1ZHI,2FL7


Conserved Protein Domain Family
BAH_Orc1p_Yeast

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cd04720: BAH_Orc1p_Yeast 
Click on image for an interactive view with Cn3D
BAH, or Bromo Adjacent Homology domain, as present in Orc1p, which again is part of the Saccharomyces cerevisiae Sir1-origin recognition complex, and as present in Sir3p. The Orc1p BAH doman functions in epigenetic silencing. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.
Statistics
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PSSM-Id: 240071
Aligned: 12 rows
Threshold Bit Score: 158.734
Created: 18-Sep-2006
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
Sir1p binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Sir1p binding site
Evidence:
  • Structure:1ZHI_A (Saccharomyces cerevisiae): interface with the ORC interaction region (OIC; 1ZHI_B) of Sir1p, defined using 3.5 A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                             #      ##
1ZHI_A      11 LKDLQGWEIITTDEQGniidggqkr---------------lrrrgaktEHYLKRSsDGIKLGRGDSVVMHNEAa----GT 71   baker's yeast
2FL7_A       8 LKDLDGWQVIITDDQGrviddnnrr---------------rsrkrggeNVFLKRIsDGLSFGKGESVIFNDNVt----ET 68   baker's yeast
AAS52816     5 LADFKGWQIIVTDESGsvikdtgrr--------------rrrrgdskeIVRLQRKsDGLQLSCADSIVCKDPQt----NS 66   Ashbya gossypii ...
6093623      2 NKLPKGWNFTIVDDNAdstnseniqgkrprrsrtsvqrsdgaspiirdNIVLIRTdDNEEFKVGDTIEITQGKgp-edPT 80   Candida albicans
CAH02150     6 AEFEVQWEIQKTDLKGnliaetprrr-------------rrgdateheVINLVRY-DGVRLYPGVTIVCKVEGa----DE 67   Kluyveromyces la...
CAG62232     5 QKELNGWQILVLDEKDelidyfeqkrpr--------rrrgaverlgkdQIFLKQGdEGMLLSVGDTIVVKEDI-----KS 71   Candida glabrata...
XP_502645    8 IYSPEAKSAPKNKKKA--------------------------------AVRAIRDqDNVEISAGDVVLLKDDPd---vEG 52   Yarrowia lipolyt...
CAE76259    30 GTDDLPWEWIYDREEDegenevipasgpg-------srkrkrttqperKIIGAQM-GDFDCYVGDTLLLKAEGs----NE 97   Neurospora crassa
EAS27777    33 GCEDLPWEWIYDCSFPvsgleqhqedatrkk---kgkqsnsapaqaprKIIGARM-GSFECRLGQTVLLKSPEa----GK 104  Coccidioides imm...
CAG62355     5 IKDLEGWQIIIKDQDGnvmderdrk--------------vrrkrnvstDLFIFREkDALTFGRGQNVVVHDEVs----DS 66   Candida glabrata...
CAG87030     5 QRDLKGWQYFLDDAELnntdsvngepttp------srrsrrgkstssqKISLKREeDELEIKEGDFLLVQQDN-----NS 73   Debaryomyces han...
EAU91735    61 REDVHGEDAEAEEDNGegssrrgkkgeetvfy-asftmkkqrprqrgrGDNSARD-AAQVYRPGDTILVETDVlyrqkRP 138  Coprinopsis cine...
Feature 1                                           #                                          
1ZHI_A      72 YSVYMIQELRLNTl----------nNVVELWALTYLRWFEVNPLAHYRQFNpdanilnrplny-------ynklfsetan 134  baker's yeast
2FL7_A      69 YSVYLIHEIRLNTl----------nNVVEIWVFSYLRWFELKPKLYYEQFRpdlikedhplef-------ykdkffnevn 131  baker's yeast
AAS52816    67 LSIYMIHEIRLNTa----------sNYVELWCFGYLCWYEINPEEYYAQFLpealdscpdslssveradyfrekfqlecn 136  Ashbya gossypii ...
6093623     81 TEYGLITEIKFGNs-----------EFIEVIVDWFIRSSEIVGMPNDFFAD----------------------------- 120  Candida albicans
CAH02150    68 LSAYMIHEVRLNTs-----------NYVELWCLNYLSWYEINAAERYKQLDgefyetnkekgdk-----ffeetfasqsi 131  Kluyveromyces la...
CAG62232    72 NGIYLIQDLRLNTp----------gNLIEIWAFVLLGRDEIDARSYLQEILpefvkdngdeds-------itekyknlvh 134  Candida glabrata...
XP_502645   53 KEFALIQGLKHGDq----------gLEAKCVLMKLFNDAEALTPKHVIPNTnknr----------------------ysk 100  Yarrowia lipolyt...
CAE76259    98 AWVGIVSEFLVDD------------GEKSAKFMWFSSEKEIRNGPKKRTDFv---------------------------- 137  Neurospora crassa
EAS27777   105 DWAGIICEFLEEEaeengrsidqtcPLKAANIMWFASPDEFLSTRKKKRSDal--------------------------- 157  Coccidioides imm...
CAG62355    67 YAVYLIHEIRQNTl----------nHALEILCFTYLRWFELEPRDYYKEFKpeylsmtnqqi---------tekfleeid 127  Candida glabrata...
CAG87030    74 PEVAIVKEIKFGNd-----------NFLDIIVSWFIRMRDIEEADLPKVEEykers---------------------qln 121  Debaryomyces han...
EAU91735   139 PSIAVIMSMWEVKkagee--vsgdpARMRLRVHWFLRPGELPAIRQKRDHVe---------------------------- 188  Coprinopsis cine...
Feature 1                                                                                      
1ZHI_A     135 kNELYLTAELAELQLFNFIRVANVMDGSKWevlkgn---------------vdperDFTVRYICEPTGe----KFVDINI 195  baker's yeast
2FL7_A     132 kSELYLTAELSEIWLKDFIAVGQILPESQWndssid---------------kiedrDFLVRYACEPTAe----KFVPIDI 192  baker's yeast
AAS52816   137 rSELYLTAELSEIYLKDLVSLAQVYDTDSFspecvt--------------qenqmtTFVVSSACEPDGn----NFVAINI 198  Ashbya gossypii ...
6093623    121 -NELLLTPFRSEVKFIDFIRPINVLSESQFadvvid--------------esnshsTFLVKRATDNEG-----NFSDIFD 180  Candida albicans
CAH02150   132 kNELYLTAELSEIYLRDLQFVANIKNEKEYldsvne--------------gkmdsnMFLCRSACLPSGt----NLADLDI 193  Kluyveromyces la...
CAG62232   135 dKELFFTATLIEIKLEQIIDKAKVLNQTEWnllstt--------------dkgyetTYFLRYACEPSSs----NFVAIDI 196  Candida glabrata...
XP_502645  101 gQELVMMNSIVDVLVEELHLPVNCYSFAEFealsre--------------dkkgdnVYFCRYVFDNDAnktsvEFDWQDI 166  Yarrowia lipolyt...
CAE76259   138 eNELYITPSFDFNALTTINGKAIVMSQEAFmkqyptgkv--------prkskefgkVFICRRGCNTRTctytdEFKWEDI 209  Neurospora crassa
EAS27777   158 pNEQYITVDFNVNPLTSINGKAKVLSKDAFyakypdgkppk-----grsalaeynkCIICRRGVNQLQgryteEFIWEDI 232  Coccidioides imm...
CAG62355   128 rDEIYLTAEITPIWLKDFIDIAEVYNAKKWaqvrqs---------------vnkerNFLVRYVCEPVAe----NFVPVDI 188  Candida glabrata...
CAG87030   122 eNELFITSYLDEVKLGEIIDKVNILSEEEFnndivid-------------dsnkasTFICRRGCDSAGe----LFTDVFD 184  Debaryomyces han...
EAU91735   189 -NEIYYSLHSTDILVPTVIVSRCSVSSHTAhiqktvkatgrsrgyqeiddsetgeqKFFCRFAINSQRgl-yyEWNWDDH 266  Coprinopsis cine...

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