Conserved Protein Domain Family
Gcd10p

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pfam04189: Gcd10p 
Gcd10p family
eIF-3 is a multi-subunit complex that stimulates translation initiation in vitro at several different steps. This family corresponds to the gamma subunit if eIF3. The Yeast protein Gcd10p has also been shown to be part of a complex with the methyltransferase Gcd14p that is involved in modifying tRNA.
Statistics
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PSSM-Id: 461216
Aligned: 95 rows
Threshold Bit Score: 178.906
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERT03134       4 VIQPNAWIGLK-LPSE-NVRFLRIAPNTTISLGKYGSFPSNLIIHRPYHLTYELLDKRDDEPFSrlrVIptDELYADVFA 81 
NP_001026212  10 RICEGDCAVLK---RGdVFKAVAVLRQRKIIFEKQG-FYLDNAIGHVYGTTFEVTSDGNLQPKR--------QVEETTTE 77 
XP_005805701  12 RIKEGDHIVLK---RGdVYKAVQIQRKKKVIFEKQW-ILLDNVVGHLYGTTFEIASGGTLQPKE-------DKETGSSTD 80 
XP_007229761  15 RICEGEYVVLK--RGE-VYKSVQVEKRKKVIFEKQW-IFMDNAVGQLYGSTFEVDSGG---------IL---NLRKPKQD 78 
NP_001032469  13 RIAYGDYVVLK---RGeVFKSVQVENKKKVIFEKQW-FFMDNAVGQLYGTMFEIVAGGSLKHKP-------VKRAGDSLD 81 
1_pfamImport   1 FISLNKTVILD---KNgILKAVKLIPNKMIVFEKLR-FKPDKAEGMNFGTIFKgg---------------yITTDVDSLD 61 
XP_015795927  16 M---GDYVILTtLLGKkVFRLAKVEETGDVYFKKER-INLKTLIGAQYNSIHRLDRSTRTLKHAgl----tQEQLREILD 87 
Q4CWY5        17 RIALGDHVIIT---GGgVKRMALVQAGNKLRLGSSGVVQLEKLVGLRFGEVLRYDPKDRVLLPTna----yPDLDITSLQ 89  Trypanosoma cruzi
XP_011264922   9 VITVGIHVIVK---KQsFSKVYKVSENGTLMLGKNQKVEMHEIIGKPFWSTFEMVPKHGSKNTYslklvertes------ 79 
XP_001952015   9 IIARGHYLIIN---KNeTYLIHQISNKAILKLGRDV-IDLKAAIGQPFSSTYKLEPMPEKKRHYslvicndnqv------ 78 
ERT03134      82 DEAQAAASAmdaargrtgdeadadgevengvdgggdgdfpglgddagtssveytlvdmesqavIARSNR-ATID-ADARQ 159
NP_001026212  78 TKEA------------------------------------------------------------GTDNR-NIVD-DGKSQ 95 
XP_005805701  81 VKVA------------------------------------------------------------GTDNR-NIVD-DGKSQ 98 
XP_007229761  79 EDSTDNKEA-------------------------------------------------------GLDNR-HIVD-DGKSQ 101
NP_001032469  82 SKEA------------------------------------------------------------GQDNR-HIVD-DGRSQ 99 
1_pfamImport  62 THADDAQ---------------------------------------------------------GKDNRlSLIDtHGKSQ 84 
XP_015795927  88 VSFTFTELNvd---------------------------------------------------dESKDNR-LIND-DGLAQ 114
Q4CWY5        90 QRLED-----------------------------------------------------------ARDNR-HLVD-DNRNQ 108 Trypanosoma cruzi
XP_011264922  80 -------------------------------------------------------wddlkgelsGQDNR-FITD-DGTSQ 102
XP_001952015  79 -------------------------------------------------------rnqwstngcGTDNK-LITD-DSSSQ 101
ERT03134     160 TLTTDEIEALKRE-GTGaGRDLIAKLLLSHAALDQKTAFSLAKYKLLKTKKYIRRFTVLPLDVYTLGNWLLDD-K----D 233
NP_001026212  96 KLTHDDIKALKDK-GIK-GQEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAVITIVKPSTRILSTMYYA--R----E 167
XP_005805701  99 KLTRDDIETMKEQ-GLK-NEEIIQQLIDNSSTFNNKTGYAQDKYIKKKKKKYENTVTVLKPTCRIIAMMYHG--R----E 170
XP_007229761 102 KLTRDDIESLKEQ-GLK-GQEIIQQLIDNSTTFKDKTEFAQEKYIKKKKKKYESNVTVLKPSCRILAMMYHG--R----E 173
NP_001032469 100 KLTRDDIETLKEQ-GLK-GQEIVQQLIDNSTTFKDKTEFAQEKYIKKKKKKYESDITVLKPSTRLLAMMYHG--R----E 171
1_pfamImport  85 SIKRENIIEMKDE-GFT-GEEIVQRLVENSASFADKTAFSQNKYLKKKKKKYLSYVRVHKPNARLITQLYQE--R----E 156
XP_015795927 115 KLDRDDIESLKNQ-GMS-GDVIIKTLVENSNTFKERNVFSQEKYLKKKQAKYSNLIRVLKPNPTLLTEMYYS--Q----G 186
Q4CWY5       109 ILSNVEIASLRQEkGVD---AFLTTLVQKSTTFHTKTAYSQEKYLRKKKKRYGTLYKVERVTPDAAAEIYLPTiNpsdvE 185 Trypanosoma cruzi
XP_011264922 103 RLSKEEILQLQES-GKS-GKEIIGSLIENSTSFVAKTEYSQEKYIKKKERKYFKFLTIYRPTILSLHEVYFR--Q----N 174
XP_001952015 102 LLSTDEIIALKES-GES-GQNIVERLLENSKTFQLKTEYAQEKYLKKKARKYCDYLTIFKPSIRLITDVLYK--Q----Q 173
ERT03134     234 VGnKI-MDLRDEMVALLGCWANVHYGGpsrylqappamppaetaetaasktgdgeetvmvdaqplvpdaqaeevataaaa 312
NP_001026212 168 PG-KI-IHLRYDTLAQMLTLGNVRAGN----------------------------------------------------- 192
XP_005805701 171 PG-KI-CHLRYDTLAQMLTLGNIHAGS----------------------------------------------------- 195
XP_007229761 174 PG-KI-CHLRYDTLAHMLTMGNIHAGS----------------------------------------------------- 198
NP_001032469 172 PG-KI-CHLRYDTLAQMLTLGNIHAGS----------------------------------------------------- 196
1_pfamImport 157 PA-KI-CNIRIDTISQILTAANIRHGA----------------------------------------------------- 181
XP_015795927 187 PM-KI-NNLRIDSLAQMLTACNVRSGA----------------------------------------------------- 211
Q4CWY5       186 PEeTRsMRLRADTLALILHHSDVHSGS----------------------------------------------------- 212 Trypanosoma cruzi
XP_011264922 175 HD-KI-GGLRMDSLAQILSYSDVQADG----------------------------------------------------- 199
XP_001952015 174 TLpKT-IALRFDTLAQILCRVNLDPGG----------------------------------------------------- 199
ERT03134     313 dedeslleqppnllpddigsflgggRWLAVDD-TGGLLIAALAERMGIltnpeedddvedeqketkkettdantglgtsd 391
NP_001026212 193 -------------------------KMIVMET-CAGLVLGAVMERMGG-------------------------------- 214
XP_005805701 196 -------------------------KVLVFET-CAGLVLGAIMERMGG-------------------------------- 217
XP_007229761 199 -------------------------KIIVFET-CAGLVLGSVMERMGG-------------------------------- 220
NP_001032469 197 -------------------------KIIVFET-CAGLVLGSVMERMGG-------------------------------- 218
1_pfamImport 182 -------------------------NVAVVET-CSGVVLGAVLERLGG-------------------------------- 203
XP_015795927 212 -------------------------KFMVVDT-NMGLLTAAIIDRLAGhssmf--------------------------- 238
Q4CWY5       213 -------------------------RVLVYEK-TNGHLAAALLTRLGN-------------------------------- 234 Trypanosoma cruzi
XP_011264922 200 -------------------------LHMLYDSgCQGLPAAAMLNRIGE-------------------------------- 222
XP_001952015 200 -------------------------KYLLYENgSQGLLQAALLNQLHD-------------------------------- 222
ERT03134     392 dkdgvpedadatagddagsaeedaaqhdllerrpkrpakrarddfhvsfSLANTITLLHSNNQ-ANLT---YLKYFGYDy 467
NP_001026212 215 ---------------------------------------------------YGSIIQMYPGGG-PIRA---ATSCFGF-- 237
XP_005805701 218 ---------------------------------------------------YGSVIQMYPGGG-PVRA---GVECFGF-- 240
XP_007229761 221 ---------------------------------------------------HGSVVQMYPGGG-PVRA---GMESFGF-- 243
NP_001032469 219 ---------------------------------------------------FGSVIQMFPGGG-PTRA---GMESFGF-- 241
1_pfamImport 204 ---------------------------------------------------NGCVVNLHNGEApPNLF---AVSHFNF-- 227
XP_015795927 239 --------------------------------------------tssasRDYGECIQIYLDDA-PVSSwrqSVDALNL-- 271
Q4CWY5       235 ---------------------------------------------------DGVIMQVMDKVAqPNVF---LAQAMGLTr 260 Trypanosoma cruzi
XP_011264922 223 -------------------------------------------------NTGGYLINFHPGNV-PQIA---IVQAMNF-- 247
XP_001952015 223 ---------------------------------------------------NGCLVHIFSSTSeQNALr--AVKAMNF-- 247
ERT03134     468 adphhPPHPLNDH--LLCLSWLQLLE--------------PESDTVYAQAPP--IQPADVVASWK 514
NP_001026212 238 -----PKPFFN-----------NLHEfplskvdsllcgtlSMETLPSEPEDTalTEEETNGLVDE 286
XP_005805701 241 -----PAHFHD-----------MLHEfpicrvnallastlDTSAKDPTAEEKslNAAAEQEQIQP 289
XP_007229761 244 -----PSHFHETLh-EFPLCKVNALL--------------SGTLNLDEKDMD--SQSNDSADKEK 286
NP_001032469 242 -----PSHFHQ-----------TLHEfplckvnavlagklDLSEKDTENSRSeeTAAEKNSEAQS 290
1_pfamImport 228 -----PDSYWDD----------NLHSvplhklgpllakrsFEDEFPDEQTSKrkTSEISEVTMDI 277
XP_015795927 272 -----SPAVIDRC--LSAINIKKLYKwefd------ndtkPKDELDTEIETKe-DITPIEPKEVD 322
Q4CWY5       261 v--------------------rELWKaiprndaflfgregTEEEQNPGDEKKktGTGKNNTNKGN 305 Trypanosoma cruzi
XP_011264922 248 -----PQELKDRHiaVNIYSFLRLH---------------YQGESSVLDNISskKITDHIKETQN 292
XP_001952015 248 -----SETKIKQ---MLTVSLDEILN--------------TKNEDNIPAEKDeeDVPNCSDEKKR 290
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