Conserved Protein Domain Family
CCDC93_CC

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pfam09762: CCDC93_CC 
CCDC93, coiled-coil domain
This is a coiled-coil domain found in CCDC93. Human CCDC93 is part of the COMMD/CCDC22/CCDC93 (CCC) complex that interacts with the multisubunit WASH complex, which is required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. The CCC complex controls Notch activation by modulating its intracellular trafficking.
Statistics
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PSSM-Id: 462886
Aligned: 33 rows
Threshold Bit Score: 132.029
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEB19635         23 IDLLLAAGYFRARIKGLSAFDKVVGGMIWSM-------DSCNFDVNVD-LLFQE------NSTIGQKIALTEKIVTVLPK 88 
1_pfamImport      1 LQALETAGFPKAHVNSYSAFDRILSGIAWLLqrivrreDAEKCRVQWD-VLYHP------HDKMKPRLELVQEVVRCVEA 73 
EEY67126         42 LQCLETAGFPKAHVNSYSAFDRVLSGITWLLqrivkreDAEKGRVQWD-VLFQS------HDKMKPRLGLAQEAVRCIEA 114
jgi:OSTLU_28290  22 TDLFVAAGCHRARFASLAPFDRVLGALAWAVra----aDGALDDVDADaL----------YATMGERLRACEAIERALRD 87 
Q00SS5           17 FELFLSAGYHRARFTDVAVFDKLLGCFVWAI----------LNSSDGDeLHGLDlsalseESSLGEKIATCERVERALRE 86  Ostreococcus...
Q4DS58           21 LQKLADGGYHRARVKALPVFDRIAGGLTWGI-------LSSRHRLHVE---FVE------NATIREKICISEKICNALKR 84  Trypanosoma ...
Q93309           23 VERLVLAGCNLNRVTTHSLQNQIMRGTISAL-------KGFQTNPKAEaLKYRNv----pSDNAKERMDQCKKVVEILVD 91  Caenorhabdit...
CAP27715         72 LNALSDAGYHRARVTSLSLYDRILGGICWAM-------SMSYPKPKGKqWWFFEevd-gaKKNDKERQAEITQMMQVKSD 143
EGT40501         92 IKQLGMIGYHRARVMQLSNYDKIVGGVACLV-------DVFRPLSPFEnWIFEEddvhgtKKAVADKRKEVEQVIGALTK 164
EFJ07491          5 EDLLVAGGYFRARISSLSPFDKLTGGLAWCI-------AASNVDVDYDhLDYSD------DLILGEKIKIGEAIESALQR 71 
EEB19635         89 M--ECPFRIEPHQIQGLDFVHIFPV---IQWLIKRSVKVreer------------------------kdfiRYHAILKY- 138
1_pfamImport     74 LdyACPVAIQPHQLLLQDFSDIKTVqklVLWLIDEGQLA--------------------------------SHCEKIRRe 121
EEY67126        115 LsyTCPVCIQPHQLLLQDFGDIETVqklVLWLIEEENET--------------------------------QHLHKIRRe 162
jgi:OSTLU_28290  88 M--GAPGALRAHQIGGLDADALLPT---ARWLITRVLETrerr------------------------krdaRARAMYAYk 138
Q00SS5           87 M--GCPHELRAHQVRGLDADAATPV---ARWLVRRVIERrelr------------------------gdrvRKFSRFVYr 137 Ostreococcus...
Q4DS58           85 M--QCPIDLRPHQIHGLDYSSLLPV---AAWLLKRVEATraen------------------------afflEKQTAWDFs 135 Trypanosoma ...
Q93309           92 V--NCPFKVEPHHLIRTDYAMLTPM---IIWVLRQTLLYeceh-------------------------nqhKKFYANFFs 141 Caenorhabdit...
CAP27715        144 I--HCNLNASNHDILNMNPQVVGPL---VDFVLARINNMvldknafftwsglfvcrydnrptfleehfyalRIFNTNQYs 218
EGT40501        165 V--GCPYSSSVNDFLNCNQAVMSQI---VSWVLPKVSRAaleksryecflstfnnpyddlqsftrdfvkglRRFNETQHf 239
EFJ07491         72 M--GCPYPLQAHQIQGLDYPAVLPV---VQWLVKRVLDTrnei------------------------gdllRRYSHFQFs 122
EEB19635        139 -------ENQIc------SKKiiSPmVTSNLLKLEDS---YRRKRLFKKLNKTSEN---EEIEVENTLLEYG 191
1_pfamImport    122 raflqimGPQK-------ERKhvTG-VKTDVERLLDV---YAPKRRWQYVAIAGKQeesEDALIQRCLLEYG 182
EEY67126        163 raylqamSPQQ-------ERKlvTP-LKKEVQFLMDA---YAPKRRWQYVAAEGEIeenEDALIQRCLLEYG 223
jgi:OSTLU_28290 139 rtc-greALGT-------ART--RErAARARRALREE---YGARRRYKRAAGKEPPrenASRWAKSVMMEYG 197
Q00SS5          138 rid-rldSLEVg------ASA--RTrATQAGR-LRDD---FGARRAFRRARGTAPPrenPARWAKSVMMEYG 196 Ostreococcus tauri
Q4DS58          136 rrfgtslQSLLs------EKEmtAQsGGDDVSLLPPTqesLCFSRR------RPAP---LRQRVSEVADRHS 192 Trypanosoma cruzi
Q93309          142 kk--fasEEKA---------------VADFLRRFREEstdIIKSTWFYQE--FKEEilgKKLSGRQILGKYL 194 Caenorhabditis elegans
CAP27715        219 dairmlkFDHS-----------------------------------------IIRD---DWVTGRQMLYEYA 246
EGT40501        240 elrrmdlFDTS-----------------------------------------IIRD---KEANGKMILTEYn 267
EFJ07491        123 kny-elpIQHRskdyndtIRAhaEDpQSGHLQHISRQ------SRNLQ----LFFD---RNIRAEYTVLKYG 180
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