMIKDFQEVNAEYmaqGITNELIIESYDtdvQGQIQQIRNLMNk-GVDAIIVNpsdaaglnAVLQ 99  Thermanaerothrix d...
OXS60499   42 IVGVSNgfiGSSWRTQMIENIEKKAEEYkrkGWISELYVQNAGqdvNNQIAQIRNMIDk-KVDLLLIDpnsesalnPVIE 120 Cohnella sp. CIP 1...
SJZ60482   45 TIGVSNgfvGSEWREQMLTTLEEAFATYqeeGVVDDLVVESADvdvNGQIQQIRNLVNs-GVDAIIVNpnsptalnEVFA 123 Marinactinospora t...
APA89474   25 DIGLSNgyfGTEWRNQMIDGANQQFQTYknkGMADKLVVQQSGantGQQIQDMRNMIRq-KVGAIMVDansatalnGVIS 103 Burkholderia spren...
SIP92350   35 VIGVSNpwvGSEWRTQMVDRVQEVAQPYireGFIKEVVVQSFDvplEGQIDQIRNLISr-GADVILVNpadanalnPVIR 113 Spirochaeta americana
EOS68897   44 NIALLDssnGNAWRAQMEAEMDEAAAQYkkeGIIQNYTVYSANddaTQQSSQLSQIITegKTDVVIINpvsatslnPVID 123 Lachnospiraceae ba...
SDN35370   40 TIGVSNgfiGNAWRAQFVADIEEVAAELkadGDVKDVIVVNSTsgaNGQISQINSLLAr-GIDALVINpvsgealkPVVA 118 Ensifer sp. YR511
SJN19177   49 VIGVANgqiGNTWRAQYIAEIEAVADELteeGVVSDLIVASTNadvSEQLSQLNDMLTr-GVDAIMVNpvsstalePFIE 127 Mycetocola rebloch...
NP_436561  27 KIGLSNgwvGSEWRTQMIDEAKAAAAEWkekGVDVEVSVQSANvdvPGQIAHIRNFIAe-GVNAIIVNpnsptafdPIFA 105 Sinorhizobium meli...
OZE21470   55 RIGYANgviGNSWRGQFVANIEDKGAQLrqsGILSELRVVNSAadiTQQISQLNNFLSs-DLDAVLIDpvsagsvqAVIP 133 Rhodococcus sp. 05...
Feature 1                 #              #  #                       #                         
KPL83314  100 EAIDAGILVVSVDqevsakgaiNVAIDQAEWARISARWLVEklggkGNVVMINGITGhpANEARVKAATEVFqq-agINI 178 Thermanaerothrix d...
OXS60499  121 EAHRKGIRVITFDqsvtspyalNVVIDQKAWGARQAQWLTEqlggtGRIVIIGGVATnpANVDRLEGMKEVLagfpgIEV 200 Cohnella sp. CIP 1...
SJZ60482  124 EAAEQGIEIIAIDqavssehvtNVVIDQGEWAAISARWLAEevgegGRIIAVNGVDGhpANEARWEGASAVFde-agVEV 202 Marinactinospora t...
APA89474  104 QAQRSKIPVVSFDqavsnpyatNVTVDHYKWGQRYAQWIAEqlhgkGNVVVLDGIPGhpAAEARKKAALDTFakypgIKV 183 Burkholderia spren...
SIP92350  114 EAVQRGIIVIATDtevsspdaiNVAIDQAEWARISARWLVDklgdqGKIVAINGISGhpANTARVRGYTEVFrdasgIEI 193 Spirochaeta americana
EOS68897  124 KAVKAGIKVIGVDsviahpdvvTIATDQYKWAQIQAEFLVEklggkGDIIIYNAMAGvpASDTREKAFDDVVakhpdIKV 203 Lachnospiraceae ba...
SDN35370  119 RAIASGVLVVVADnpldmadvlNISLDHTQYWGIETQWLVEtlngkGNIVAIEGLAGntANDWRVRARDEVLarnpdVKL 198 Ensifer sp. YR511
SJN19177  128 KAKAQGVLVVVNDnaaaydgtyFVGYPQTDYWTIQTRWLAEtlggeGSIVTVGGVAGmtADELRQQGAAAVLedfpdIDV 207 Mycetocola rebloch...
NP_436561 106 QAKEAGILVIATDaevsspdaiYVGIDQTAWGAAGAKWLAEtlggkGKVVAINGVAGhpANEMRVAGYKSVFkdhadIQV 185 Sinorhizobium meli...
OZE21470  134 RLQAAGMLVVVSNdpaptpdavNVIGDNSTWWRMQTQWLVEqlggrGKIVMVTGVPGstADVQRVKAAREVLagapgIEV 213 Rhodococcus sp. 05...
Feature 1            #                                                                        
KPL83314  179 LNSVEGKWdqATGQQKMADMLAaypniDGVWAQDGvALGALRAVQAANpakWPVMVGEARAGYLQAWkevl--qskpDFE 256 Thermanaerothrix d...
OXS60499  201 LAEENGSWdyLIARRVMADMLAsyaeiDGVLTQDSmPLGVLNAYQVAGk-kLPVVTGETWAVFLRKWkqlk---daeGFE 276 Cohnella sp. CIP 1...
SJZ60482  203 VANDFADWdqATGQQVTQNLLAshpdvDGVFVQDGmALGAFQALEAEGltdEVAITGEARVGFMKRWaeqr--eadpDYS 280 Marinactinospora t...
APA89474  184 VWSGYGEWdeAKAQSVMATVIAaqpkiDAVFTEDAmALGVLRAFENANr-rVPIMTGEAQKGFLTEWkkqr--dagnPMK 260 Burkholderia spren...
SIP92350  194 LNQVNADWdnALGQSTMQNLLAtypdiNGVWVQDGmAEGALRAIRSAGr-dDIYVTGEARVGYLNLWke-------tGID 265 Spirochaeta americana
EOS68897  204 LKKVYHGWdeGEAKQLTATMIStysniDGILNQDC-SPGIMQGFKEAGkdmPKVITSDGSITYLNMWndynlknpdkAFE 282 Lachnospiraceae ba...
SDN35370  199 LASVPGQWdqATAREAMTGLLAahdniDGVLIQEVmPEGAIRAFTASDt-aLKPLTGDYVHSYLKFWkn------tpDLT 271 Ensifer sp. YR511
SJN19177  208 LAEGEGEWsqTTAESVMSSYLSaypdiDGVLVQEVmPEGVLRAFEKAGr-dYVPTTGDYNYGFLRKWqe------qpELD 280 Mycetocola rebloch...
NP_436561 186 VNEVNANWdqAQGQQAMQNILAtypdiNGVLVQDGmAAGAWKSIMDAGkagQIAATGEIRKDFIDLWik-------eKLN 258 Sinorhizobium meli...
OZE21470  214 IASVPGFWdpAKARTAMANVLAtqsqiDGVLMQDVmAEGVIRAFQSSGrdlPRVMTGDYTAGFLRSWaa------lpDLV 287 Rhodococcus sp. 05...
Feature 1         ##                                                                          
KPL83314  257 SIGVINPPGQCATGLRVAIKLLQGkqlkdgi-----lkgaagNTLYVPIPGVvtkenFDVYYeivkdktdwytldsVMND 331 Thermanaerothrix d...
OXS60499  277 SFGQNNPPGIGVTALGIGVRLEQGkiwrepps--ggafhyevRRFVTNDNLEaeldkIKHLPdtyisdewlseqelDELF 354 Cohnella sp. CIP 1...
SJZ60482  281 SIGVPNPPSGSVSALHIAVRLLQGeefap--------dtldgNTLYLPMPETvtdenFDERFaevegeadtyavdhAITP 352 Marinactinospora t...
APA89474  261 VFVQVNPPDISRTALGIAVRLAQGrklk----------plpdNTYYFPITKTvtaenLDATLatmsdkpdsyflgqWLSE 330 Burkholderia spren...
SIP92350  266 GIGVANPPGCMASALEVAVQLLKGrelkdgv-----lsgpfgNTLYVPVPVVvtnlnFDTVYneykgypdyysvdgHITP 340 Spirochaeta americana
EOS68897  283 GIIVANPPGMGVDAIKIAIRLMHGaefkddal---kdsdggkAVLLDPDPVItnenrEEWVEkvksmdasytfstvLSDE 359 Lachnospiraceae ba...
SDN35370  272 SVVVANPPGIGADALRIATEILRGktlnaealvanpidpsykNTILVPEPYViereaNTGRPwctettkclsldeaLGML 351 Ensifer sp. YR511
SJN19177  281 SIAITNSPHIGADGVKIMVRLLQGqtfkegeltanpldpelvNAFLVPYPYVitregEQDAAwmegisptttavtlDEVI 360 Mycetocola rebloch...
NP_436561 259 SGATVNPPGVMASALNVAVLMLQGkelkepa-----kagqygNALYLPIPFIdsknvAEAAKqlegkpgyysytssLSIE 333 Sinorhizobium meli...
OZE21470  288 SIGVPYSPTNGADSIEFAVRLLQGrtirsnmlapnperedlrNAVLLAPSLAitrdgQPGPWtpegtevislddalARVD 367 Rhodococcus sp. 05...
Feature 1      
KPL83314  332 L 332 Thermanaerothrix daxensis
OXS60499  355 Q 355 Cohnella sp. CIP 111063
SJZ60482  353 E 353 Marinactinospora thermotolerans DSM 45154
APA89474  331 P 331 Burkholderia sprentiae WSM5005
SIP92350  341 A 341 Spirochaeta americana
EOS68897  360 Q 360 Lachnospiraceae bacterium 3-2
SDN35370  352 D 352 Ensifer sp. YR511
SJN19177  361 A 361 Mycetocola reblochoni REB411
NP_436561 334 E 334 Sinorhizobium meliloti 1021
OZE21470  368 G 368 Rhodococcus sp. 05-2255-1e

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