6D06


Conserved Protein Domain Family
A_deamin

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pfam02137: A_deamin 
Adenosine-deaminase (editase) domain
Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defence against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc.
Statistics
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PSSM-Id: 460458
Aligned: 83 rows
Threshold Bit Score: 243.624
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6D06_A               72 SVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDdq------------krSIFQK-SERg---G 135
XP_002057463         67 ALATGTRCIGASKLCAKGFVINDSHAEVLARRAFLRYLHNQLLKANAQKDqqqd---------aaqSIFSWkSAAg---C 134
WGS:AAPU:GI19739-PA  54 ALATGTRCIGASKLCNRGYILNDCHAEVLARRAFLRYLQNELLNAMTQTGdv------------nhSVFIWkPSTg---C 118
EDW03209             56 SLATGTRCIGSSKLCARGFILNDCHAEVLARRGFLRYLNNEIMKAAMCLVgkt-----------eeSIFSWqTAEr---C 121
EDW51676             54 SLGCGTKCIGESKLCPKGLILNDSHAEVLARRGFLRFLYQELKQD---------------------RIFHWnSELs---T 109
WGS:AAPP:GF15620-PA  55 ALGLGTKCIPHTKLCENGFILNDSHAEVLARRAFQRYLYHEL-----GQD----------------RIFHWnCDSq---C 110
1_pfamImport          1 AIGSGTTCLGESQMRPDGLILHDSHAEVIARRSFIRYLYHEIKSTWNSTSs---------------TIFNKlIDg----K 61 
EFJ11931             51 ALGTGTKCLGGSQRSLAGDTINDCHAEVIARRTLLKLLYTDIGSFVDEGQds------------rsKFFKRdDNg----R 114
F4HU58               50 ALGTGTKCVSGSLLSPRGDIVNDSHAEVVARRALIRFFYSEIQRMQLTSGksneakrqridsetssILESAdSSCpgevK 129 thale cress
XP_015163430         64 SLGTGTKCIGRSRRSSKGDVVNDSHAEIIARRALLRYLYSEIQDVYNTHAhsngsvl---rddvenFMFHLeSDGlgtkK 140
6D06_A              136 FRLKENVQFHLYISTSPCGDAR-IFSPHEPiLEE------PADRHPNRKA-----------RGQLRTKIE---------- 187
XP_002057463        135 FTLNEQLEYHFLSTQTPCGDAC-IVVDSEP-SIL------PAKRSRLEP------------KAALPLATSst-------- 186
WGS:AAPU:GI19739-PA 119 FALNEQLEYHFLSTQTPCGDACiVADDACL-S--------GVPAKRSRLDlet------aqPLINKSSVY---------- 173
EDW03209            122 FTLNENLVFHFLSTQTPCGDAC-ILDESNI-DI-------DFATLPAKRK-----------RLDNDACEEv--------- 172
EDW51676            110 FDMDEHVEFHFLSTQTPCGDAC-ILEEEQS-AVQ---------------------------AKRQRLDEDsem------- 153
WGS:AAPP:GF15620-PA 111 YDLDDHVEYHFLSTQTPCGDAC-IVVEEDP-ERA---------------------------KKRPRLSEEsdv------- 154
1_pfamImport         62 CCLKPGISFHFYTSNTPCGDAT-IFPVTVN-QTTp-----VNQTHPVNGTttvnqttpvnqTHPVNQTQPanqttpvnqt 134
EFJ11931            115 LRMRPEIRLHLYISQSPCGDAC-ILGVDPG-AGE---------------------------DDHSEFCCT---------- 155
F4HU58              130 YKLKSGCLLHLYISQLPCGYAStSSPLYAL-K--------KIPSTQV--------------DDSLLVQASdi-------- 178 thale cress
XP_015163430        141 LKMKHGWQLHLYISQLPCGVAS-PGSELAL-LHDspakngDMMCSSMQLSy---------sKGESSGYTA---------- 199
6D06_A              188 -------------------------------------------------------------SGYGTIPVRSNa--sIQTW 204
XP_002057463        187 -----------------------------------------------------------vfTGAKLICQQKDqcddMLQT 207
WGS:AAPU:GI19739-PA 174 -------------------------------------------------------------TGAKLINRPT-----NPLF 187
EDW03209            173 ------------------------------------------------------------fTGAKLISSNVSn---VDQC 189
EDW51676            154 -----------------------------------------------------------vyTGAKLINDLSDd--pMLQT 172
WGS:AAPP:GF15620-PA 155 -----------------------------------------------------------ifTGAKLINKDIEs---KEAC 172
1_pfamImport        135 tpvnqthpvnqthpvnqthfvnqmkinqnkhklpipdtvaakklcpdiqlgannshydvnrTGAKCLAGEPQ----DLHV 210
EFJ11931            156 -------------------------------------------------------------TGAKLVSTQVHs---EQSL 171
F4HU58              179 -----------------------------------------------------------csSRHSDVPEIG-----SNSN 194 thale cress
XP_015163430        200 -------------------------------------------------------------MNDGCLPIPFGt---VMRK 215
6D06_A              205 DG----------VLQGE--RLLTMSCSDKIARWNVVGIQGSLLSIFV-EPIYFSSIIL--GSLYHG--------DHLSRA 261
XP_002057463        208 PAal-------rTKPGRgeRTLSMSCSDKLSRWNVMGVQGALLDMLIdKPIYFSSLNF---CCAEAr------lESLQRA 271
WGS:AAPU:GI19739-PA 188 DDmlqtp-aqlrTKPGRgeRTLSMSCSDKLARWNVLGVQGALLDMVIdKPIYFISYNF---CCTEAn------pESLERA 257
EDW03209            190 DAmlqtp-aalrTKPGRgeRTLSMSCSDKLSRWNVLGVQGALLDMLLnKPIYFTSFNF---CCADAh------lKSLQRA 259
EDW51676            173 PGal-------rTKPGRgeRTLSMSCSDKIARWNVLGVQGALLDTLIsKPIYFSSLNF---CCDDAq------lESLERA 236
WGS:AAPP:GF15620-PA 173 IDamqqtpgalrTKPGRgiPTLSMSCSDKLSRWNVLGVQGALLDSLIsKPIYFSTLNF---CCADAh------fESLNRA 243
1_pfamImport        211 IGsnfhcvgclrTKPGRgeATASMSCSDKILRWNITGWQGGLVSTLVsTPVYMRSIVV--GGMADI--------QALRRA 280
EFJ11931            172 QTtgm-----lrRKPGRgdATFSMSCSDKIARWNVLGVQGALLSLFLnEPVYISTITVarSTKASPlvsdlaciEALQRA 246
F4HU58              195 KGngsqvadmvqRKPGRgeTTLSVSCSDKIARWNVLGVQGALLYQVL-QPVYISTITVg-QSLHSPdnf--slaDHLRRS 270 thale cress
XP_015163430        216 PG--------------RgdTTLSVSCSDKIARWNVVGVQGALLSYFL-EPIYIFSVTIgqSHLASKtsi---ieDEVMRA 277
6D06_A              262 MYQR--ISNIED-LPPL--YTLNKPLLS--GIsnaearqpgkapnfsvnwtv----------------gdsaievinatt 318
XP_002057463        272 VYQR--WRGRNCsLGR---YQPQKPCIRidNRlkfehaqyaerqpaptsliwaqlpes----lrpyeiavdgkrqgvtkq 342
WGS:AAPU:GI19739-PA 258 IYRR--WQGRECnLKR---YQPQQPCIRvdKNltfelaqrmdwqpapssliwalvpel----lrpfeiavngkrqgvtkq 328
EDW03209            260 LYQR--WNGRSC-KASR--YQAQVPHIRidNTltfehrqradwhpapnsliwvllpes----lrpyevavngkrqgvtkk 330
EDW51676            237 IFKRfeCRSFKH--PR---FQPQKPHIRidPCirfefsqrsdwqpspngliwsqvpee----lrpyeisvngkrqgvtkk 307
WGS:AAPP:GF15620-PA 244 IYKR--WEGRNFsHPR---FQPQKPTIRisTDisfefaqcaewqpspnglvwsllpen----kkpyeisvngkrqgltkk 314
1_pfamImport        281 FYGR--MDLNSLdFLHHtrYHLHLPIIQ--RTdskfkfykssldrnelkpngsalswckvpcnglevaaksgfrlgtvkk 356
EFJ11931            247 TFGR--LCSVARnLEAP--YRLNQPVIWlaPTppedymlypsglacgysiswdssgs------hevvigttgrkqgaagk 316
F4HU58              271 LYER--ILPLSDeLLTS--FRLNKPLFFvaPVppsefqhsetaqatltcgyslcwnys---glhevilgttgrkqgtsak 343 thale cress
XP_015163430        278 IHER--VLPLSNkLMDP--FRVNKPLVFvaPIpseefqhsetalttltcgysicwnns---glhevilgttgrkqgtsak 350
6D06_A              319 gkdelgrASRLCKHALYCRWMRVHGKVPSHLLRSKI--------TkpnvYHESKLAAKEYQAAKARLFtaf-ikAGLGAW 389
XP_002057463        343 klntvqaALAVSKYRLLLNFLDLLHCCQELREKFGLhltdlqtiS----YAECKALAKDYQLA---WRql--kcEYFKQW 413
WGS:AAPU:GI19739-PA 329 rlntmqaALEVSKYKLFINFMDLLSGCSEVREKLGLkleevkylS----YSELKALSKDYQLA---WQql--ksEYFKLW 399
EDW03209            331 kldtpqaALDVSKYKLLLNFLNLLNGCAELRQKLCLqlsdvqnlS----YAQCKALAKDYQLV---WQql--kcDYFQQW 401
EDW51676            308 kmntsqaALTISKYKLFLTFLELVKFNPKLSEKFDQplfdperiT----YASCKNLARDYQFA---WRei--keKYFLQW 378
WGS:AAPP:GF15620-PA 315 kinspqaALEISKFKLFLTFLDCISTNPDLSEKFRRkctnldeiT----YATCKSWSTVYQEA---WLql--kdEFFLNW 385
1_pfamImport        357 hegkprsSTFISRWNLFRMFKEVMEVIPDCELKSDFqal--evkS----YRNCKLLAKDYFNT---WSdv--kdKVLGNW 425
EFJ11931            317 gallpatESKLNRKSLGRSFRHLLTHFFPGLACS----------N----YLECKKLALTYLEA---KEillhlnSPFAGW 379
F4HU58              344 galypstQSSICKQRLLELFLKETHGHKRESSKSKK--------S----YRELKNKATEYYLMSKIFKg----kYPFNNW 407 thale cress
XP_015163430        351 gamspstESSLCKKRFLESFLSLSHNCVGEHAFVGN--------S----YRELKDKSQEYNLASETFKg----sSNFKNW 414
6D06_A              390 VEKP 393
XP_002057463        414 TCKP 417
WGS:AAPU:GI19739-PA 400 TTKP 403
EDW03209            402 TCKP 405
EDW51676            379 TKKP 382
WGS:AAPP:GF15620-PA 386 TTKP 389
1_pfamImport        426 ATHS 429
EFJ11931            380 LSNT 383
F4HU58              408 LRKP 411 thale cress
XP_015163430        415 FLKP 418
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